Controlled release of bovine serum albumin from hydroxyapatite microspheres for protein delivery system
Desorption behavior of a model protein (bovine serum albumin, BSA) on commercial hydroxyapatite (HAp) microspheres and its control were investigated for protein delivery system. The desorption behavior related strongly to the phosphate concentration in phosphate buffer solution: the amount of desorb...
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| Veröffentlicht in: | Materials science & engineering. B, Solid-state materials for advanced technology Solid-state materials for advanced technology, 2008-02, Vol.148 (1), p.162-165 |
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| container_title | Materials science & engineering. B, Solid-state materials for advanced technology |
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| creator | Boonsongrit, Yaowalak Abe, Hiroya Sato, Kazuyoshi Naito, Makio Yoshimura, Masahiro Ichikawa, Hideki Fukumori, Yoshinobu |
| description | Desorption behavior of a model protein (bovine serum albumin, BSA) on commercial hydroxyapatite (HAp) microspheres and its control were investigated for protein delivery system. The desorption behavior related strongly to the phosphate concentration in phosphate buffer solution: the amount of desorbed BSA increased when the phosphate concentration increased. In physiological buffer solution, which contains 10
mM phosphate, the initial burst release of BSA was observed: 70% of BSA was rapidly desorbed after 0.5
h, and 80% after 24
h. In contrast, the extremely low release profile of BSA was observed in distilled water. For the controlled release of BSA in physiological condition, the BSA-loaded HAp microspheres were encapsulated with a biodegradable polymer, poly(lactic acid-
co-glycolic acid) (PLGA) by a solid-in oil-in water (S/O/W) emulsion solvent evaporation method. The initial burst was significantly reduced, and the BSA release was remarkably prolonged by the encapsulation. |
| doi_str_mv | 10.1016/j.mseb.2007.09.006 |
| format | Article |
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mM phosphate, the initial burst release of BSA was observed: 70% of BSA was rapidly desorbed after 0.5
h, and 80% after 24
h. In contrast, the extremely low release profile of BSA was observed in distilled water. For the controlled release of BSA in physiological condition, the BSA-loaded HAp microspheres were encapsulated with a biodegradable polymer, poly(lactic acid-
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mM phosphate, the initial burst release of BSA was observed: 70% of BSA was rapidly desorbed after 0.5
h, and 80% after 24
h. In contrast, the extremely low release profile of BSA was observed in distilled water. For the controlled release of BSA in physiological condition, the BSA-loaded HAp microspheres were encapsulated with a biodegradable polymer, poly(lactic acid-
co-glycolic acid) (PLGA) by a solid-in oil-in water (S/O/W) emulsion solvent evaporation method. The initial burst was significantly reduced, and the BSA release was remarkably prolonged by the encapsulation.</description><subject>Biodegradable polymer</subject><subject>Carboxylic acid</subject><subject>Drug delivery system</subject><subject>Hydroxyapatite</subject><subject>Protein</subject><issn>0921-5107</issn><issn>1873-4944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAURS0EEqXwB5g8sSU8O6kdSyyo4kuqxAKz5STP1FUSFzupyL8nocwwveWcq3cvIdcMUgZM3O7SNmKZcgCZgkoBxAlZsEJmSa7y_JQsQHGWrBjIc3IR4w4AGOd8QT7WvuuDbxqsacAGTUTqLS39wXVII4ahpaYph9Z11Abf0u1YB_81mr3pXY-0dVXwcb_FgJFaH-g--B4nuMbGHTCMNI6xx_aSnFnTRLz6vUvy_vjwtn5ONq9PL-v7TVLlkvdJKaTlvM4EK1nNBRaiLIBJqbI8t5lQwq6EqjJhxSqTjDElJPIJngSDzGK2JDfH3OmPzwFjr1sXK2wa06Efos44l_mc9x_IoYBCgJhAfgTnojGg1fvgWhNGzUDP4-udnsfX8_galIYf6e4o4dT14DDoWDnsKqxdwKrXtXd_6d9fmY7s</recordid><startdate>20080225</startdate><enddate>20080225</enddate><creator>Boonsongrit, Yaowalak</creator><creator>Abe, Hiroya</creator><creator>Sato, Kazuyoshi</creator><creator>Naito, Makio</creator><creator>Yoshimura, Masahiro</creator><creator>Ichikawa, Hideki</creator><creator>Fukumori, Yoshinobu</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>8BQ</scope><scope>JG9</scope></search><sort><creationdate>20080225</creationdate><title>Controlled release of bovine serum albumin from hydroxyapatite microspheres for protein delivery system</title><author>Boonsongrit, Yaowalak ; Abe, Hiroya ; Sato, Kazuyoshi ; Naito, Makio ; Yoshimura, Masahiro ; Ichikawa, Hideki ; Fukumori, Yoshinobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-b67f22d361b1d26e86b801779344f3696f569c36f6537111967e261b361ae1fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biodegradable polymer</topic><topic>Carboxylic acid</topic><topic>Drug delivery system</topic><topic>Hydroxyapatite</topic><topic>Protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boonsongrit, Yaowalak</creatorcontrib><creatorcontrib>Abe, Hiroya</creatorcontrib><creatorcontrib>Sato, Kazuyoshi</creatorcontrib><creatorcontrib>Naito, Makio</creatorcontrib><creatorcontrib>Yoshimura, Masahiro</creatorcontrib><creatorcontrib>Ichikawa, Hideki</creatorcontrib><creatorcontrib>Fukumori, Yoshinobu</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><jtitle>Materials science & engineering. B, Solid-state materials for advanced technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boonsongrit, Yaowalak</au><au>Abe, Hiroya</au><au>Sato, Kazuyoshi</au><au>Naito, Makio</au><au>Yoshimura, Masahiro</au><au>Ichikawa, Hideki</au><au>Fukumori, Yoshinobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled release of bovine serum albumin from hydroxyapatite microspheres for protein delivery system</atitle><jtitle>Materials science & engineering. B, Solid-state materials for advanced technology</jtitle><date>2008-02-25</date><risdate>2008</risdate><volume>148</volume><issue>1</issue><spage>162</spage><epage>165</epage><pages>162-165</pages><issn>0921-5107</issn><eissn>1873-4944</eissn><abstract>Desorption behavior of a model protein (bovine serum albumin, BSA) on commercial hydroxyapatite (HAp) microspheres and its control were investigated for protein delivery system. The desorption behavior related strongly to the phosphate concentration in phosphate buffer solution: the amount of desorbed BSA increased when the phosphate concentration increased. In physiological buffer solution, which contains 10
mM phosphate, the initial burst release of BSA was observed: 70% of BSA was rapidly desorbed after 0.5
h, and 80% after 24
h. In contrast, the extremely low release profile of BSA was observed in distilled water. For the controlled release of BSA in physiological condition, the BSA-loaded HAp microspheres were encapsulated with a biodegradable polymer, poly(lactic acid-
co-glycolic acid) (PLGA) by a solid-in oil-in water (S/O/W) emulsion solvent evaporation method. The initial burst was significantly reduced, and the BSA release was remarkably prolonged by the encapsulation.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.mseb.2007.09.006</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0921-5107 |
| ispartof | Materials science & engineering. B, Solid-state materials for advanced technology, 2008-02, Vol.148 (1), p.162-165 |
| issn | 0921-5107 1873-4944 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_32274779 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Biodegradable polymer Carboxylic acid Drug delivery system Hydroxyapatite Protein |
| title | Controlled release of bovine serum albumin from hydroxyapatite microspheres for protein delivery system |
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