Blood Levels of Polycyclic Aromatic Hydrocarbons in Children of Lucknow, India
Polycyclic aromatic hydrocarbons (PAHs) are compounds with two or more fused benzene rings produced by incomplete combustion of organic substances involved in natural and anthropogenic processes. Children are exposed to these compounds through inhalation, dietary ingestion, and, also, soil at the pl...
Gespeichert in:
| Veröffentlicht in: | Archives of environmental contamination and toxicology 2008-02, Vol.54 (2), p.348-354 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 354 |
|---|---|
| container_issue | 2 |
| container_start_page | 348 |
| container_title | Archives of environmental contamination and toxicology |
| container_volume | 54 |
| creator | Singh, Vipul K Patel, Devendra K Ram, S Mathur, N Siddiqui, M. K. J Behari, Jai Raj |
| description | Polycyclic aromatic hydrocarbons (PAHs) are compounds with two or more fused benzene rings produced by incomplete combustion of organic substances involved in natural and anthropogenic processes. Children are exposed to these compounds through inhalation, dietary ingestion, and, also, soil at the playground. It has been well established that PAHs have carcinogenic, mutagenic, and teratogenic effects. Considering possible health risks due to PAHs exposure among children, the present study was carried out in collaboration with the Pediatrics Department, King George's Medical University (KGMU), Lucknow, to determine its exposure in children by estimating blood PAHs levels. Due to the variable composition of PAHs mixtures emitted from different environmental sources, any single compound or metabolite may not be representative of all exposure conditions. For these reasons, the measurement of blood PAHs levels as a possible biomarker, especially of the EPA (Environmental Protection Agency, USA) priority list, has been proposed. Acenaphthylene, anthracene, phenanthrene, fluoranthene, naphthalene, pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, and benzo(a)pyrene were determined by HPLC-FD/UV. On the basis of the individual compound, the median (50th percentile) of naphthalene (19 ppb) was highest, however, benzo(a)pyrene (4.0 ppb) level was found to be lowest among all detected PAHs. The median level of total noncarcinogenic PAHs (113.55 ppb) was higher than the total carcinogenic PAHs (32.35 ppb) in blood samples of children. A significant correlation was found between period of time spent in the surrounding breathing zone of the cooking place and total noncarcinogenic PAHs (p < 0.05), while the blood carcinogenic PAHs level in children was found to be associated with lower status of their families (p < 0.05). It is speculated that there may be chances of health hazards through exposure to PAHs, those not yet declared hazardous and present at higher concentrations in the Indian environment. Further study with a larger sample size and accompanying environmental data is desired to validate the findings of this pilot study and strengthen the database of PAHs exposure in India. |
| doi_str_mv | 10.1007/s00244-007-9015-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_31711836</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14846982</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-b9bc60ca31fcecde695e067fe0be0bae3bb5f3c70df98f41ed2883d37970bc883</originalsourceid><addsrcrecordid>eNqFkV9rFDEUxYModq1-AF90EPTJ0XuT7CR5rIvawqKC9jlk8qdOzU5qsqPstzfDLBZ8sBDIgfzuOTccQp4ivEEA8bYAUM7bKlsFuG7ZPbJCzmgLAth9sgJQ0HLG8YQ8KuUaAKmU_CE5QSE6JqVYkU_vYkqu2fpfPpYmheZLigd7sHGwzVlOO7Ov4vzgcrIm92kszTA2m-9DdNmPM7-d7I8x_X7dXIxuMI_Jg2Bi8U-O9ym5_PD-2-a83X7-eLE527Z2jd2-7VVvO7CGYbDeOt-ptYdOBA99Pcazvl8HZgW4oGTg6F1dnDkmlIDeVnlKXi2-Nzn9nHzZ691QrI_RjD5NRTMUiJJ1d4IUFBVS4J0gcsk7JWkFX_wDXqcpj_W3sxmvK-Iciwtkcyol-6Bv8rAz-aAR9NydXrrTs5y706zOPDsaT_3Ou9uJY1kVeHkETLEmhmxGO5S_HAVEqvgcTheu1KfxyufbDf-X_nwZCiZpc5Wr8eXXaskAJBeUKfYHbiq5HQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>209479716</pqid></control><display><type>article</type><title>Blood Levels of Polycyclic Aromatic Hydrocarbons in