Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies

Clinical development of orally active peptide drugs has been restricted by their unfavorable physicochemical properties, which limit their intestinal mucosal permeation and their lack of stability against enzymatic degradation. Successful oral delivery of peptides will depend, therefore, on strategi...

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Veröffentlicht in:	Advanced drug delivery reviews 1997-09, Vol.27 (2), p.235-256
Hauptverfasser:	Pauletti, Giovanni M., Gangwar, Sanjeev, Siahaan, Teruna J., Jeffrey Aubé, T. Borchardt, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Active and passive transport mechanisms Cells Efflux systems Enzyme inhibition Intestinal barrier properties Metabolism Oral peptide delivery Peptidomimetics Pharmacokinetics Prodrugs Substrates
Online-Zugang:	Volltext
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