Biodegradable poly(sebacic acid-co-ricinoleic-ester anhydride) tamoxifen citrate implants: Preparation and in vitro characterization
The aim of this study was to prepare tamoxifen citrate loaded cylindrical polymeric implants for application at tumor sites. The implant was based on poly (sebacic acid-co-ricinoleic-ester anhydride) 70 : 30 w/w [poly(SA-RA) 70 : 30 w/w], a low-melting, biodegradable, and biocompatible polymer. Impl...
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| Veröffentlicht in: | Journal of applied polymer science 2008-03, Vol.107 (5), p.2745-2754 |
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| creator | Hiremath, J.G Kusum Devi, V Devi, Kshama Domb, A.J |
| description | The aim of this study was to prepare tamoxifen citrate loaded cylindrical polymeric implants for application at tumor sites. The implant was based on poly (sebacic acid-co-ricinoleic-ester anhydride) 70 : 30 w/w [poly(SA-RA) 70 : 30 w/w], a low-melting, biodegradable, and biocompatible polymer. Implants were prepared by a standardized melt manufacturing method. Differential scanning calorimetry and scanning electron microscopy were used for implant characterization. In vitro drug release studies were performed in phosphate-buffered saline (pH 7.4) at 37 ± 2°C. The drug content was estimated by high-performance liquid chromatography. The differential scanning calorimetry studies showed that the tamoxifen citrate in the implants was in the amorphous state. The cumulative percentage of drug release from 10 and 20 wt % drug-loaded poly(SA-RA) 70 : 30 w/w implants after 30 days was found to be 42.36 and 62.60%, respectively. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 |
| doi_str_mv | 10.1002/app.27391 |
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The implant was based on poly (sebacic acid-co-ricinoleic-ester anhydride) 70 : 30 w/w [poly(SA-RA) 70 : 30 w/w], a low-melting, biodegradable, and biocompatible polymer. Implants were prepared by a standardized melt manufacturing method. Differential scanning calorimetry and scanning electron microscopy were used for implant characterization. In vitro drug release studies were performed in phosphate-buffered saline (pH 7.4) at 37 ± 2°C. The drug content was estimated by high-performance liquid chromatography. The differential scanning calorimetry studies showed that the tamoxifen citrate in the implants was in the amorphous state. The cumulative percentage of drug release from 10 and 20 wt % drug-loaded poly(SA-RA) 70 : 30 w/w implants after 30 days was found to be 42.36 and 62.60%, respectively. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.27391</identifier><identifier>CODEN: JAPNAB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Applied sciences ; biodegradable ; Biological and medical sciences ; drug delivery systems ; Exact sciences and technology ; Forms of application and semi-finished materials ; General pharmacology ; implant ; injection molding ; Medical sciences ; Miscellaneous ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polymer industry, paints, wood ; Technology of polymers</subject><ispartof>Journal of applied polymer science, 2008-03, Vol.107 (5), p.2745-2754</ispartof><rights>Copyright © 2007 Wiley Periodicals, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4641-f072ce6c8ecccd2e41e1b2e8411ea9574dceca4c922cd966a18f79a4521973003</citedby><cites>FETCH-LOGICAL-c4641-f072ce6c8ecccd2e41e1b2e8411ea9574dceca4c922cd966a18f79a4521973003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.27391$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.27391$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20043288$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Hiremath, J.G</creatorcontrib><creatorcontrib>Kusum Devi, V</creatorcontrib><creatorcontrib>Devi, Kshama</creatorcontrib><creatorcontrib>Domb, A.J</creatorcontrib><title>Biodegradable poly(sebacic acid-co-ricinoleic-ester anhydride) tamoxifen citrate implants: Preparation and in vitro characterization</title><title>Journal of applied polymer science</title><addtitle>J. Appl. Polym. Sci</addtitle><description>The aim of this study was to prepare tamoxifen citrate loaded cylindrical polymeric implants for application at tumor sites. The implant was based on poly (sebacic acid-co-ricinoleic-ester anhydride) 70 : 30 w/w [poly(SA-RA) 70 : 30 w/w], a low-melting, biodegradable, and biocompatible polymer. Implants were prepared by a standardized melt manufacturing method. Differential scanning calorimetry and scanning electron microscopy were used for implant characterization. In vitro drug release studies were performed in phosphate-buffered saline (pH 7.4) at 37 ± 2°C. The drug content was estimated by high-performance liquid chromatography. The differential scanning calorimetry studies showed that the tamoxifen citrate in the implants was in the amorphous state. The cumulative percentage of drug release from 10 and 20 wt % drug-loaded poly(SA-RA) 70 : 30 w/w implants after 30 days was found to be 42.36 and 62.60%, respectively. