Metallothioneins (MTs) and δ-aminolevulinic acid dehydratase (ALAd) as biomarkers of metal pollution in great tits ( Parus major) along a pollution gradient
Biomonitoring allows an integrated evaluation of different aspects of exposure, accumulation and effects to environmental pollution, simultaneously accounting for the natural variety between individuals in an ecosystem. In this study, the effects of increased metal accumulation were evaluated at the...
Gespeichert in:
| Veröffentlicht in: | The Science of the total environment 2008-08, Vol.401 (1), p.184-193 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 193 |
|---|---|
| container_issue | 1 |
| container_start_page | 184 |
| container_title | The Science of the total environment |
| container_volume | 401 |
| creator | Vanparys, Caroline Dauwe, Tom Van Campenhout, Karen Bervoets, Lieven De Coen, Wim Blust, Ronny Eens, Marcel |
| description | Biomonitoring allows an integrated evaluation of different aspects of exposure, accumulation and effects to environmental pollution, simultaneously accounting for the natural variety between individuals in an ecosystem. In this study, the effects of increased metal accumulation were evaluated at the biochemical level in terms of two biomarker responses in the great tit (
Parus major), a small insectivorous songbird, along an established metal pollution gradient. Metal concentrations in internal tissues (liver and kidney) and blood indicated that lead and cadmium were the most important metals in the pollution gradient under study. At the biochemical level, induction of metal binding protein metallothionein (MT) in liver and kidney reflected cadmium concentrations in these tissues (
R
2
=
0.42 and
R
2
=
0.94 respectively,
n
=
19), although in kidney, MT induction was not sufficient to complex all cadmium present. Secondly, the activity of the enzyme δ-aminolevulinic acid dehydratase (ALAd) in blood decreased exponentially in response to increased lead accumulation (
R
2
=
0.70,
n
=
18) and represents therefore a specific effect marker for lead exposure. In the highest polluted area, an ALAd inhibition of 85% was reported. Since a higher metal exposure resulted in an increased metal accumulation and subsequent biomarker responses in a dose-dependent way, this study indicates the applicability of ALAd and MT levels in great tits for biomonitoring responses to heavy metal pollution. |
| doi_str_mv | 10.1016/j.scitotenv.2008.04.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_33569864</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0048969708004166</els_id><sourcerecordid>33569864</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-225aea70f69b482b46dabaa83ed68bd1e433762daad28d7d71556d5ff2667f233</originalsourceid><addsrcrecordid>eNqFkcFu1DAURSMEokPhF6hXqCwy2I7jOMtRVSjSVCDRrq2X-GXqIbEH2xmpH8Nf8B18Uz2aEbDjbbw59973fIvigtElo0x-2C5jb5NP6PZLTqlaUrGktH1WLJhq2pJRLp8XC0qFKlvZNmfFqxi3NE-j2MvijCnRtrxii-LnLSYYR58erHdoXSSXt3fxPQFnyO9fJUzW-RH382id7Qn01hCDD48mQIKI5HK1XplMR9JZP0H4jiESP5Dp4Ep2fhznlI2JdWQTEBJJNuUI8hXCHMkEWx-yevRuQ-AffBPAWHTpdfFigDHim9N7Xtx_vL67uinXXz59vlqty15wkUrOa0Bo6CDbTijeCWmgA1AVGqk6w1BUVSO5ATBcmcY0rK6lqYeBS9kMvKrOi3dH313wP2aMSU829jiO4NDPUVdVLVslRQabI9gHH2PAQe-CzXc_akb1oRm91X-a0YdmNBU6N5OVb08Rczeh-as7VZGBiyMwgNewCTbq-2-csiqraSOUzMTqSGD-ir3FcIhC16OxAfukjbf_XeMJr9iweg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>33569864</pqid></control><display><type>article</type><title>Metallothioneins (MTs) and δ-aminolevulinic acid dehydratase (ALAd) as biomarkers of metal pollution in great tits ( Parus major) along a pollution gradient</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Vanparys, Caroline ; Dauwe, Tom ; Van Campenhout, Karen ; Bervoets, Lieven ; De Coen, Wim ; Blust, Ronny ; Eens, Marcel</creator><creatorcontrib>Vanparys, Caroline ; Dauwe, Tom ; Van Campenhout, Karen ; Bervoets, Lieven ; De Coen, Wim ; Blust, Ronny ; Eens, Marcel</creatorcontrib><description>Biomonitoring allows an integrated evaluation of different aspects of exposure, accumulation and effects to environmental pollution, simultaneously accounting for the natural variety between individuals in an ecosystem. In this study, the effects of increased metal accumulation were evaluated at the biochemical level in terms of two biomarker responses in the great tit (