Children of Lucknow, India</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Singh, Vipul K ; Patel, Devendra K ; Ram, S ; Mathur, N ; Siddiqui, M. K. J ; Behari, Jai Raj</creator><creatorcontrib>Singh, Vipul K ; Patel, Devendra K ; Ram, S ; Mathur, N ; Siddiqui, M. K. J ; Behari, Jai Raj</creatorcontrib><description>Polycyclic aromatic hydrocarbons (PAHs) are compounds with two or more fused benzene rings produced by incomplete combustion of organic substances involved in natural and anthropogenic processes. Children are exposed to these compounds through inhalation, dietary ingestion, and, also, soil at the playground. It has been well established that PAHs have carcinogenic, mutagenic, and teratogenic effects. Considering possible health risks due to PAHs exposure among children, the present study was carried out in collaboration with the Pediatrics Department, King George's Medical University (KGMU), Lucknow, to determine its exposure in children by estimating blood PAHs levels. Due to the variable composition of PAHs mixtures emitted from different environmental sources, any single compound or metabolite may not be representative of all exposure conditions. For these reasons, the measurement of blood PAHs levels as a possible biomarker, especially of the EPA (Environmental Protection Agency, USA) priority list, has been proposed. Acenaphthylene, anthracene, phenanthrene, fluoranthene, naphthalene, pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, and benzo(a)pyrene were determined by HPLC-FD/UV. On the basis of the individual compound, the median (50th percentile) of naphthalene (19 ppb) was highest, however, benzo(a)pyrene (4.0 ppb) level was found to be lowest among all detected PAHs. The median level of total noncarcinogenic PAHs (113.55 ppb) was higher than the total carcinogenic PAHs (32.35 ppb) in blood samples of children. A significant correlation was found between period of time spent in the surrounding breathing zone of the cooking place and total noncarcinogenic PAHs (p < 0.05), while the blood carcinogenic PAHs level in children was found to be associated with lower status of their families (p < 0.05). It is speculated that there may be chances of health hazards through exposure to PAHs, those not yet declared hazardous and present at higher concentrations in the Indian environment. Further study with a larger sample size and accompanying environmental data is desired to validate the findings of this pilot study and strengthen the database of PAHs exposure in India.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/s00244-007-9015-3</identifier><identifier>PMID: 17763887</identifier><identifier>CODEN: AECTCV</identifier><language>eng</language><publisher>New York: New York : Springer-Verlag</publisher><subject>Animal, plant and microbial ecology ; Anthracene ; Anthropogenic factors ; Applied ecology ; Benzene ; Biological and medical sciences ; Blood ; Carcinogens ; Chemical contaminants ; Child ; Child, Preschool ; children ; Earth and Environmental Science ; Ecotoxicology ; Ecotoxicology, biological effects of pollution ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental Monitoring ; Environmental Pollutants - blood ; Environmental Pollutants - chemistry ; Environmental protection ; Exposure ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects ; Health hazards ; Health risks ; Humans ; India ; Ingestion ; Inhalation ; Liquid chromatography ; Male ; Metabolites ; Molecular Weight ; Monitoring/Environmental Analysis ; Naphthalene ; Pediatrics ; Phenanthrene ; Pollution ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - blood ; Polycyclic Aromatic Hydrocarbons - chemistry ; Pyrene ; Research centers ; Soil Science & Conservation ; Studies ; Toxicology</subject><ispartof>Archives of environmental contamination and toxicology, 2008-02, Vol.54 (2), p.348-354</ispartof><rights>Springer Science+Business Media, LLC 2007</rights><rights>2008 