New Multicomponent Bioerodible Electrospun Nanofibers for Dual-controlled Drug Release

The objective of this study was to evaluate the bioerodible polymer poly(maleic anhydride-alt-2-methoxyethyl vinyl ether) n-butyl hemiester, for multicomponent drug-loaded nanofibers produced by electrospinning. Diclofenac sodium (DS) and human serum albumin (HSA) were used as conventional drug and...

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Veröffentlicht in:Journal of bioactive and compatible polymers 2008-09, Vol.23 (5), p.423-443
Hauptverfasser: Piras, A.M., Chiellini, F., Chiellini, E., Nikkola, L., Ashammakhi, N.
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container_end_page 443
container_issue 5
container_start_page 423
container_title Journal of bioactive and compatible polymers
container_volume 23
creator Piras, A.M.
Chiellini, F.
Chiellini, E.
Nikkola, L.
Ashammakhi, N.
description The objective of this study was to evaluate the bioerodible polymer poly(maleic anhydride-alt-2-methoxyethyl vinyl ether) n-butyl hemiester, for multicomponent drug-loaded nanofibers produced by electrospinning. Diclofenac sodium (DS) and human serum albumin (HSA) were used as conventional drug and biopharmaceutical models. The influence of drug loading was correlated to beads presence, morphology and fibers diameter. When DS and HSA were loaded separately, a uniform distribution within fibers and beads was observed. However, when both components were loaded simultaneously, a heterogeneous distribution of DS was observed with a prominent amount in the cylindrical beads. The in vitro drug release evaluation from these nanomaterials displayed an independent delivery of the two components. These studies support the feasibility of multicomponent, bioerodible polymeric nanofibers preparation loaded with combination of traditional drugs and proteins.
doi_str_mv 10.1177/0883911508093357
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title New Multicomponent Bioerodible Electrospun Nanofibers for Dual-controlled Drug Release
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