Feasibility of Pure Laparoscopic Donor Right Hepatectomy Compared to Open Donor Right Hepatectomy: A Large Single-Center Cohort Study
This study aimed to compare morbidity of living donors and recipients after pure laparoscopic donor right hepatectomy (PLDRH) and open donor right hepatectomy (ODRH). Donor and recipient morbidity have not been sufficiently reported in large-scale comparisons of PLDRH and ODRH. This retrospective st...
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| Veröffentlicht in: | Annals of surgery 2025-01 |
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| creator | Kim, Sang-Hoon Kim, Ki-Hun Yoon, Young-In Kang, Woo-Hyoung Lee, Sang-Kyung Hwang, Shin Ahn, Chul-Soo Moon, Deok-Bog Ha, Tae-Yong Song, Gi-Won Jung, Dong-Hwan Park, Gil-Chun Kim, Ji Hoon Jwa, Eun-Kyoung Na, Byeong-Gon Kim, Sung Min Oh, Rak-Kyun Jeong, I-Ji Ko, Hyo Jung Choi, Minha Won, Dae Hyeon Kang, Ji Hoon Lee, Sung-Gyu |
| description | This study aimed to compare morbidity of living donors and recipients after pure laparoscopic donor right hepatectomy (PLDRH) and open donor right hepatectomy (ODRH).
Donor and recipient morbidity have not been sufficiently reported in large-scale comparisons of PLDRH and ODRH.
This retrospective study reviewed 3348 donors who underwent PLDRH (n=329) and ODRH (n=3019) and their corresponding recipients (n=3348) between January 2014 and August 2023. Donor complications and recipient biliary complications within 90 days were evaluated before and after 1:3 propensity score mathcing (PSM). Multivariate logistic regression analyses identified significant risk factors for donor major and biliary complications, as well as recipient bile leakage and biliary stricture.
For donors, PLDRH had fewer overall complications than ODRH (0.9% vs. 3.7%, P=0.009), with no significant differences in major (Clavien-Dindo III/IV) complications (P=0.057) and biliary complications (P=0.067), despite the absence of biliary complications in PLDRH. However, PLDRH showed longer warm ischemic time and operation time, and higher peak aspartate aminotransferase and alanine aminotransferase levels compared to ODRH in donors (P |
| doi_str_mv | 10.1097/SLA.0000000000006633 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3157549709</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3157549709</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1018-cb383fbde139402fc9e20a20addd1236a2e1a8c28d6c7911a37a6ffb62632fb33</originalsourceid><addsrcrecordid>eNp1kd1Kw0AQhRdRbK2-gcheepO6P2mS9a5Ua4VAxep12GwmbSTJxt3NRR7A93alVURwGBgYvjMD5yB0ScmUEhHfbNL5lPyqKOL8CI3pjCUBpSE5RmO_5UEoOBuhM2vfCKFhQuJTNOIiYSKkyRh9LEHaKq_qyg1Yl_ipN4BT2UmjrdJdpfCdbrXBz9V25_AKOulAOd0MeKEbT0GBncbrDtr_wFs89wfNFvCmarc1BAtoHRiv32nj8Mb1xXCOTkpZW7g4zAl6Xd6_LFZBun54XMzTQFFCk0DlPOFlXgDlIiSsVAIYkb6LoqCMR5IBlYliSRGpWFAqeSyjsswjFnFW5pxP0PX-bmf0ew_WZU1lFdS1bEH3NuN0Fs9CERPh0XCPKu-ENVBmnakaaYaMkuwrgMwHkP0NwMuuDh_6vIHiR_TtOP8EkBCB1A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3157549709</pqid></control><display><type>article</type><title>Feasibility of Pure Laparoscopic Donor Right Hepatectomy Compared to Open Donor Right Hepatectomy: A Large Single-Center Cohort Study</title><source>Journals@Ovid Complete</source><creator>Kim, Sang-Hoon ; Kim, Ki-Hun ; Yoon, Young-In ; Kang, Woo-Hyoung ; Lee, Sang-Kyung ; Hwang, Shin ; Ahn, Chul-Soo ; Moon, Deok-Bog ; Ha, Tae-Yong ; Song, Gi-Won ; Jung, Dong-Hwan ; Park, Gil-Chun ; Kim, Ji Hoon ; Jwa, Eun-Kyoung ; Na, Byeong-Gon ; Kim, Sung Min ; Oh, Rak-Kyun ; Jeong, I-Ji ; Ko, Hyo Jung ; Choi, Minha ; Won, Dae Hyeon ; Kang, Ji Hoon ; Lee, Sung-Gyu</creator><creatorcontrib>Kim, Sang-Hoon ; Kim, Ki-Hun ; Yoon, Young-In ; Kang, Woo-Hyoung ; Lee, Sang-Kyung ; Hwang, Shin ; Ahn, Chul-Soo ; Moon, Deok-Bog ; Ha, Tae-Yong ; Song, Gi-Won ; Jung, Dong-Hwan ; Park, Gil-Chun ; Kim, Ji Hoon ; Jwa, Eun-Kyoung ; Na, Byeong-Gon ; Kim, Sung Min ; Oh, Rak-Kyun ; Jeong, I-Ji ; Ko, Hyo Jung ; Choi, Minha ; Won, Dae Hyeon ; Kang, Ji Hoon ; Lee, Sung-Gyu</creatorcontrib><description>This study aimed to compare morbidity of living donors and recipients after pure laparoscopic donor right hepatectomy (PLDRH) and open donor right hepatectomy (ODRH).
