Polymeric micelles as carriers of diagnostic agents
This review deals with diagnostic applications of polymeric micelles composed of amphiphilic block-copolymers. In aqueous solutions these polymers spontaneously form particles with diameter 20–100 nm. A variety of diagnostic moieties can be incorporated covalently or non-covalently into the particul...
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| Veröffentlicht in: | Advanced drug delivery reviews 1999-04, Vol.37 (1), p.81-88 |
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| container_title | Advanced drug delivery reviews |
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| creator | Trubetskoy, Vladimir S. |
| description | This review deals with diagnostic applications of polymeric micelles composed of amphiphilic block-copolymers. In aqueous solutions these polymers spontaneously form particles with diameter 20–100 nm. A variety of diagnostic moieties can be incorporated covalently or non-covalently into the particulates with high loads. Resulting particles can be used as particulate agents for diagnostic imaging using three major imaging modalities: gamma-scintigraphy, magnetic resonance imaging and computed tomography. The use of polyethyleneoxide–diacyllipid micelles loaded with chelated
111In/Gd
3+ as well as iodine-containing amphiphilic copolymer in percutaneous lymphography and blood pool/liver imaging are discussed as specific examples. |
| doi_str_mv | 10.1016/S0169-409X(98)00100-8 |
| format | Article |
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111In/Gd
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111In/Gd
3+ as well as iodine-containing amphiphilic copolymer in percutaneous lymphography and blood pool/liver imaging are discussed as specific examples.</description><subject>Agents</subject><subject>Amphiphilic block copolymers</subject><subject>Block copolymers</subject><subject>Computerized tomography</subject><subject>Contrast agents</subject><subject>Controlled drug delivery</subject><subject>Diagnostic radiography</subject><subject>Drug carriers</subject><subject>Gamma radiography</subject><subject>Imaging</subject><subject>Magnetic resonance imaging</subject><subject>Micelles</subject><subject>Particulates</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqF0U1LwzAYB_AgipvTj6D0JPNQzXvTk8jwDQYKKngLafp0RNp1Jp2wb2-6DvGkl-Tye_KE_x-hU4IvCSby6iUeecpx_j7N1QXGBONU7aExURlNFc35Phr_kBE6CuEjIppJfIhGBCuWZVSNEXtu600D3tmkcRbqGkJiQmKN9w58SNoqKZ1ZLNvQRWIWsOzCMTqoTB3gZHdP0Nvd7evsIZ0_3T_Obuap5VR0aVZYBQVTUDFsKRMsp4ZxoLIQVYVBKiaJZDY3TBhBBQhSECoItiSjQkjBJuh8eHfl2881hE43LvR_NEto10Ezxgnn7H9ICcdM8R5O_4REiZxRqiSJVAzU-jYED5VeedcYv9EE674BvW1A9_HqXOltA1rFubPdinXRQPlraog8gusBQIzuK4asg3WwtFA6D7bTZev-WfENl1GTWQ</recordid><startdate>19990405</startdate><enddate>19990405</enddate><creator>Trubetskoy, Vladimir S.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>19990405</creationdate><title>Polymeric micelles as carriers of diagnostic agents</title><author>Trubetskoy, Vladimir S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-7bc8eb38ef30c235392a34e26b5ff0e6836163c9a35a525e51b12510c17255653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Agents</topic><topic>Amphiphilic block copolymers</topic><topic>Block copolymers</topic><topic>Computerized tomography</topic><topic>Contrast agents</topic><topic>Controlled drug delivery</topic><topic>Diagnostic radiography</topic><topic>Drug carriers</topic><topic>Gamma radiography</topic><topic>Imaging</topic><topic>Magnetic resonance imaging</topic><topic>Micelles</topic><topic>Particulates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trubetskoy, Vladimir S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trubetskoy, Vladimir S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymeric micelles as carriers of diagnostic agents</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>1999-04-05</date><risdate>1999</risdate><volume>37</volume><issue>1</issue><spage>81</spage><epage>88</epage><pages>81-88</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>This review deals with diagnostic applications of polymeric micelles composed of amphiphilic block-copolymers. In aqueous solutions these polymers spontaneously form particles with diameter 20–100 nm. A variety of diagnostic moieties can be incorporated covalently or non-covalently into the particulates with high loads. Resulting particles can be used as particulate agents for diagnostic imaging using three major imaging modalities: gamma-scintigraphy, magnetic resonance imaging and computed tomography. The use of polyethyleneoxide–diacyllipid micelles loaded with chelated
111In/Gd
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| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 1999-04, Vol.37 (1), p.81-88 |
| issn | 0169-409X 1872-8294 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_33414435 |
| source | Elsevier ScienceDirect Journals |
| subjects | Agents Amphiphilic block copolymers Block copolymers Computerized tomography Contrast agents Controlled drug delivery Diagnostic radiography Drug carriers Gamma radiography Imaging Magnetic resonance imaging Micelles Particulates |
| title | Polymeric micelles as carriers of diagnostic agents |
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