Development of photocrosslinked sialic acid containing polymers for use in Abeta toxicity attenuation

beta-Amyloid peptide (Abeta), the primary protein component in senile plaques associated with Alzheimer's disease (AD), has been implicated in neurotoxicity associated with AD. Previous studies have shown that the Abeta-neuronal membrane interaction plays a crucial role in Abeta toxicity. More...

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Veröffentlicht in:	Biomaterials 2008-08, Vol.29 (24-25), p.3408-3414
Hauptverfasser:	Cowan, Christopher B, Coté, Gerard L, Good, Theresa A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - toxicity Animals Cell Line, Tumor Cell Survival - drug effects Cross-Linking Reagents - chemistry Cross-Linking Reagents - radiation effects Molecular Structure N-Acetylneuraminic Acid - chemistry N-Acetylneuraminic Acid - radiation effects Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Oligosaccharides - pharmacology Polymers - chemical synthesis Polymers - chemistry Polymers - pharmacology Spectroscopy, Fourier Transform Infrared
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