Pallidal Spike‐Train Variability and Randomness Are the Most Important Signatures to Classify Parkinson's Disease and Cervical Dystonia

ABSTRACT Movement disorders such as Parkinson's disease (PD) and cervical dystonia (CD) are associated with abnormal neuronal activity in the globus pallidus internus (GPi). Reduced firing rate and presence of spiking bursts are typical for CD, whereas PD is characterized by high frequency toni...

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Veröffentlicht in:	The European journal of neuroscience 2025-01, Vol.61 (2), p.e16653-n/a
Hauptverfasser:	Sedov, A., Pavlovsky, P., Filyushkina, V., Dzhalagoniya, I., Semenova, U., Zakharov, N., Gamaleya, A., Tomskiy, A., Shaikh, Aasef G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Adult Aged Cell culture deep brain stimulation Deep Brain Stimulation - methods Dystonia entropy Female Firing pattern Firing rate Globus pallidus Globus Pallidus - physiopathology Humans Male Middle Aged Movement disorders Neurodegenerative diseases Neurons - physiology Parkinson Disease - physiopathology Parkinson's disease Regression analysis single unit activity Torticollis - physiopathology Unit activity
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