Caco-2 monolayers in experimental and theoretical predictions of drug transport

This review examines the use of Caco-2 monolayers in the prediction of intestinal drug absorption. First, the different routes of drug transport in Caco-2 monolayers are compared with those seen in vivo. Second, the prediction of drug absorption in vivo from transport experiments in cell monolayers...

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Veröffentlicht in:	Advanced drug delivery reviews 1996-11, Vol.22 (1), p.67-84
Hauptverfasser:	Artursson, Per, Palm, Katrin, Luthman, Kristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Cell monolayer Desolvation energy Drug absorption Drug transport Hydrogen bonding potential In vitro-in vivo correlation Intestinal epithelium Molecular surface area Partition coefficient
Online-Zugang:	Volltext
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