Cardiovascular effects of lactate in healthy adults
Low-volume hypertonic solutions, such as half-molar lactate (LAC), may be a potential treatment used for fluid resuscitation. This study aimed to evaluate the underlying cardiovascular effects and mechanisms of LAC infusion compared to sodium-matched hypertonic sodium chloride (SAL). Eight healthy m...
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| Veröffentlicht in: | Critical care (London, England) England), 2025-01, Vol.29 (1), p.30, Article 30 |
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| creator | Berg-Hansen, Kristoffer Gopalasingam, Nigopan Pedersen, Mette Glavind Bülow Nyvad, Jakob Tobias Rittig, Nikolaj Søndergaard, Esben Wiggers, Henrik Møller, Niels Nielsen, Roni |
| description | Low-volume hypertonic solutions, such as half-molar lactate (LAC), may be a potential treatment used for fluid resuscitation. This study aimed to evaluate the underlying cardiovascular effects and mechanisms of LAC infusion compared to sodium-matched hypertonic sodium chloride (SAL).
Eight healthy male participants were randomized in a controlled, single-blinded, crossover study. Each participant received a four-hour infusion of LAC and SAL in a randomized order. Assessor-blinded echocardiography and blood samples were performed. The primary endpoint was cardiac output (CO) measured by echocardiography.
During LAC infusion, circulating lactate levels increased by 1.9 mmol/L (95% CI 1.8-2.0 mmol/L, P |
| doi_str_mv | 10.1186/s13054-025-05259-0 |
| format | Article |
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Eight healthy male participants were randomized in a controlled, single-blinded, crossover study. Each participant received a four-hour infusion of LAC and SAL in a randomized order. Assessor-blinded echocardiography and blood samples were performed. The primary endpoint was cardiac output (CO) measured by echocardiography.
During LAC infusion, circulating lactate levels increased by 1.9 mmol/L (95% CI 1.8-2.0 mmol/L, P < 0.001) compared with SAL. CO increased by 1.0 L/min (95% CI 0.5-1.4 L/min, P < 0.001), driven primarily by a significant increase in stroke volume of 11 mL (95% CI 4-17 mL, P = 0.002), with no significant change in heart rate. Additionally, left ventricular ejection fraction improved by 5 percentage points (P < 0.001) and global longitudinal strain by 1.5 percentage points (P < 0.001). Preload indicators were elevated during SAL infusion compared with LAC infusion. Concomitantly, afterload parameters, including systemic vascular resistance and effective arterial elastance, were significantly decreased with LAC infusion compared with SAL, while mean arterial pressure remained similar. Indicators of contractility improved during LAC infusion.
In healthy participants, LAC infusion enhanced cardiac function, evidenced by increases in CO, stroke volume, and left ventricular ejection fraction compared with SAL. Indicators of contractility improved, afterload decreased, and preload remained stable. Therefore, LAC infusion may be an advantageous resuscitation fluid, particularly in patients with cardiac dysfunction.
https://clinicaltrials.gov/ct2/show/NCT04710875 . Registered 1 December 2020.</description><identifier>ISSN: 1364-8535</identifier><identifier>ISSN: 1466-609X</identifier><identifier>EISSN: 1466-609X</identifier><identifier>EISSN: 1364-8535</identifier><identifier>DOI: 10.1186/s13054-025-05259-0</identifier><identifier>PMID: 39825426</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Cardiac Output - drug effects ; Cardiac Output - physiology ; Cardiac patients ; Chlorides ; Cross-Over Studies ; Dichloropropane ; Echocardiography - methods ; Healthy Volunteers - statistics & numerical data ; Heart ; Heart beat ; Humans ; Lactic Acid - analysis ; Lactic Acid - blood ; Male ; Single-Blind Method ; Stroke Volume - drug effects ; Stroke Volume - physiology</subject><ispartof>Critical care (London, England), 2025-01, Vol.29 (1), p.30, Article 30</ispartof><rights>2025. The Author(s).</rights><rights>COPYRIGHT 2025 BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2100-b2405b04bf83085e7097f438d528eb661366d0fd2e64136cf60fde1baa9b69313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39825426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berg-Hansen, Kristoffer</creatorcontrib><creatorcontrib>Gopalasingam, Nigopan</creatorcontrib><creatorcontrib>Pedersen, Mette Glavind Bülow</creatorcontrib><creatorcontrib>Nyvad, Jakob Tobias</creatorcontrib><creatorcontrib>Rittig, Nikolaj</creatorcontrib><creatorcontrib>Søndergaard, Esben</creatorcontrib><creatorcontrib>Wiggers, Henrik</creatorcontrib><creatorcontrib>Møller, Niels</creatorcontrib><creatorcontrib>Nielsen, Roni</creatorcontrib><title>Cardiovascular effects of lactate in healthy adults</title><title>Critical care (London, England)</title><addtitle>Crit Care</addtitle><description>Low-volume hypertonic solutions, such as half-molar lactate (LAC), may be a potential treatment used for fluid resuscitation. This study aimed to evaluate the underlying cardiovascular effects and mechanisms of LAC infusion compared to sodium-matched hypertonic sodium chloride (SAL).