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-b9bc60ca31fcecde695e067fe0be0bae3bb5f3c70df98f41ed2883d37970bc883</citedby><cites>FETCH-LOGICAL-c516t-b9bc60ca31fcecde695e067fe0be0bae3bb5f3c70df98f41ed2883d37970bc883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00244-007-9015-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00244-007-9015-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20112946$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17763887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Vipul K</creatorcontrib><creatorcontrib>Patel, Devendra K</creatorcontrib><creatorcontrib>Ram, S</creatorcontrib><creatorcontrib>Mathur, N</creatorcontrib><creatorcontrib>Siddiqui, M. K. J</creatorcontrib><creatorcontrib>Behari, Jai Raj</creatorcontrib><title>Blood Levels of Polycyclic Aromatic Hydrocarbons in Children of Lucknow, India</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><addtitle>Arch Environ Contam Toxicol</addtitle><description>Polycyclic aromatic hydrocarbons (PAHs) are compounds with two or more fused benzene rings produced by incomplete combustion of organic substances involved in natural and anthropogenic processes. Children are exposed to these compounds through inhalation, dietary ingestion, and, also, soil at the playground. It has been well established that PAHs have carcinogenic, mutagenic, and teratogenic effects. Considering possible health risks due to PAHs exposure among children, the present study was carried out in collaboration with the Pediatrics Department, King George's Medical University (KGMU), Lucknow, to determine its exposure in children by estimating blood PAHs levels. Due to the variable composition of PAHs mixtures emitted from different environmental sources, any single compound or metabolite may not be representative of all exposure conditions. For these reasons, the measurement of blood PAHs levels as a possible biomarker, especially of the EPA (Environmental Protection Agency, USA) priority list, has been proposed. Acenaphthylene, anthracene, phenanthrene, fluoranthene, naphthalene, pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, and benzo(a)pyrene were determined by HPLC-FD/UV. On the basis of the individual compound, the median (50th percentile) of naphthalene (19 ppb) was highest, however, benzo(a)pyrene (4.0 ppb) level was found to be lowest among all detected PAHs. The median level of total noncarcinogenic PAHs (113.55 ppb) was higher than the total carcinogenic PAHs (32.35 ppb) in blood samples of children. A significant correlation was found between period of time spent in the surrounding breathing zone of the cooking place and total noncarcinogenic PAHs (p < 0.05), while the blood carcinogenic PAHs level in children was found to be associated with lower status of their families (p < 0.05). It is speculated that there may be chances of health hazards through exposure to PAHs, those not yet declared hazardous and present at higher concentrations in the Indian environment. Further study with a larger sample size and accompanying environmental data is desired to validate the findings of this pilot study and strengthen the database of PAHs exposure in India.</description><subject>Animal, plant and microbial ecology</subject><subject>Anthracene</subject><subject>Anthropogenic factors</subject><subject>Applied ecology</subject><subject>Benzene</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Carcinogens</subject><subject>Chemical contaminants</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental Monitoring</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - chemistry</subject><subject>Environmental protection</subject><subject>Exposure</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Health hazards</subject><subject>Health risks</subject><subject>Humans</subject><subject>India</subject><subject>Ingestion</subject><subject>Inhalation</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>Metabolites</subject><subject>Molecular Weight</subject><subject>Monitoring/Environmental Analysis</subject><subject>Naphthalene</subject><subject>Pediatrics</subject><subject>Phenanthrene</subject><subject>Pollution</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - blood</subject><subject>Polycyclic