Antithrombogenicity of Hydromer's polymeric formula F202TM immobilized on polyurethane and electropolished stainless steel
Hydromer's heparin‐polymer complex (F202™) was applied to polyurethane film and electropolished medical grade stainless steel. The presence of heparin on the surface was confirmed by FT‐IR and immunofluorescent histochemistry. The F202™ polymer was nonthrombogenic and the development of thrombi...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2008-07, Vol.86B (1), p.136-144 |
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| container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
| container_volume | 86B |
| creator | Vicario, Pasquale P. Lu, Zichun Wang, Zheng Merritt, Karen Buongiovanni, David Chen, Paul |
| description | Hydromer's heparin‐polymer complex (F202™) was applied to polyurethane film and electropolished medical grade stainless steel. The presence of heparin on the surface was confirmed by FT‐IR and immunofluorescent histochemistry. The F202™ polymer was nonthrombogenic and the development of thrombi on these surfaces after exposure to recalcified human whole blood was minimal or absent. Platelet adhesion to these F202™‐coated surfaces, compared to control (uncoated) surfaces, was low or absent after exposure to platelet‐rich plasma as determined by fluorescent staining and by immunohistochemistry. Our F202™ polymer was not hemolytic after exposure to human erythrocytes and was not cytotoxic in a standard cytotoxic protocol. The F202™ polymer could prove useful as an antithrombogenic coating for preventing thrombus formation on medical implants and catheters. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008 |
| doi_str_mv | 10.1002/jbm.b.30998 |
| format | Article |
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The presence of heparin on the surface was confirmed by FT‐IR and immunofluorescent histochemistry. The F202™ polymer was nonthrombogenic and the development of thrombi on these surfaces after exposure to recalcified human whole blood was minimal or absent. Platelet adhesion to these F202™‐coated surfaces, compared to control (uncoated) surfaces, was low or absent after exposure to platelet‐rich plasma as determined by fluorescent staining and by immunohistochemistry. Our F202™ polymer was not hemolytic after exposure to human erythrocytes and was not cytotoxic in a standard cytotoxic protocol. The F202™ polymer could prove useful as an antithrombogenic coating for preventing thrombus formation on medical implants and catheters. © 2007 Wiley Periodicals, Inc. 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J Biomed Mater Res Part B: Appl Biomater, 2008</description><subject>bioactivity/biocompatibility</subject><subject>coagulation</subject><subject>heparin</subject><subject>platelet adhesion</subject><subject>thrombogenicity</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOwzAQRSMEEs8VP-AVrFLsOIntZUG0gApsQLCz7GRCXZy42IkgfD2mRazmanTuPG6SnBI8IRhnFyvdTvSEYiH4TnJAiiJLc8HJ7r9mdD85DGEV4RIX9CD5nna96Zfetdq9QWcq04_INehmrGMP_HlAa2fHqEyFGufbwSo0y3D2dI9M2zptrPmGGrluww0e-qXqAKmuRmCh6r2LfROWkQm9Mp2FEKICsMfJXqNsgJO_epQ8z66frm7SxeP89mq6SA0hhKdxlyi0YCVmNMubilSK1lg1qqxExhnnmGWFEE3ZKJ4D8ILRshGVqgXXtYaSHiVn27lr7z4GCL1sTajA2ninG4KklArM2S9ItuCnsTDKtTet8qMkWP6GK2O4UstNuPLu8n4joifdekz86evfo_y7LBllhXx5mMsZyxeU4FeZ0x9K8YDz</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Vicario, Pasquale P.</creator><creator>Lu, Zichun</creator><creator>Wang, Zheng</creator><creator>Merritt, Karen</creator><creator>Buongiovanni, David</creator><creator>Chen, Paul</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>200807</creationdate><title>Antithrombogenicity of Hydromer's polymeric formula F202TM immobilized on polyurethane and electropolished stainless steel</title><author>Vicario, Pasquale P. ; Lu, Zichun ; Wang, Zheng ; Merritt, Karen ; Buongiovanni, David ; Chen, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1118-20295b97607324fc1ca3d0afa6c928788072599f6fa84ee85736f9cad98bdbe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>bioactivity/biocompatibility</topic><topic>coagulation</topic><topic>heparin</topic><topic>platelet adhesion</topic><topic>thrombogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vicario, Pasquale P.</creatorcontrib><creatorcontrib>Lu, Zichun</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Merritt, Karen</creatorcontrib><creatorcontrib>Buongiovanni, David</creatorcontrib><creatorcontrib>Chen, Paul</creatorcontrib><collection>Istex</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of biomedical materials research. 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The presence of heparin on the surface was confirmed by FT‐IR and immunofluorescent histochemistry. The F202™ polymer was nonthrombogenic and the development of thrombi on these surfaces after exposure to recalcified human whole blood was minimal or absent. Platelet adhesion to these F202™‐coated surfaces, compared to control (uncoated) surfaces, was low or absent after exposure to platelet‐rich plasma as determined by fluorescent staining and by immunohistochemistry. Our F202™ polymer was not hemolytic after exposure to human erythrocytes and was not cytotoxic in a standard cytotoxic protocol. The F202™ polymer could prove useful as an antithrombogenic coating for preventing thrombus formation on medical implants and catheters. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/jbm.b.30998</doi><tpages>9</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | bioactivity/biocompatibility coagulation heparin platelet adhesion thrombogenicity |
| title | Antithrombogenicity of Hydromer's polymeric formula F202TM immobilized on polyurethane and electropolished stainless steel |
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