Estrogenic effects of polychlorinated biphenyls and relation to cytochrome P4501A activity in the endangered Goodeid fish Ameca splendens
The present study examines the relationships between cytochrome P4501A (CYP1A) activity and vitellogenin (VTG) induction in Ameca splendens elicited by a polychlorinated biphenyl (PCB) mixture. Ethoxyresorufin‐O‐deethylase (EROD) activity, mRNA levels of VTG, and VTG induction were evaluated in male...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2008-04, Vol.27 (4), p.963-969 |
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| creator | Vega-Lopez, A Jimenez-Orozco, F.A Ramon-Gallegos, E Garcia-Latorre, E Dominguez-Lopez, M.L |
| description | The present study examines the relationships between cytochrome P4501A (CYP1A) activity and vitellogenin (VTG) induction in Ameca splendens elicited by a polychlorinated biphenyl (PCB) mixture. Ethoxyresorufin‐O‐deethylase (EROD) activity, mRNA levels of VTG, and VTG induction were evaluated in male and female fish exposed for 1, 2, 4, 8, and 16 d to a commercial PCB mixture. Polychlorinated biphenyls induced higher EROD in both sexes and this induction was higher in females than in males. Maximum EROD and VTG induction occurred on day 1 in females, while in males these maxima occurred on days 8 and 16. A correlation between EROD and VTG induction was found only in males (p < 0.001), and VTG induction was also higher in males than in females (p < 0.01). Exposure to PCBs elicited increases in VTG expression and induction over time in males, while in females these decreased at the end of the exposure period. Deficiencies in the feedback mechanisms of male A. splendens exposed in the wild to xenoestrogens such as PCBs have probably contributed to alter the sex ratio of wild populations of this species. |
| doi_str_mv | 10.1897/07-446.1 |
| format | Article |
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Ethoxyresorufin‐O‐deethylase (EROD) activity, mRNA levels of VTG, and VTG induction were evaluated in male and female fish exposed for 1, 2, 4, 8, and 16 d to a commercial PCB mixture. Polychlorinated biphenyls induced higher EROD in both sexes and this induction was higher in females than in males. Maximum EROD and VTG induction occurred on day 1 in females, while in males these maxima occurred on days 8 and 16. A correlation between EROD and VTG induction was found only in males (p < 0.001), and VTG induction was also higher in males than in females (p < 0.01). Exposure to PCBs elicited increases in VTG expression and induction over time in males, while in females these decreased at the end of the exposure period. Deficiencies in the feedback mechanisms of male A. splendens exposed in the wild to xenoestrogens such as PCBs have probably contributed to alter the sex ratio of wild populations of this species.</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1897/07-446.1</identifier><identifier>PMID: 18333695</identifier><language>eng</language><publisher>Hoboken: Wiley Periodicals, Inc</publisher><subject>Agricultural chemicals ; Ameca splendens ; Animals ; Bioaccumulation ; Cod ; Cyprinodontiformes ; Cytochrome ; cytochrome P-450 ; Cytochrome P-450 CYP1A1 - metabolism ; Cytochrome P450 ; endangered species ; environmental exposure ; Environmental monitoring ; enzyme activity ; estrogenic properties ; Estrogens - toxicity ; Females ; Fish ; Fishes ; Gene expression ; Hepatology ; Liver - enzymology ; Males ; messenger RNA ; Native species ; PCB ; Pituitary gland ; Polychlorinated biphenyls ; Polychlorinated Biphenyls - toxicity ; Risk factors ; Sex ratio ; Sex-linked differences ; Sexes ; sublethal effects ; toxicity ; Vitellogenin ; Vitellogenins - biosynthesis ; Water Pollutants, Chemical - toxicity ; water pollution ; Xenoestrogens</subject><ispartof>Environmental toxicology and chemistry, 2008-04, Vol.27 (4), p.963-969</ispartof><rights>Copyright © 2008 SETAC</rights><rights>Copyright Alliance Communications Group, A Division of Allen Press, Inc. Apr 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5423-7500b6968fb2eb177b0365db31bea3db8030151f483d2768b0a03388c463165f3</citedby><cites>FETCH-LOGICAL-c5423-7500b6968fb2eb177b0365db31bea3db8030151f483d2768b0a03388c463165f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1897%2F07-446.1$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1897%2F07-446.1$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18333695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vega-Lopez, A</creatorcontrib><creatorcontrib>Jimenez-Orozco, F.A</creatorcontrib><creatorcontrib>Ramon-Gallegos, E</creatorcontrib><creatorcontrib>Garcia-Latorre, E</creatorcontrib><creatorcontrib>Dominguez-Lopez, M.L</creatorcontrib><title>Estrogenic effects of polychlorinated biphenyls and relation to cytochrome P4501A activity in the endangered Goodeid fish Ameca splendens</title><title>Environmental toxicology and chemistry</title><addtitle>Environmental Toxicology and Chemistry</addtitle><description>The present study examines the relationships between cytochrome P4501A (CYP1A) activity and vitellogenin (VTG) induction in Ameca splendens elicited by a polychlorinated biphenyl (PCB) mixture. Ethoxyresorufin‐O‐deethylase (EROD) activity, mRNA levels of VTG, and VTG induction were evaluated in male and female fish exposed for 1, 2, 4, 8, and 16 d to a commercial PCB mixture. Polychlorinated biphenyls induced higher EROD in both sexes and this induction was higher in females than in males. Maximum EROD and VTG induction occurred on day 1 in females, while in males these maxima occurred on days 8 and 16. A correlation between EROD and VTG induction was found only in males (p < 0.001), and VTG induction was also higher in males than in females (p < 0.01). Exposure to PCBs elicited increases in VTG expression and induction over time in males, while in females these decreased at the end of the exposure period. Deficiencies in the feedback mechanisms of male A. splendens exposed in the wild to xenoestrogens such as PCBs have probably contributed to alter the sex ratio of wild populations of this species.