Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies?
A-kinase anchoring protein 79/150 (AKAP79/150) is a crucial scaffolding protein that positions various proteins at specific synaptic sites to modulate excitatory synaptic intensity. As our understanding of AKAP79/150's biology deepens, along with its significant role in the pathophysiology of v...
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| Veröffentlicht in: | Neurobiology of disease 2025-03, Vol.206, p.106812, Article 106812 |
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| container_title | Neurobiology of disease |
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| creator | Chu, Chen-Chao Hu, Ya-Hui Li, Gui-Zhou Chen, Jiang Zhang, Ning-Ning Gu, Yi-Xue Wu, Shi-Yu Zhang, Hai-Feng Xu, Yang-Yang Guo, Hong-Li Tian, Xin Chen, Feng |
| description | A-kinase anchoring protein 79/150 (AKAP79/150) is a crucial scaffolding protein that positions various proteins at specific synaptic sites to modulate excitatory synaptic intensity. As our understanding of AKAP79/150's biology deepens, along with its significant role in the pathophysiology of various human disorders, there is growing evidence that reveals new opportunities for therapeutic interventions. In this review, we examine the fundamental structure and primary functions of AKAP79/150, emphasizing its pathophysiological mechanisms in different nervous system disorders, particularly inflammatory pain, epilepsy, depression, and Alzheimer's disease. We also discuss its potential therapeutic implications for patients suffering from these conditions. |
| doi_str_mv | 10.1016/j.nbd.2025.106812 |
| format | Article |
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We also discuss its potential therapeutic implications for patients suffering from these conditions.</description><subject>AKAP79/150</subject><subject>Depression</subject><subject>Epilepsy</subject><subject>Inflammatory pain</subject><subject>Potential therapeutics</subject><subject>Structure and biological functions</subject><issn>0969-9961</issn><issn>1095-953X</issn><issn>1095-953X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kU1v1DAQhiMEokvhB3BBPnLJ1o5jx4YDWlV8VFSCA5W4WY49XrxK7GAni_bf421Kj5yssd55RjNPVb0meEsw4VeHbejttsENKzUXpHlSbQiWrJaM_nxabbDkspaSk4vqRc4HjAlhsnteXVApeMuablP9uQtH8IMPezT_ApT9PnjnjQ4GUHRo93X3vZNXhGHkw30iQDrGJaN8yjOMyPock4WU36FdQDBC2p9ZcZpimpfg5xNyMSG3zEuCMyDpyUP-8LJ65vSQ4dXDe1ndffr44_pLffvt88317rY2DZNN3dPGGoml4USwRnCnhXAdMy1YB5ZiMB01upWYux4T11njHHeSUipNK7Sjl9XNyrVRH9SU_KjTSUXt1f1HTHul0-zNAIqxTlgnSO9E2xKp-4LgXBoiGeHg2sJ6u7KmFH8vkGc1-mxgGHSAchJFCcdFQ8dEiZI1alLMOYF7HE2wOrtTB1XcqbM7tborPW8e8Es_gn3s-CerBN6vASgHO3pIKhsPxZT1CcxcNvL_wf8FZkGqEQ</recordid><startdate>20250301</startdate><enddate>20250301</enddate><creator>Chu, Chen-Chao</creator><creator>Hu, Ya-Hui</creator><creator>Li, Gui-Zhou</creator><creator>Chen, Jiang</creator><creator>Zhang, Ning-Ning</creator><creator>Gu, Yi-Xue</creator><creator>Wu, Shi-Yu</creator><creator>Zhang, Hai-Feng</creator><creator>Xu, Yang-Yang</creator><creator>Guo, Hong-Li</creator><creator>Tian, Xin</creator><creator>Chen, Feng</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20250301</creationdate><title>Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies?</title><author>Chu, Chen-Chao ; Hu, Ya-Hui ; Li, Gui-Zhou ; Chen, Jiang ; Zhang, Ning-Ning ; Gu, Yi-Xue ; Wu, Shi-Yu ; Zhang, Hai-Feng ; Xu, Yang-Yang ; Guo, Hong-Li ; Tian, Xin ; Chen, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2592-b32dc909c6185286fa88f75c4edfed30ec73ca4906fb01f7dcff6f93339c48af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>AKAP79/150</topic><topic>Depression</topic><topic>Epilepsy</topic><topic>Inflammatory pain</topic><topic>Potential therapeutics</topic><topic>Structure and biological functions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chu, Chen-Chao</creatorcontrib><creatorcontrib>Hu, Ya-Hui</creatorcontrib><creatorcontrib>Li, Gui-Zhou</creatorcontrib><creatorcontrib>Chen, Jiang</creatorcontrib><creatorcontrib>Zhang, Ning-Ning</creatorcontrib><creatorcontrib>Gu, Yi-Xue</creatorcontrib><creatorcontrib>Wu, Shi-Yu</creatorcontrib><creatorcontrib>Zhang, Hai-Feng</creatorcontrib><creatorcontrib>Xu, Yang-Yang</creatorcontrib><creatorcontrib>Guo, Hong-Li</creatorcontrib><creatorcontrib>Tian, Xin</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Neurobiology of disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chu, Chen-Chao</au><au>Hu, Ya-Hui</au><au>Li, Gui-Zhou</au><au>Chen, Jiang</au><au>Zhang, Ning-Ning</au><au>Gu, Yi-Xue</au><au>Wu, Shi-Yu</au><au>Zhang, Hai-Feng</au><au>Xu, Yang-Yang</au><au>Guo, Hong-Li</au><au>Tian, Xin</au><au>Chen, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies?</atitle><jtitle>Neurobiology of disease</jtitle><addtitle>Neurobiol Dis</addtitle><date>2025-03-01</date><risdate>2025</risdate><volume>206</volume><spage>106812</spage><pages>106812-</pages><artnum>106812</artnum><issn>0969-9961</issn><issn>1095-953X</issn><eissn>1095-953X</eissn><abstract>A-kinase anchoring protein 79/150 (AKAP79/150) is a crucial scaffolding protein that positions various proteins at specific synaptic sites to modulate excitatory synaptic intensity. 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| source | DOAJ Directory of Open Access Journals; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | AKAP79/150 Depression Epilepsy Inflammatory pain Potential therapeutics Structure and biological functions |
| title | Unveiling the significance of AKAP79/150 in the nervous system disorders: An emerging opportunity for future therapies? |
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