The role of spatial arrangement of aromatic rings on the binding of N , N '-diheteroaryl guanidine ligands to the G2C4/G2C4 motif DNA

Non-canonical DNA structures formed by aberrantly expanded repeat DNA are implicated in promoting repeat instability and the onset of repeat expansion diseases. Small molecules that target these disease-causing repeat DNAs hold promise as therapeutic agents for such diseases. Specifically, 1,3-di(qu...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2025-01
Hauptverfasser:	Murakami, Eitaro, Shibata, Tomonori, Tomemori, Megumi, Kawai, Gota, Nakatani, Kazuhiko
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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