Bridging biomolecules with nanoparticles: surface-enhanced Raman scattering from colon carcinoma and normal tissue
In order to get insight into the chemical heterogeneities of solid tumors, here we report the first surface‐enhanced Raman scattering (SERS) experiment from normal and altered epithelial layer in human colon carcinoma tissues. The Ag colloidal nanoparticles that can be incorporated into the intersti...
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| Veröffentlicht in: | Journal of Raman spectroscopy 2008-03, Vol.39 (3), p.331-334 |
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| creator | Pînzaru, S. Cîntă Andronie, L. M. Domsa, I. Cozar, O. Astilean, S. |
| description | In order to get insight into the chemical heterogeneities of solid tumors, here we report the first surface‐enhanced Raman scattering (SERS) experiment from normal and altered epithelial layer in human colon carcinoma tissues. The Ag colloidal nanoparticles that can be incorporated into the interstitial space in solid tumors or those penetrating into cytoplasm or nucleus of many cells allowed high quality SERS signal. Different tissue structures of tumor and normal colon have characteristic features in SERS spectra. Prominent SERS features of malignant tissue spectra are related to the strong enhancement of the bands preponderantly attributable to DNA or RNA bases. The preliminary studies demonstrate that it is possible to probe Ag colloidal nanoparticles adsorption onto the tissue resulting in a strong molecular signaling with high specificity and rapid acquisition time using visible laser line excitation. Copyright © 2008 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/jrs.1907 |
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Cîntă ; Andronie, L. M. ; Domsa, I. ; Cozar, O. ; Astilean, S.</creator><creatorcontrib>Pînzaru, S. Cîntă ; Andronie, L. M. ; Domsa, I. ; Cozar, O. ; Astilean, S.</creatorcontrib><description>In order to get insight into the chemical heterogeneities of solid tumors, here we report the first surface‐enhanced Raman scattering (SERS) experiment from normal and altered epithelial layer in human colon carcinoma tissues. The Ag colloidal nanoparticles that can be incorporated into the interstitial space in solid tumors or those penetrating into cytoplasm or nucleus of many cells allowed high quality SERS signal. Different tissue structures of tumor and normal colon have characteristic features in SERS spectra. Prominent SERS features of malignant tissue spectra are related to the strong enhancement of the bands preponderantly attributable to DNA or RNA bases. The preliminary studies demonstrate that it is possible to probe Ag colloidal nanoparticles adsorption onto the tissue resulting in a strong molecular signaling with high specificity and rapid acquisition time using visible laser line excitation. 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Prominent SERS features of malignant tissue spectra are related to the strong enhancement of the bands preponderantly attributable to DNA or RNA bases. The preliminary studies demonstrate that it is possible to probe Ag colloidal nanoparticles adsorption onto the tissue resulting in a strong molecular signaling with high specificity and rapid acquisition time using visible laser line excitation. Copyright © 2008 John Wiley & Sons, Ltd.</description><subject>adenocarcinoma</subject><subject>Ag nanoparticles</subject><subject>Colloids</subject><subject>Colon</subject><subject>colon tissues</subject><subject>Heterogeneity</subject><subject>micro-Raman</subject><subject>Nanoparticles</subject><subject>Raman scattering</subject><subject>SERS</subject><subject>Silver</subject><subject>Spectra</subject><subject>Tumors</subject><issn>0377-0486</issn><issn>1097-4555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp90E1LHjEUBeBQFPr6Af0JWZVuRpNJJpl0V8XPiqXa0u7CnTsZjc4kr8kM6r93XiwWF7q6cHk4HA4hnzjb4YyVuzcp73DD9Aey4MzoQlZVtUYWTGhdMFmrj2Qj5xvGmDGKL0jaS7698uGKNj4OsXc49S7Tez9e0wAhLiGNHufXV5qn1AG6woVrCOhaegEDBJoRxtGlVUSX4kAx9jFQhIQ-xAEohJaGmAbo6ehzntwWWe-gz277390kvw8Pfu0fF2c_jk72v50VKNRc1nClTYOsBs7a1iijuZJdaeqy66RuGtc6bhqDpeaAsjNQY4kSldCmZoKj2CSfn3OXKd5NLo928Bld30NwccpWlKXURqoZfnkXzkW45ExU_D_FFHNOrrPL5AdIj5Yzu9rfzvvb1f4zLZ7pve_d45vOnl5cvvY-j-7hxUO6tUoLXdk_50f27576_lMfnlstngBqz5ef</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Pînzaru, S. 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| ispartof | Journal of Raman spectroscopy, 2008-03, Vol.39 (3), p.331-334 |
| issn | 0377-0486 1097-4555 |
| language | eng |
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| source | Wiley Journals |
| subjects | adenocarcinoma Ag nanoparticles Colloids Colon colon tissues Heterogeneity micro-Raman Nanoparticles Raman scattering SERS Silver Spectra Tumors |
| title | Bridging biomolecules with nanoparticles: surface-enhanced Raman scattering from colon carcinoma and normal tissue |
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