The landscape of autosomal-dominant Alzheimer's disease: global distribution and age of onset

We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer's disease (ADAD). A total of 550 variants in the APP, PSEN1, and PSEN2 genes were identified, of which 279 were classified as pathogenic or likely pathogenic based on ACMG-AMP criteria, u...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2025-02
Hauptverfasser:	Liu, Haiyan, Marsh, Thomas W, Shi, Xinyu, Renton, Alan E, Bowling, Kevin M, Ziegemeier, Ellen, Wang, Guoqiao, Cao, Yuchen, Aristel, Alisha, Li, Jessie, Dickson, Alexa, Perrin, Richard J, Goate, Alison M, Fernández, Victoria, Day, Gregory S, Doering, Michelle, Daniels, Alisha, Gordon, Brian A, Benzinger, Tammie L S, Hassenstab, Jason, Ibanez, Laura, Supnet-Bell, Charlene, Xiong, Chengjie, Allegri, Ricardo, Berman, Sarah B, Fox, Nick C, Ryan, Natalie, Huey, Edward D, Vöglein, Jonathan, Noble, James M, Roh, Jee Hoon, Jucker, Mathias, Laske, Christoph, Ikeuchi, Takeshi, Sanchez-Valle, Raquel, Schofield, Peter R, Chrem Mendez, Patricio, Chhatwal, Jasmeer P, Farlow, Martin, Lee, Jae-Hong, Levey, Allan I, Levin, Johannes, Lopera, Francisco, Martins, Ralph, Niimi, Yoshiki, Rosa-Neto, Pedro, Morris, John C, Bateman, Randall J, Karch, Celeste M, Cruchaga, Carlos, McDade, Eric, Llibre-Guerra, Jorge J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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