The microglial response to inhibition of Colony-stimulating-factor-1 receptor by PLX3397 differs by sex in adult mice

Microglia, the resident macrophages of the brain, are derived from the yolk sac and colonize the brain before the blood-brain barrier forms. Once established, they expand locally and require Colony-stimulating-factor-1 receptor (CSF1R) signaling for their development and maintenance. CSF1R inhibitor...

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Veröffentlicht in:	Cell reports (Cambridge) 2025-01, Vol.44 (1), p.115176, Article 115176
Hauptverfasser:	Le, Linh H.D., Eliseeva, Sophia, Plunk, Elizabeth, Kara-Pabani, Kallam, Li, Herman, Yarovinsky, Felix, Majewska, Ania K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Animals Autophagy - drug effects Colony-stimulating-factor-1 receptor, TREM2, CX3C motif chemokine receptor 1, Galectin-3 Female Male Mice Mice, Inbred C57BL Mice, Transgenic microglia Microglia - drug effects Microglia - metabolism PLX3397 Pyrroles - pharmacology Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Sex Characteristics sex-dependent differences survival signaling
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