Parus major), a small insectivorous songbird, along an established metal pollution gradient. Metal concentrations in internal tissues (liver and kidney) and blood indicated that lead and cadmium were the most important metals in the pollution gradient under study. At the biochemical level, induction of metal binding protein metallothionein (MT) in liver and kidney reflected cadmium concentrations in these tissues (
R
2
=
0.42 and
R
2
=
0.94 respectively,
n
=
19), although in kidney, MT induction was not sufficient to complex all cadmium present. Secondly, the activity of the enzyme δ-aminolevulinic acid dehydratase (ALAd) in blood decreased exponentially in response to increased lead accumulation (
R
2
=
0.70,
n
=
18) and represents therefore a specific effect marker for lead exposure. In the highest polluted area, an ALAd inhibition of 85% was reported. Since a higher metal exposure resulted in an increased metal accumulation and subsequent biomarker responses in a dose-dependent way, this study indicates the applicability of ALAd and MT levels in great tits for biomonitoring responses to heavy metal pollution.</description><identifier>ISSN: 0048-9697</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2008.04.009</identifier><identifier>PMID: 18499231</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Accounting ; aminolevulinic acid ; Animals ; Binding ; Biochemistry ; Biology ; biomarkers ; Biomarkers - analysis ; Biomonitoring ; Birds ; Blood ; Cadmium ; Cadmium - blood ; Cadmium - pharmacokinetics ; Concentration gradient ; Dehydration ; Dose-Response Relationship, Drug ; Ecosystems ; Environmental Monitoring ; Environmental Pollutants - blood ; Environmental Pollutants - pharmacokinetics ; Enzymes ; Geography ; Heavy metals ; indicator species ; Inhibition ; Kidney - drug effects ; Kidney - metabolism ; Kidneys ; Lead - blood ; Lead - pharmacokinetics ; Liver ; Liver - drug effects ; Liver - metabolism ; Markers ; Metallothionein ; Metallothionein - blood ; Metallothionein - pharmacology ; Metals, Heavy - blood ; Metals, Heavy - pharmacokinetics ; Parus major ; pollution ; Pollution abatement ; Porphobilinogen Synthase - antagonists & inhibitors ; Porphobilinogen Synthase - blood ; Porphobilinogen Synthase - pharmacokinetics ; Proteins ; Tissue Distribution ; Toxicology ; wild birds ; Zinc - blood ; Zinc - pharmacokinetics ; δ-Aminolevulinic acid dehydratase</subject><ispartof>The Science of the total environment, 2008-08, Vol.401 (1), p.184-193</ispartof><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-225aea70f69b482b46dabaa83ed68bd1e433762daad28d7d71556d5ff2667f233</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2008.04.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18499231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanparys, Caroline</creatorcontrib><creatorcontrib>Dauwe, Tom</creatorcontrib><creatorcontrib>Van Campenhout, Karen</creatorcontrib><creatorcontrib>Bervoets, Lieven</creatorcontrib><creatorcontrib>De Coen, Wim</creatorcontrib><creatorcontrib>Blust, Ronny</creatorcontrib><creatorcontrib>Eens, Marcel</creatorcontrib><title>Metallothioneins (MTs) and δ-aminolevulinic acid dehydratase (ALAd) as biomarkers of metal pollution in great tits ( Parus major) along a pollution gradient</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Biomonitoring allows an integrated evaluation of different aspects of exposure, accumulation and effects to environmental pollution, simultaneously accounting for the natural variety between individuals in an ecosystem. In this study, the effects of increased metal accumulation were evaluated at the biochemical level in terms of two biomarker responses in the great tit (