Donor and recipient morbidity have not been sufficiently reported in large-scale comparisons of PLDRH and ODRH.
This retrospective study reviewed 3348 donors who underwent PLDRH (n=329) and ODRH (n=3019) and their corresponding recipients (n=3348) between January 2014 and August 2023. Donor complications and recipient biliary complications within 90 days were evaluated before and after 1:3 propensity score mathcing (PSM). Multivariate logistic regression analyses identified significant risk factors for donor major and biliary complications, as well as recipient bile leakage and biliary stricture.
For donors, PLDRH had fewer overall complications than ODRH (0.9% vs. 3.7%, P=0.009), with no significant differences in major (Clavien-Dindo III/IV) complications (P=0.057) and biliary complications (P=0.067), despite the absence of biliary complications in PLDRH. However, PLDRH showed longer warm ischemic time and operation time, and higher peak aspartate aminotransferase and alanine aminotransferase levels compared to ODRH in donors (P<0.001). These results remained consistent after PSM. Recipient biliary complications were comparable between PLDRH and ODRH, both before (P=0.806) and after PSM (P=0.149). Multiple portal veins were significant donor risk foctor for major (P=0.022), and biliary complications (P=0.001). Separated multiple bile ducts were common significant recipient risk factor for bile leakage (P=0.007) and biliary stricture (P=0.022).
PLDRH could become the standard for donor right hepatectomy with careful consideration of portal and biliary variations for donor and recipient safety.</description><identifier>ISSN: 0003-4932</identifier><identifier>ISSN: 1528-1140</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/SLA.0000000000006633</identifier><identifier>PMID: 39829418</identifier><language>eng</language><publisher>United States</publisher><ispartof>Annals of surgery, 2025-01</ispartof><rights>Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-8025-1816 ; 0000-0002-4016-0995</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39829418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sang-Hoon</creatorcontrib><creatorcontrib>Kim, Ki-Hun</creatorcontrib><creatorcontrib>Yoon, Young-In</creatorcontrib><creatorcontrib>Kang, Woo-Hyoung</creatorcontrib><creatorcontrib>Lee, Sang-Kyung</creatorcontrib><creatorcontrib>Hwang, Shin</creatorcontrib><creatorcontrib>Ahn, Chul-Soo</creatorcontrib><creatorcontrib>Moon, Deok-Bog</creatorcontrib><creatorcontrib>Ha, Tae-Yong</creatorcontrib><creatorcontrib>Song, Gi-Won</creatorcontrib><creatorcontrib>Jung, Dong-Hwan</creatorcontrib><creatorcontrib>Park, Gil-Chun</creatorcontrib><creatorcontrib>Kim, Ji Hoon</creatorcontrib><creatorcontrib>Jwa, Eun-Kyoung</creatorcontrib><creatorcontrib>Na, Byeong-Gon</creatorcontrib><creatorcontrib>Kim, Sung Min</creatorcontrib><creatorcontrib>Oh, Rak-Kyun</creatorcontrib><creatorcontrib>Jeong, I-Ji</creatorcontrib><creatorcontrib>Ko, Hyo Jung</creatorcontrib><creatorcontrib>Choi, Minha</creatorcontrib><creatorcontrib>Won, Dae Hyeon</creatorcontrib><creatorcontrib>Kang, Ji Hoon</creatorcontrib><creatorcontrib>Lee, Sung-Gyu</creatorcontrib><title>Feasibility of Pure Laparoscopic Donor Right Hepatectomy Compared to Open Donor Right Hepatectomy: A Large Single-Center Cohort Study</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>This study aimed to compare morbidity of living donors and recipients after pure laparoscopic donor right hepatectomy (PLDRH) and open donor right hepatectomy (ODRH).
Donor and recipient morbidity have not been sufficiently reported in large-scale comparisons of PLDRH and ODRH.
