Actichinone, a new ursane triterpenoid from Actinidia chinensis roots, ameliorates NAFLD via the AMPK and NF-κB pathways

A new ursane triterpenoid, actichinone (3-oxo-2α,24-dihydroxyurs-12-en-28-oic acid, 1), was isolated from the roots of a kiwi plant Actinidia chinensis Planch, together with 18 known triterpenoids (2–19). The structure of actichinone (1) was established by extensive spectroscopic analysis. Actichino...

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Veröffentlicht in:	European journal of pharmacology 2025-03, Vol.990, p.177276, Article 177276
Hauptverfasser:	Li, Xinhua, Zhang, Yuanlong, Chen, Leiqing, Xu, Xiao, Ma, Xiaohong, Lou, Shuying, Zou, Ziqiang, Wang, Chenjing, Jiang, Bing, Cai, Yunrui, Qi, Yu, Xi, Yiyuan, Zhao, Min, Yan, Pengcheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Actichinone Actinidia - chemistry Actinidia chinensis roots AMP-Activated Protein Kinases - metabolism AMPK Animals Anti-NAFLD effect Diet, High-Fat Hepatocytes - drug effects Hepatocytes - metabolism Lipid Metabolism - drug effects Male Mice Mice, Inbred C57BL NF-kappa B - metabolism NF-κB Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Pentacyclic Triterpenes Plant Roots - chemistry Signal Transduction - drug effects Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Triterpenes - therapeutic use
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