Effects of Cholesterol on the Breast Cancer Resistance Protein: Studies through the Synthesis and Biological Evaluation of Chemical Tools

The breast cancer resistance protein (BCRP/ABCG2) plays a major role in the multidrug resistance of cancers toward chemotherapeutic treatments. It was demonstrated that cholesterol regulates the ABCG2 activity, suggesting that lower levels of membrane cholesterol decrease the ABCG2 activity in mamma...

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Veröffentlicht in:	ChemMedChem 2025-01, p.e202400712
Hauptverfasser:	Fatima Zattoni, Ingrid, Estelita Rugisnk, Bruna, da Silva Zanzarini, Isadora, Guilherme Gonçalves, Alan, Rotuno Moure, Vivian, Valdameri, Glaucio, Boumendjel, Ahcène
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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