Aromatic Hydrocarbons - chemistry</subject><subject>Pyrene</subject><subject>Research centers</subject><subject>Soil Science & Conservation</subject><subject>Studies</subject><subject>Toxicology</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkV9rFDEUxYModq1-AF90EPTJ0XuT7CR5rIvawqKC9jlk8qdOzU5qsqPstzfDLBZ8sBDIgfzuOTccQp4ivEEA8bYAUM7bKlsFuG7ZPbJCzmgLAth9sgJQ0HLG8YQ8KuUaAKmU_CE5QSE6JqVYkU_vYkqu2fpfPpYmheZLigd7sHGwzVlOO7Ov4vzgcrIm92kszTA2m-9DdNmPM7-d7I8x_X7dXIxuMI_Jg2Bi8U-O9ym5_PD-2-a83X7-eLE527Z2jd2-7VVvO7CGYbDeOt-ptYdOBA99Pcazvl8HZgW4oGTg6F1dnDkmlIDeVnlKXi2-Nzn9nHzZ691QrI_RjD5NRTMUiJJ1d4IUFBVS4J0gcsk7JWkFX_wDXqcpj_W3sxmvK-Iciwtkcyol-6Bv8rAz-aAR9NydXrrTs5y706zOPDsaT_3Ou9uJY1kVeHkETLEmhmxGO5S_HAVEqvgcTheu1KfxyufbDf-X_nwZCiZpc5Wr8eXXaskAJBeUKfYHbiq5HQ</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Singh, Vipul K</creator><creator>Patel, Devendra K</creator><creator>Ram, S</creator><creator>Mathur, N</creator><creator>Siddiqui, M. K. J</creator><creator>Behari, Jai Raj</creator><general>New York : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7ST</scope><scope>SOI</scope><scope>7QH</scope><scope>KR7</scope></search><sort><creationdate>20080201</creationdate><title>Blood Levels of Polycyclic Aromatic Hydrocarbons in Children of Lucknow, India</title><author>Singh, Vipul K ; Patel, Devendra K ; Ram, S ; Mathur, N ; Siddiqui, M. K. J ; Behari, Jai Raj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-b9bc60ca31fcecde695e067fe0be0bae3bb5f3c70df98f41ed2883d37970bc883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Anthracene</topic><topic>Anthropogenic factors</topic><topic>Applied ecology</topic><topic>Benzene</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Carcinogens</topic><topic>Chemical contaminants</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental Monitoring</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - chemistry</topic><topic>Environmental protection</topic><topic>Exposure</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Health hazards</topic><topic>Health risks</topic><topic>Humans</topic><topic>India</topic><topic>Ingestion</topic><topic>Inhalation</topic><topic>Liquid chromatography</topic><topic>Male</topic><topic>Metabolites</topic><topic>Molecular Weight</topic><topic>Monitoring/Environmental Analysis</topic><topic>Naphthalene</topic><topic>Pediatrics</topic><topic>Phenanthrene</topic><topic>Pollution</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - blood</topic><topic>Polycyclic Aromatic Hydrocarbons - chemistry</topic><topic>Pyrene</topic><topic>Research centers</topic><topic>Soil Science & Conservation</topic><topic>Studies</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Vipul K</creatorcontrib><creatorcontrib>Patel, Devendra K</creatorcontrib><creatorcontrib>Ram, S</creatorcontrib><creatorcontrib>Mathur, N</creatorcontrib><creatorcontrib>Siddiqui, M. K. J</creatorcontrib><creatorcontrib>Behari, Jai Raj</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><collection>Environment Abstracts</collection><collection>Aqualine</collection><collection>Civil Engineering Abstracts</collection><jtitle>Archives of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Vipul K</au><au>Patel, Devendra K</au><au>Ram, S</au><au>Mathur, N</au><au>Siddiqui, M. K. J</au><au>Behari, Jai Raj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood Levels of Polycyclic Aromatic Hydrocarbons in Children of Lucknow, India</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><stitle>Arch Environ Contam Toxicol</stitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>54</volume><issue>2</issue><spage>348</spage><epage>354</epage><pages>348-354</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><coden>AECTCV</coden><abstract>Polycyclic aromatic hydrocarbons (PAHs) are compounds with two or more fused benzene rings produced by incomplete combustion of organic substances involved in natural and anthropogenic processes. Children are exposed to these compounds through