Eight healthy male participants were randomized in a controlled, single-blinded, crossover study. Each participant received a four-hour infusion of LAC and SAL in a randomized order. Assessor-blinded echocardiography and blood samples were performed. The primary endpoint was cardiac output (CO) measured by echocardiography.
During LAC infusion, circulating lactate levels increased by 1.9 mmol/L (95% CI 1.8-2.0 mmol/L, P < 0.001) compared with SAL. CO increased by 1.0 L/min (95% CI 0.5-1.4 L/min, P < 0.001), driven primarily by a significant increase in stroke volume of 11 mL (95% CI 4-17 mL, P = 0.002), with no significant change in heart rate. Additionally, left ventricular ejection fraction improved by 5 percentage points (P < 0.001) and global longitudinal strain by 1.5 percentage points (P < 0.001). Preload indicators were elevated during SAL infusion compared with LAC infusion. Concomitantly, afterload parameters, including systemic vascular resistance and effective arterial elastance, were significantly decreased with LAC infusion compared with SAL, while mean arterial pressure remained similar. Indicators of contractility improved during LAC infusion.
In healthy participants, LAC infusion enhanced cardiac function, evidenced by increases in CO, stroke volume, and left ventricular ejection fraction compared with SAL. Indicators of contractility improved, afterload decreased, and preload remained stable. Therefore, LAC infusion may be an advantageous resuscitation fluid, particularly in patients with cardiac dysfunction.
https://clinicaltrials.gov/ct2/show/NCT04710875 . Registered 1 December 2020.</description><subject>Adult</subject><subject>Cardiac Output - drug effects</subject><subject>Cardiac Output - physiology</subject><subject>Cardiac patients</subject><subject>Chlorides</subject><subject>Cross-Over Studies</subject><subject>Dichloropropane</subject><subject>Echocardiography - methods</subject><subject>Healthy Volunteers - statistics & numerical data</subject><subject>Heart</subject><subject>Heart beat</subject><subject>Humans</subject><subject>Lactic Acid - analysis</subject><subject>Lactic Acid - blood</subject><subject>Male</subject><subject>Single-Blind Method</subject><subject>Stroke Volume - drug effects</subject><subject>Stroke Volume - physiology</subject><issn>1364-8535</issn><issn>1466-609X</issn><issn>1466-609X</issn><issn>1364-8535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU9LxDAQxYMo7rr6BTxIwYuXrJOkyabHZfEfLHhR8BbSdOJWuu3atMJ-e1OrgiBzmMnwe8Mjj5BzBnPGtLoOTIBMKXBJQXKZUTggU5YqRRVkL4dxFiqlWgo5ISchvAGwhVbimExEprlMuZoSsbJtUTYfNri-sm2C3qPrQtL4pLKusx0mZZ1s0FbdZp_Yoq-6cEqOvK0Cnn33GXm-vXla3dP1493DarmmjjMAmvMUZA5p7rUALXEB2cKnQheSa8yViu5UAb7gqNI4O6_iA1lubZarTDAxI1fj3V3bvPcYOrMtg8OqsjU2fTCCSZUNNaCXI_pqKzRl7ZuutW7AzVJHHywDCZGa_0PFKnBbuqZGX8b9HwEfBa5tQmjRm11bbm27NwzMkIEZMzAxA_OVgRlEF9-2-3yLxa_k59PFJ3z5fqE</recordid><startdate>20250117</startdate><enddate>20250117</enddate><creator>Berg-Hansen, Kristoffer</creator><creator>Gopalasingam, Nigopan</creator><creator>Pedersen, Mette Glavind Bülow</creator><creator>Nyvad, Jakob Tobias</creator><creator>Rittig, Nikolaj</creator><creator>Søndergaard, Esben</creator><creator>Wiggers, Henrik</creator><creator>Møller, Niels</creator><creator>Nielsen, Roni</creator><general>BioMed Central Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20250117</creationdate><title>Cardiovascular effects of lactate in healthy adults</title><author>Berg-Hansen, Kristoffer ; Gopalasingam, Nigopan ; Pedersen, Mette Glavind Bülow ; Nyvad, Jakob Tobias ; Rittig, Nikolaj ; Søndergaard, Esben ; Wiggers, Henrik ; Møller, Niels ; Nielsen, Roni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2100-b2405b04bf83085e7097f438d528eb661366d0fd2e64136cf60fde1baa9b69313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Cardiac Output - drug effects</topic><topic>Cardiac Output - physiology</topic><topic>Cardiac patients</topic><topic>Chlorides</topic><topic>Cross-Over Studies</topic><topic>Dichloropropane</topic><topic>Echocardiography - methods</topic><topic>Healthy