This retrospective study reviewed 3348 donors who underwent PLDRH (n=329) and ODRH (n=3019) and their corresponding recipients (n=3348) between January 2014 and August 2023. Donor complications and recipient biliary complications within 90 days were evaluated before and after 1:3 propensity score mathcing (PSM). Multivariate logistic regression analyses identified significant risk factors for donor major and biliary complications, as well as recipient bile leakage and biliary stricture.
For donors, PLDRH had fewer overall complications than ODRH (0.9% vs. 3.7%, P=0.009), with no significant differences in major (Clavien-Dindo III/IV) complications (P=0.057) and biliary complications (P=0.067), despite the absence of biliary complications in PLDRH. However, PLDRH showed longer warm ischemic time and operation time, and higher peak aspartate aminotransferase and alanine aminotransferase levels compared to ODRH in donors (P<0.001). These results remained consistent after PSM. Recipient biliary complications were comparable between PLDRH and ODRH, both before (P=0.806) and after PSM (P=0.149). Multiple portal veins were significant donor risk foctor for major (P=0.022), and biliary complications (P=0.001). Separated multiple bile ducts were common significant recipient risk factor for bile leakage (P=0.007) and biliary stricture (P=0.022).
PLDRH could become the standard for donor right hepatectomy with careful consideration of portal and biliary variations for donor and recipient safety.</description><issn>0003-4932</issn><issn>1528-1140</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNp1kd1Kw0AQhRdRbK2-gcheepO6P2mS9a5Ua4VAxep12GwmbSTJxt3NRR7A93alVURwGBgYvjMD5yB0ScmUEhHfbNL5lPyqKOL8CI3pjCUBpSE5RmO_5UEoOBuhM2vfCKFhQuJTNOIiYSKkyRh9LEHaKq_qyg1Yl_ipN4BT2UmjrdJdpfCdbrXBz9V25_AKOulAOd0MeKEbT0GBncbrDtr_wFs89wfNFvCmarc1BAtoHRiv32nj8Mb1xXCOTkpZW7g4zAl6Xd6_LFZBun54XMzTQFFCk0DlPOFlXgDlIiSsVAIYkb6LoqCMR5IBlYliSRGpWFAqeSyjsswjFnFW5pxP0PX-bmf0ew_WZU1lFdS1bEH3NuN0Fs9CERPh0XCPKu-ENVBmnakaaYaMkuwrgMwHkP0NwMuuDh_6vIHiR_TtOP8EkBCB1A</recordid><startdate>20250120</startdate><enddate>20250120</enddate><creator>Kim, Sang-Hoon</creator><creator>Kim, Ki-Hun</creator><creator>Yoon, Young-In</creator><creator>Kang, Woo-Hyoung</creator><creator>Lee, Sang-Kyung</creator><creator>Hwang, Shin</creator><creator>Ahn, Chul-Soo</creator><creator>Moon, Deok-Bog</creator><creator>Ha, Tae-Yong</creator><creator>Song, Gi-Won</creator><creator>Jung, Dong-Hwan</creator><creator>Park, Gil-Chun</creator><creator>Kim, Ji Hoon</creator><creator>Jwa, Eun-Kyoung</creator><creator>Na, Byeong-Gon</creator><creator>Kim, Sung Min</creator><creator>Oh, Rak-Kyun</creator><creator>Jeong, I-Ji</creator><creator>Ko, Hyo Jung</creator><creator>Choi, Minha</creator><creator>Won, Dae Hyeon</creator><creator>Kang, Ji Hoon</creator><creator>Lee, Sung-Gyu</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8025-1816</orcidid><orcidid>https://orcid.org/0000-0002-4016-0995</orcidid></search><sort><creationdate>20250120</creationdate><title>Feasibility of Pure Laparoscopic Donor Right Hepatectomy Compared to Open Donor Right Hepatectomy: A Large Single-Center Cohort Study</title><author>Kim, Sang-Hoon ; Kim, Ki-Hun ; Yoon, Young-In ; Kang, Woo-Hyoung ; Lee, Sang-Kyung ; Hwang, Shin ; Ahn, Chul-Soo ; Moon, Deok-Bog ; Ha, Tae-Yong ; Song, Gi-Won ; Jung, Dong-Hwan ; Park, Gil-Chun ; Kim, Ji Hoon ; Jwa, Eun-Kyoung ; Na, Byeong-Gon ; Kim, Sung Min ; Oh, Rak-Kyun ; Jeong, I-Ji ; Ko, Hyo Jung ; Choi, Minha ; Won, Dae Hyeon ; Kang, Ji Hoon ; Lee, Sung-Gyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1018-cb383fbde139402fc9e20a20addd1236a2e1a8c28d6c7911a37a6ffb62632fb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sang-Hoon</creatorcontrib><creatorcontrib>Kim, Ki-Hun</creatorcontrib><creatorcontrib>Yoon, Young-In</creatorcontrib><creatorcontrib>Kang, Woo-Hyoung</creatorcontrib><creatorcontrib>Lee, Sang-Kyung</creatorcontrib><creatorcontrib>Hwang, Shin</creatorcontrib><creatorcontrib>Ahn, Chul-Soo</creatorcontrib><creatorcontrib>Moon, Deok-Bog</creatorcontrib><creatorcontrib>Ha, Tae-Yong</creatorcontrib><creatorcontrib>Song, Gi-Won</creatorcontrib><creatorcontrib>Jung, Dong-Hwan</creatorcontrib><creatorcontrib>Park, Gil-Chun</creatorcontrib><creatorcontrib>Kim, Ji