Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion

The hepatocyte growth factor (HGF) along with its receptor (c-MET) are crucial in preserving standard cellular physiological activities, and imbalances in the c-MET signaling pathway can lead to the development and advancement of tumors. It has been extensively demonstrated that immune checkpoint in...

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Veröffentlicht in:	Cell communication and signaling 2025-01, Vol.23 (1), p.46-18, Article 46
Hauptverfasser:	Xia, Yang, Huang, Chunye, Zhong, Min, Zhong, Hongguang, Ruan, Ruiwen, Xiong, Jianping, Yao, Yangyang, Zhou, Jing, Deng, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	1/PD Animals Care and treatment Cellular Cellular signal transduction Development and progression Genetic aspects Growth factors Health aspects Hepatocyte Growth Factor - metabolism Humans Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use L1 inhibitors, c Mesenchymal epithelial transition factor, Tumor microenvironment, PD MET inhibitors, HGF/c MET signaling pathway Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Protein tyrosine kinase Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - metabolism Review Signal Transduction - drug effects Tumor Escape - drug effects Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Tumors
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