Antifolates targeted specifically to the folate receptor

Most antifolate drugs are efficiently transported by the reduced-folate carrier (RFC). However, several also bind with high affinity to the α-isoform of the folate receptor (α-FR) and there is evidence to suggest that this transport mechanism may contribute to their activity when the receptor is hig...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Advanced drug delivery reviews 2004-04, Vol.56 (8), p.1111-1125
Hauptverfasser:	Jackman, Ann L, Theti, Davinder S, Gibbs, David D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifolate Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Drug Delivery Systems - methods Folate Receptors, GPI-Anchored Folic Acid - metabolism Folic Acid Antagonists - administration & dosage Folic Acid Antagonists - chemistry Folic Acid Antagonists - metabolism Humans Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - metabolism Thymidylate synthase α-Folate receptor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!