Hoon</creatorcontrib><creatorcontrib>Jwa, Eun-Kyoung</creatorcontrib><creatorcontrib>Na, Byeong-Gon</creatorcontrib><creatorcontrib>Kim, Sung Min</creatorcontrib><creatorcontrib>Oh, Rak-Kyun</creatorcontrib><creatorcontrib>Jeong, I-Ji</creatorcontrib><creatorcontrib>Ko, Hyo Jung</creatorcontrib><creatorcontrib>Choi, Minha</creatorcontrib><creatorcontrib>Won, Dae Hyeon</creatorcontrib><creatorcontrib>Kang, Ji Hoon</creatorcontrib><creatorcontrib>Lee, Sung-Gyu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sang-Hoon</au><au>Kim, Ki-Hun</au><au>Yoon, Young-In</au><au>Kang, Woo-Hyoung</au><au>Lee, Sang-Kyung</au><au>Hwang, Shin</au><au>Ahn, Chul-Soo</au><au>Moon, Deok-Bog</au><au>Ha, Tae-Yong</au><au>Song, Gi-Won</au><au>Jung, Dong-Hwan</au><au>Park, Gil-Chun</au><au>Kim, Ji Hoon</au><au>Jwa, Eun-Kyoung</au><au>Na, Byeong-Gon</au><au>Kim, Sung Min</au><au>Oh, Rak-Kyun</au><au>Jeong, I-Ji</au><au>Ko, Hyo Jung</au><au>Choi, Minha</au><au>Won, Dae Hyeon</au><au>Kang, Ji Hoon</au><au>Lee, Sung-Gyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility of Pure Laparoscopic Donor Right Hepatectomy Compared to Open Donor Right Hepatectomy: A Large Single-Center Cohort Study</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>2025-01-20</date><risdate>2025</risdate><issn>0003-4932</issn><issn>1528-1140</issn><eissn>1528-1140</eissn><abstract>This study aimed to compare morbidity of living donors and recipients after pure laparoscopic donor right hepatectomy (PLDRH) and open donor right hepatectomy (ODRH).
Donor and recipient morbidity have not been sufficiently reported in large-scale comparisons of PLDRH and ODRH.
This retrospective study reviewed 3348 donors who underwent PLDRH (n=329) and ODRH (n=3019) and their corresponding recipients (n=3348) between January 2014 and August 2023. Donor complications and recipient biliary complications within 90 days were evaluated before and after 1:3 propensity score mathcing (PSM). Multivariate logistic regression analyses identified significant risk factors for donor major and biliary complications, as well as recipient bile leakage and biliary stricture.
For donors, PLDRH had fewer overall complications than ODRH (0.9% vs. 3.7%, P=0.009), with no significant differences in major (Clavien-Dindo III/IV) complications (P=0.057) and biliary complications (P=0.067), despite the absence of biliary complications in PLDRH. However, PLDRH showed longer warm ischemic time and operation time, and higher peak aspartate aminotransferase and alanine aminotransferase levels compared to ODRH in donors (P<0.001). These results remained consistent after PSM. Recipient biliary complications were comparable between PLDRH and ODRH, both before (P=0.806) and after PSM (P=0.149). Multiple portal veins were significant donor risk foctor for major (P=0.022), and biliary complications (P=0.001). Separated multiple bile ducts were common significant recipient risk factor for bile leakage (P=0.007) and biliary stricture (P=0.022).
PLDRH could become the standard for donor right hepatectomy with careful consideration of portal and biliary variations for donor and recipient safety.</abstract><cop>United States</cop><pmid>39829418</pmid><doi>10.1097/SLA.0000000000006633</doi><orcidid>https://orcid.org/0000-0002-8025-1816</orcidid><orcidid>https://orcid.org/0000-0002-4016-0995</orcidid></addata></record> |
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| title | Feasibility of Pure Laparoscopic Donor Right Hepatectomy Compared to Open Donor Right Hepatectomy: A Large Single-Center Cohort Study |
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