</description><subject>Agricultural chemicals</subject><subject>Ameca splendens</subject><subject>Animals</subject><subject>Bioaccumulation</subject><subject>Cod</subject><subject>Cyprinodontiformes</subject><subject>Cytochrome</subject><subject>cytochrome P-450</subject><subject>Cytochrome P-450 CYP1A1 - metabolism</subject><subject>Cytochrome P450</subject><subject>endangered species</subject><subject>environmental exposure</subject><subject>Environmental monitoring</subject><subject>enzyme activity</subject><subject>estrogenic properties</subject><subject>Estrogens - toxicity</subject><subject>Females</subject><subject>Fish</subject><subject>Fishes</subject><subject>Gene expression</subject><subject>Hepatology</subject><subject>Liver - enzymology</subject><subject>Males</subject><subject>messenger RNA</subject><subject>Native species</subject><subject>PCB</subject><subject>Pituitary gland</subject><subject>Polychlorinated biphenyls</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Risk factors</subject><subject>Sex ratio</subject><subject>Sex-linked differences</subject><subject>Sexes</subject><subject>sublethal effects</subject><subject>toxicity</subject><subject>Vitellogenin</subject><subject>Vitellogenins - biosynthesis</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>water 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A</creator><creator>Jimenez-Orozco, F.A</creator><creator>Ramon-Gallegos, E</creator><creator>Garcia-Latorre, E</creator><creator>Dominguez-Lopez, M.L</creator><general>Wiley Periodicals, Inc</general><general>Blackwell Publishing 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effects of polychlorinated biphenyls and relation to cytochrome P4501A activity in the endangered Goodeid fish Ameca splendens</title><author>Vega-Lopez, A ; Jimenez-Orozco, F.A ; Ramon-Gallegos, E ; Garcia-Latorre, E ; Dominguez-Lopez, M.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5423-7500b6968fb2eb177b0365db31bea3db8030151f483d2768b0a03388c463165f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Agricultural chemicals</topic><topic>Ameca splendens</topic><topic>Animals</topic><topic>Bioaccumulation</topic><topic>Cod</topic><topic>Cyprinodontiformes</topic><topic>Cytochrome</topic><topic>cytochrome P-450</topic><topic>Cytochrome P-450 CYP1A1 - metabolism</topic><topic>Cytochrome P450</topic><topic>endangered species</topic><topic>environmental exposure</topic><topic>Environmental monitoring</topic><topic>enzyme activity</topic><topic>estrogenic 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chemistry</jtitle><addtitle>Environmental Toxicology and Chemistry</addtitle><date>2008-04</date><risdate>2008</risdate><volume>27</volume><issue>4</issue><spage>963</spage><epage>969</epage><pages>963-969</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><abstract>The present study examines the relationships between cytochrome P4501A (CYP1A) activity and vitellogenin (VTG) induction in Ameca splendens elicited by a polychlorinated biphenyl (PCB) mixture. Ethoxyresorufin‐O‐deethylase (EROD) activity, mRNA levels of VTG, and VTG induction were evaluated in male and female fish exposed for 1, 2, 4, 8, and 16 d to a commercial PCB mixture. Polychlorinated biphenyls induced higher EROD in both sexes and this induction was higher in females than in males. Maximum EROD and VTG induction occurred on day 1 in females, while in males these maxima occurred on days 8 and 16. A correlation between EROD and VTG induction was found only in males (p < 0.001), and VTG induction was also higher in males than in females (p < 0.01). Exposure to PCBs elicited increases in VTG expression and induction over time in males, while in females these decreased at the end of the exposure period. Deficiencies in the feedback mechanisms of male A. splendens exposed in the wild to xenoestrogens such as PCBs have probably contributed to alter the sex ratio of wild populations of this species.</abstract><cop>Hoboken</cop><pub>Wiley Periodicals, Inc</pub><pmid>18333695</pmid><doi>10.1897/07-446.1</doi><tpages>7</tpages></addata></record> |
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| ispartof | Environmental toxicology and chemistry, 2008-04, Vol.27 (4), p.963-969 |
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| subjects | Agricultural chemicals Ameca splendens Animals Bioaccumulation Cod Cyprinodontiformes Cytochrome cytochrome P-450 Cytochrome P-450 CYP1A1 - metabolism Cytochrome P450 endangered species environmental exposure Environmental monitoring enzyme activity estrogenic properties Estrogens - toxicity Females Fish Fishes Gene expression Hepatology Liver - enzymology Males messenger RNA Native species PCB Pituitary gland Polychlorinated biphenyls Polychlorinated Biphenyls - toxicity Risk factors Sex ratio Sex-linked differences Sexes sublethal effects toxicity Vitellogenin Vitellogenins - biosynthesis Water Pollutants, Chemical - toxicity water pollution Xenoestrogens |
| title | Estrogenic effects of polychlorinated biphenyls and relation to cytochrome P4501A activity in the endangered Goodeid fish Ameca splendens |
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