Parus major), a small insectivorous songbird, along an established metal pollution gradient. Metal concentrations in internal tissues (liver and kidney) and blood indicated that lead and cadmium were the most important metals in the pollution gradient under study. At the biochemical level, induction of metal binding protein metallothionein (MT) in liver and kidney reflected cadmium concentrations in these tissues (
R
2
=
0.42 and
R
2
=
0.94 respectively,
n
=
19), although in kidney, MT induction was not sufficient to complex all cadmium present. Secondly, the activity of the enzyme δ-aminolevulinic acid dehydratase (ALAd) in blood decreased exponentially in response to increased lead accumulation (
R
2
=
0.70,
n
=
18) and represents therefore a specific effect marker for lead exposure. In the highest polluted area, an ALAd inhibition of 85% was reported. Since a higher metal exposure resulted in an increased metal accumulation and subsequent biomarker responses in a dose-dependent way, this study indicates the applicability of ALAd and MT levels in great tits for biomonitoring responses to heavy metal pollution.</description><subject>Accounting</subject><subject>aminolevulinic acid</subject><subject>Animals</subject><subject>Binding</subject><subject>Biochemistry</subject><subject>Biology</subject><subject>biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Biomonitoring</subject><subject>Birds</subject><subject>Blood</subject><subject>Cadmium</subject><subject>Cadmium - blood</subject><subject>Cadmium - pharmacokinetics</subject><subject>Concentration gradient</subject><subject>Dehydration</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ecosystems</subject><subject>Environmental Monitoring</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - pharmacokinetics</subject><subject>Enzymes</subject><subject>Geography</subject><subject>Heavy metals</subject><subject>indicator species</subject><subject>Inhibition</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Lead - blood</subject><subject>Lead - pharmacokinetics</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Markers</subject><subject>Metallothionein</subject><subject>Metallothionein - blood</subject><subject>Metallothionein - pharmacology</subject><subject>Metals, Heavy - blood</subject><subject>Metals, Heavy - pharmacokinetics</subject><subject>Parus major</subject><subject>pollution</subject><subject>Pollution abatement</subject><subject>Porphobilinogen Synthase - antagonists & inhibitors</subject><subject>Porphobilinogen Synthase - blood</subject><subject>Porphobilinogen Synthase - pharmacokinetics</subject><subject>Proteins</subject><subject>Tissue Distribution</subject><subject>Toxicology</subject><subject>wild birds</subject><subject>Zinc - blood</subject><subject>Zinc - pharmacokinetics</subject><subject>δ-Aminolevulinic acid dehydratase</subject><issn>0048-9697</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAURSMEokPhF6hXqCwy2I7jOMtRVSjSVCDRrq2X-GXqIbEH2xmpH8Nf8B18Uz2aEbDjbbw59973fIvigtElo0x-2C5jb5NP6PZLTqlaUrGktH1WLJhq2pJRLp8XC0qFKlvZNmfFqxi3NE-j2MvijCnRtrxii-LnLSYYR58erHdoXSSXt3fxPQFnyO9fJUzW-RH382id7Qn01hCDD48mQIKI5HK1XplMR9JZP0H4jiESP5Dp4Ep2fhznlI2JdWQTEBJJNuUI8hXCHMkEWx-yevRuQ-AffBPAWHTpdfFigDHim9N7Xtx_vL67uinXXz59vlqty15wkUrOa0Bo6CDbTijeCWmgA1AVGqk6w1BUVSO5ATBcmcY0rK6lqYeBS9kMvKrOi3dH313wP2aMSU829jiO4NDPUVdVLVslRQabI9gHH2PAQe-CzXc_akb1oRm91X-a0YdmNBU6N5OVb08Rczeh-as7VZGBiyMwgNewCTbq-2-csiqraSOUzMTqSGD-ir3FcIhC16OxAfukjbf_XeMJr9iweg</recordid><startdate>20080815</startdate><enddate>20080815</enddate><creator>Vanparys, Caroline</creator><creator>Dauwe, Tom</creator><creator>Van