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008</description><subject>Applied sciences</subject><subject>biodegradable</subject><subject>Biological and medical sciences</subject><subject>drug delivery systems</subject><subject>Exact sciences and technology</subject><subject>Forms of application and semi-finished materials</subject><subject>General pharmacology</subject><subject>implant</subject><subject>injection molding</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymer industry, paints, wood</subject><subject>Technology of polymers</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkUFv1DAQhSMEEkvhwC_AFxA9pLUdx465tSsoSCtYCaoerdnJpDVk42Cn0OXMD8fblN4QF1ua-d7zeF5RPBf8SHAuj2Ecj6SprHhQLAS3plRaNg-LRe6JsrG2flw8Sekr50LUXC-K36c-tHQZoYVNT2wM_e51og2gR5aPtsRQRo9-CD15LClNFBkMV7s2-pYO2QTbcOM7Ghj6KcJEzG_HHoYpvWHrSCPkmg9DlrTMD-xHhgLDq1zG7OR_3XafFo866BM9u7sPivN3b78s35erT2cflierEpVWouy4kUgaG0LEVpISJDaSGiUEga2NapEQFFopsbVag2g6Y0HVUlhTcV4dFK9m3zGG79f5L27rE1Kf56VwnVwlDG8q3fwXlFwbo7TO4OEMYgwpRercGP0W4s4J7vaBuByIuw0ksy_vTCEh9F2EAX26F0jOVSWb_ePHM_fT97T7t6E7Wa__Opezwud4bu4VEL85bSpTu4uPZ269Oq2MFkt3kfkXM99BcHAZ8xTnnyUXeUf7ZSpb_QHWl7SV</recordid><startdate>20080305</startdate><enddate>20080305</enddate><creator>Hiremath, J.G</creator><creator>Kusum Devi, V</creator><creator>Devi, Kshama</creator><creator>Domb, A.J</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>JG9</scope></search><sort><creationdate>20080305</creationdate><title>Biodegradable poly(sebacic acid-co-ricinoleic-ester anhydride) tamoxifen citrate implants: Preparation and in vitro characterization</title><author>Hiremath, J.G ; Kusum Devi, V ; Devi, Kshama ; Domb, A.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4641-f072ce6c8ecccd2e41e1b2e8411ea9574dceca4c922cd966a18f79a4521973003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Applied sciences</topic><topic>biodegradable</topic><topic>Biological and medical sciences</topic><topic>drug delivery systems</topic><topic>Exact sciences and technology</topic><topic>Forms of application and semi-finished materials</topic><topic>General pharmacology</topic><topic>implant</topic><topic>injection molding</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymer industry, paints, wood</topic><topic>Technology of polymers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hiremath, J.G</creatorcontrib><creatorcontrib>Kusum Devi, V</creatorcontrib><creatorcontrib>Devi, Kshama</creatorcontrib><creatorcontrib>Domb, A.J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hiremath, J.G</au><au>Kusum Devi, V</au><au>Devi, Kshama</au><au>Domb, A.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biodegradable poly(sebacic acid-co-ricinoleic-ester anhydride) tamoxifen citrate implants: Preparation and in vitro characterization</atitle><jtitle>Journal of applied polymer science</jtitle><addtitle>J. Appl. Polym. Sci</addtitle><date>2008-03-05</date><risdate>2008</risdate><volume>107</volume><issue>5</issue><spage>2745</spage><epage>2754</epage><pages>2745-2754</pages><issn>0021-8995</issn><eissn>1097-4628</eissn><coden>JAPNAB</coden><abstract>The aim of this study was to prepare tamoxifen citrate loaded cylindrical polymeric implants for application at tumor sites. The implant was based on poly (sebacic acid-co-ricinoleic-ester anhydride) 70 : 30 w/w [poly(SA-RA) 70 : 30 w/w], a low-melting, biodegradable, and biocompatible polymer. Implants were prepared by a standardized melt manufacturing method. Differential scanning calorimetry and scanning electron microscopy were used for implant characterization. In vitro drug release studies were performed in phosphate-buffered saline (pH 7.4) at 37 ± 2°C. The drug content was estimated by high-performance liquid chromatography. The differential scanning calorimetry studies showed that the tamoxifen citrate in the implants was in the amorphous state. The cumulative percentage of drug release from 10 and 20 wt % drug-loaded poly(SA-RA) 70 : 30 w/w implants after 30 days was found to be 42.36 and 62.60%, respectively. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/app.27391</doi><tpages>10</tpages></addata></record> |
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| subjects | Applied sciences biodegradable Biological and medical sciences drug delivery systems Exact sciences and technology Forms of application and semi-finished materials General pharmacology implant injection molding Medical sciences Miscellaneous Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymer industry, paints, wood Technology of polymers |
| title | Biodegradable poly(sebacic acid-co-ricinoleic-ester anhydride) tamoxifen citrate implants: Preparation and in vitro characterization |
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