Compatibility studies between captopril and pharmaceutical excipients used in tablets formulations
Captopril (CAP) was the first commercially available angiotensine-converting enzyme (ACE) inhibitor. In the anti-hypertensive therapy is considered the selected drug has to be therapeutically effective together with reduced toxicity. CAP is an antihypertensive drug currently being administered in ta...
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| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2008, Vol.91 (1), p.323-328 |
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| container_title | Journal of thermal analysis and calorimetry |
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| creator | Stulzer, H. K. Rodrigues, P. O. Cardoso, T. M. Matos, J. S. R. Silva, M. A. S. |
| description | Captopril (CAP) was the first commercially available angiotensine-converting enzyme (ACE) inhibitor. In the anti-hypertensive therapy is considered the selected drug has to be therapeutically effective together with reduced toxicity. CAP is an antihypertensive drug currently being administered in tablet form. In order to investigate the possible interactions between CAP and excipients in tablets formulations, differential scanning calorimetry (DSC) and thermogravimetric (TG) analysis completed by X-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FTIR) were used for compatibility studies. A possible drug-excipient interaction was observed with magnesium stearate by DSC technique. |
| doi_str_mv | 10.1007/s10973-006-7935-1 |
| format | Article |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Analysis Analytical Chemistry Biological and medical sciences Chemistry Chemistry and Materials Science General pharmacology Inorganic Chemistry Measurement Science and Instrumentation Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical Chemistry Polymer Sciences Regular Papers |
| title | Compatibility studies between captopril and pharmaceutical excipients used in tablets formulations |
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