Campenhout, Karen</creator><creator>Bervoets, Lieven</creator><creator>De Coen, Wim</creator><creator>Blust, Ronny</creator><creator>Eens, Marcel</creator><general>Elsevier B.V</general><general>[Amsterdam; New York]: Elsevier Science</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SU</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20080815</creationdate><title>Metallothioneins (MTs) and δ-aminolevulinic acid dehydratase (ALAd) as biomarkers of metal pollution in great tits ( Parus major) along a pollution gradient</title><author>Vanparys, Caroline ; Dauwe, Tom ; Van Campenhout, Karen ; Bervoets, Lieven ; De Coen, Wim ; Blust, Ronny ; Eens, Marcel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-225aea70f69b482b46dabaa83ed68bd1e433762daad28d7d71556d5ff2667f233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Accounting</topic><topic>aminolevulinic acid</topic><topic>Animals</topic><topic>Binding</topic><topic>Biochemistry</topic><topic>Biology</topic><topic>biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Biomonitoring</topic><topic>Birds</topic><topic>Blood</topic><topic>Cadmium</topic><topic>Cadmium - blood</topic><topic>Cadmium - pharmacokinetics</topic><topic>Concentration gradient</topic><topic>Dehydration</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ecosystems</topic><topic>Environmental Monitoring</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - pharmacokinetics</topic><topic>Enzymes</topic><topic>Geography</topic><topic>Heavy metals</topic><topic>indicator species</topic><topic>Inhibition</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>Lead - blood</topic><topic>Lead - pharmacokinetics</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Markers</topic><topic>Metallothionein</topic><topic>Metallothionein - blood</topic><topic>Metallothionein - pharmacology</topic><topic>Metals, Heavy - blood</topic><topic>Metals, Heavy - pharmacokinetics</topic><topic>Parus major</topic><topic>pollution</topic><topic>Pollution abatement</topic><topic>Porphobilinogen Synthase - antagonists & inhibitors</topic><topic>Porphobilinogen Synthase - blood</topic><topic>Porphobilinogen Synthase - pharmacokinetics</topic><topic>Proteins</topic><topic>Tissue Distribution</topic><topic>Toxicology</topic><topic>wild birds</topic><topic>Zinc - blood</topic><topic>Zinc - pharmacokinetics</topic><topic>δ-Aminolevulinic acid dehydratase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanparys, Caroline</creatorcontrib><creatorcontrib>Dauwe, Tom</creatorcontrib><creatorcontrib>Van Campenhout, Karen</creatorcontrib><creatorcontrib>Bervoets, Lieven</creatorcontrib><creatorcontrib>De Coen, Wim</creatorcontrib><creatorcontrib>Blust, Ronny</creatorcontrib><creatorcontrib>Eens, Marcel</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanparys, Caroline</au><au>Dauwe, Tom</au><au>Van Campenhout, Karen</au><au>Bervoets, Lieven</au><au>De Coen, Wim</au><au>Blust, Ronny</au><au>Eens, Marcel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metallothioneins (MTs) and δ-aminolevulinic acid dehydratase (ALAd) as biomarkers of metal pollution in great tits ( Parus major) along a pollution gradient</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2008-08-15</date><risdate>2008</risdate><volume>401</volume><issue>1</issue><spage>184</spage><epage>193</epage><pages>184-193</pages><issn>0048-9697</issn><eissn>1879-1026</eissn><abstract>Biomonitoring allows an integrated evaluation of different aspects of exposure, accumulation and effects to environmental pollution, simultaneously accounting for the natural variety between individuals in an ecosystem. In this study, the effects of increased metal accumulation were evaluated at the biochemical level in terms of two biomarker responses in the great tit (
