Pegaspargase: a review of clinical studies

The chemotherapy agent l-asparaginase has been an important part of acute lymphoblastic leukemia therapy for over 30 years. Two of the main disadvantages of the drug are (1) the need for frequent intramuscular injection and (2) a very high rate of allergic reactions. Because of this, l-asparaginase...

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Veröffentlicht in:	Advanced drug delivery reviews 2003-09, Vol.55 (10), p.1293-1302
1. Verfasser:	Graham, Michael L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Antineoplastic agents Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Asparaginase Asparaginase - adverse effects Asparaginase - pharmacokinetics Asparaginase - therapeutic use Asparagine Bacterial proteins Chemical and Drug Induced Liver Injury - etiology Clinical Trials as Topic Drug Hypersensitivity - etiology Half-Life Humans Polyethylene glycols Polyethylene Glycols - adverse effects Polyethylene Glycols - pharmacokinetics Polyethylene Glycols - therapeutic use Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Remission induction
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