Nicotinamide Mononucleotide Restores NAD + Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells

Inflammation disrupts the normal function of granulosa cells (GCs), which leads to ovarian dysfunction and fertility decline. Inflammatory conditions such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI), endometriosis, and age-related ovarian decline are often associated wit...

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Veröffentlicht in:	Antioxidants 2024-12, Vol.14 (1), p.39
Hauptverfasser:	Ahmed, Mehboob, Riaz, Umair, Lv, Haimiao, Amjad, Muhammad, Ahmed, Sohail, Ali, Shaokat, Ghani, Muhammad Usman, Hua, Guohua, Yang, Liguo
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Age Apoptosis BAX protein Bcl-2 protein Caspase-3 Caspase-9 Cell culture Cell viability Cyclooxygenase-2 Endometriosis Fertility Gene expression granulosa cell Homeostasis Inflammation Interleukin 1 Interleukin 6 Lipopolysaccharides MAP kinase Membranes Metabolism mRNA NAD NMN Ovaries Oxidative stress Phosphatase Polycystic ovary syndrome Progesterone Reactive oxygen species Reproductive health ROS Senescence Signal transduction Steroidogenesis Supplements TLR4 protein Tumor necrosis factor-α
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