inhalation, dietary ingestion, and, also, soil at the playground. It has been well established that PAHs have carcinogenic, mutagenic, and teratogenic effects. Considering possible health risks due to PAHs exposure among children, the present study was carried out in collaboration with the Pediatrics Department, King George's Medical University (KGMU), Lucknow, to determine its exposure in children by estimating blood PAHs levels. Due to the variable composition of PAHs mixtures emitted from different environmental sources, any single compound or metabolite may not be representative of all exposure conditions. For these reasons, the measurement of blood PAHs levels as a possible biomarker, especially of the EPA (Environmental Protection Agency, USA) priority list, has been proposed. Acenaphthylene, anthracene, phenanthrene, fluoranthene, naphthalene, pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, and benzo(a)pyrene were determined by HPLC-FD/UV. On the basis of the individual compound, the median (50th percentile) of naphthalene (19 ppb) was highest, however, benzo(a)pyrene (4.0 ppb) level was found to be lowest among all detected PAHs. The median level of total noncarcinogenic PAHs (113.55 ppb) was higher than the total carcinogenic PAHs (32.35 ppb) in blood samples of children. A significant correlation was found between period of time spent in the surrounding breathing zone of the cooking place and total noncarcinogenic PAHs (p < 0.05), while the blood carcinogenic PAHs level in children was found to be associated with lower status of their families (p < 0.05). It is speculated that there may be chances of health hazards through exposure to PAHs, those not yet declared hazardous and present at higher concentrations in the Indian environment. Further study with a larger sample size and accompanying environmental data is desired to validate the findings of this pilot study and strengthen the database of PAHs exposure in India.</abstract><cop>New York</cop><pub>New York : Springer-Verlag</pub><pmid>17763887</pmid><doi>10.1007/s00244-007-9015-3</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-4341 |
| ispartof | Archives of environmental contamination and toxicology, 2008-02, Vol.54 (2), p.348-354 |
| issn | 0090-4341 1432-0703 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_31711836 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animal, plant and microbial ecology Anthracene Anthropogenic factors Applied ecology Benzene Biological and medical sciences Blood Carcinogens Chemical contaminants Child Child, Preschool children Earth and Environmental Science Ecotoxicology Ecotoxicology, biological effects of pollution Environment Environmental Chemistry Environmental Health Environmental Monitoring Environmental Pollutants - blood Environmental Pollutants - chemistry Environmental protection Exposure Female Fundamental and applied biological sciences. Psychology General aspects Health hazards Health risks Humans India Ingestion Inhalation Liquid chromatography Male Metabolites Molecular Weight Monitoring/Environmental Analysis Naphthalene Pediatrics Phenanthrene Pollution Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - blood Polycyclic Aromatic Hydrocarbons - chemistry Pyrene Research centers Soil Science & Conservation Studies Toxicology |
| title | Blood Levels of Polycyclic Aromatic Hydrocarbons in Children of Lucknow, India |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T01%3A39%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Blood%20Levels%20of%20Polycyclic%20Aromatic%20Hydrocarbons%20in%20Children%20of%20Lucknow,%20India&rft.jtitle=Archives%20of%20environmental%20contamination%20and%20toxicology&rft.au=Singh,%20Vipul%20K&rft.date=2008-02-01&rft.volume=54&rft.issue=2&rft.spage=348&rft.epage=354&rft.pages=348-354&rft.issn=0090-4341&rft.eissn=1432-0703&rft.coden=AECTCV&rft_id=info:doi/10.1007/s00244-007-9015-3&rft_dat=%3Cproquest_cross%3E14846982%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=209479716&rft_id=info:pmid/17763887&rfr_iscdi=true |