The effect of intramural delivery of polymeric nanoparticles loaded with the antiproliferative 2-aminochromone U-86983 on neointimal hyperplasia development in balloon-injured porcine coronary arteries

Applying local drug delivery techniques in treating restenosis with antiproliferative agents may prove useful in enhancing drug efficacy while minimizing inherent systemic toxicity. Using direct intramural delivery of drug-loaded nanoparticles (U-86NP) composed of the biodegradable co-polymer polyla...

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Veröffentlicht in:	Advanced drug delivery reviews 1997-02, Vol.24 (1), p.87-108
Hauptverfasser:	Humphrey, William R., Erickson, Laurence A., Simmons, Carol A., Northrup, Jennifer L., Wishka, Donn G., Morris, Joel, Labhasetwar, Vinod, Song, Cunxian, Levy, Robert J., Shebuski, Ronald J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Local drug delivery Pig Polylactic-polyglycolic acid PTCA Restenosis
Online-Zugang:	Volltext
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