Parus major), a small insectivorous songbird, along an established metal pollution gradient. Metal concentrations in internal tissues (liver and kidney) and blood indicated that lead and cadmium were the most important metals in the pollution gradient under study. At the biochemical level, induction of metal binding protein metallothionein (MT) in liver and kidney reflected cadmium concentrations in these tissues (
R
2
=
0.42 and
R
2
=
0.94 respectively,
n
=
19), although in kidney, MT induction was not sufficient to complex all cadmium present. Secondly, the activity of the enzyme δ-aminolevulinic acid dehydratase (ALAd) in blood decreased exponentially in response to increased lead accumulation (
R
2
=
0.70,
n
=
18) and represents therefore a specific effect marker for lead exposure. In the highest polluted area, an ALAd inhibition of 85% was reported. Since a higher metal exposure resulted in an increased metal accumulation and subsequent biomarker responses in a dose-dependent way, this study indicates the applicability of ALAd and MT levels in great tits for biomonitoring responses to heavy metal pollution.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>18499231</pmid><doi>10.1016/j.scitotenv.2008.04.009</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0048-9697 |
| ispartof | The Science of the total environment, 2008-08, Vol.401 (1), p.184-193 |
| issn | 0048-9697 1879-1026 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_33569864 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Accounting aminolevulinic acid Animals Binding Biochemistry Biology biomarkers Biomarkers - analysis Biomonitoring Birds Blood Cadmium Cadmium - blood Cadmium - pharmacokinetics Concentration gradient Dehydration Dose-Response Relationship, Drug Ecosystems Environmental Monitoring Environmental Pollutants - blood Environmental Pollutants - pharmacokinetics Enzymes Geography Heavy metals indicator species Inhibition Kidney - drug effects Kidney - metabolism Kidneys Lead - blood Lead - pharmacokinetics Liver Liver - drug effects Liver - metabolism Markers Metallothionein Metallothionein - blood Metallothionein - pharmacology Metals, Heavy - blood Metals, Heavy - pharmacokinetics Parus major pollution Pollution abatement Porphobilinogen Synthase - antagonists & inhibitors Porphobilinogen Synthase - blood Porphobilinogen Synthase - pharmacokinetics Proteins Tissue Distribution Toxicology wild birds Zinc - blood Zinc - pharmacokinetics δ-Aminolevulinic acid dehydratase |
| title | Metallothioneins (MTs) and δ-aminolevulinic acid dehydratase (ALAd) as biomarkers of metal pollution in great tits ( Parus major) along a pollution gradient |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T13%3A11%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metallothioneins%20(MTs)%20and%20%CE%B4-aminolevulinic%20acid%20dehydratase%20(ALAd)%20as%20biomarkers%20of%20metal%20pollution%20in%20great%20tits%20(%20Parus%20major)%20along%20a%20pollution%20gradient&rft.jtitle=The%20Science%20of%20the%20total%20environment&rft.au=Vanparys,%20Caroline&rft.date=2008-08-15&rft.volume=401&rft.issue=1&rft.spage=184&rft.epage=193&rft.pages=184-193&rft.issn=0048-9697&rft.eissn=1879-1026&rft_id=info:doi/10.1016/j.scitotenv.2008.04.009&rft_dat=%3Cproquest_cross%3E33569864%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=33569864&rft_id=info:pmid/18499231&rft_els_id=S0048969708004166&rfr_iscdi=true |