Volunteers - statistics & numerical data</topic><topic>Heart</topic><topic>Heart beat</topic><topic>Humans</topic><topic>Lactic Acid - analysis</topic><topic>Lactic Acid - blood</topic><topic>Male</topic><topic>Single-Blind Method</topic><topic>Stroke Volume - drug effects</topic><topic>Stroke Volume - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berg-Hansen, Kristoffer</creatorcontrib><creatorcontrib>Gopalasingam, Nigopan</creatorcontrib><creatorcontrib>Pedersen, Mette Glavind Bülow</creatorcontrib><creatorcontrib>Nyvad, Jakob Tobias</creatorcontrib><creatorcontrib>Rittig, Nikolaj</creatorcontrib><creatorcontrib>Søndergaard, Esben</creatorcontrib><creatorcontrib>Wiggers, Henrik</creatorcontrib><creatorcontrib>Møller, Niels</creatorcontrib><creatorcontrib>Nielsen, Roni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berg-Hansen, Kristoffer</au><au>Gopalasingam, Nigopan</au><au>Pedersen, Mette Glavind Bülow</au><au>Nyvad, Jakob Tobias</au><au>Rittig, Nikolaj</au><au>Søndergaard, Esben</au><au>Wiggers, Henrik</au><au>Møller, Niels</au><au>Nielsen, Roni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular effects of lactate in healthy adults</atitle><jtitle>Critical care (London, England)</jtitle><addtitle>Crit Care</addtitle><date>2025-01-17</date><risdate>2025</risdate><volume>29</volume><issue>1</issue><spage>30</spage><pages>30-</pages><artnum>30</artnum><issn>1364-8535</issn><issn>1466-609X</issn><eissn>1466-609X</eissn><eissn>1364-8535</eissn><abstract>Low-volume hypertonic solutions, such as half-molar lactate (LAC), may be a potential treatment used for fluid resuscitation. This study aimed to evaluate the underlying cardiovascular effects and mechanisms of LAC infusion compared to sodium-matched hypertonic sodium chloride (SAL).
Eight healthy male participants were randomized in a controlled, single-blinded, crossover study. Each participant received a four-hour infusion of LAC and SAL in a randomized order. Assessor-blinded echocardiography and blood samples were performed. The primary endpoint was cardiac output (CO) measured by echocardiography.
During LAC infusion, circulating lactate levels increased by 1.9 mmol/L (95% CI 1.8-2.0 mmol/L, P < 0.001) compared with SAL. CO increased by 1.0 L/min (95% CI 0.5-1.4 L/min, P < 0.001), driven primarily by a significant increase in stroke volume of 11 mL (95% CI 4-17 mL, P = 0.002), with no significant change in heart rate. Additionally, left ventricular ejection fraction improved by 5 percentage points (P < 0.001) and global longitudinal strain by 1.5 percentage points (P < 0.001). Preload indicators were elevated during SAL infusion compared with LAC infusion. Concomitantly, afterload parameters, including systemic vascular resistance and effective arterial elastance, were significantly decreased with LAC infusion compared with SAL, while mean arterial pressure remained similar. Indicators of contractility improved during LAC infusion.
In healthy participants, LAC infusion enhanced cardiac function, evidenced by increases in CO, stroke volume, and left ventricular ejection fraction compared with SAL. Indicators of contractility improved, afterload decreased, and preload remained stable. Therefore, LAC infusion may be an advantageous resuscitation fluid, particularly in patients with cardiac dysfunction.
https://clinicaltrials.gov/ct2/show/NCT04710875 . Registered 1 December 2020.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39825426</pmid><doi>10.1186/s13054-025-05259-0</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA Free Journals |
| subjects | Adult Cardiac Output - drug effects Cardiac Output - physiology Cardiac patients Chlorides Cross-Over Studies Dichloropropane Echocardiography - methods Healthy Volunteers - statistics & numerical data Heart Heart beat Humans Lactic Acid - analysis Lactic Acid - blood Male Single-Blind Method Stroke Volume - drug effects Stroke Volume - physiology |
| title | Cardiovascular effects of lactate in healthy adults |
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