Development and validation of a UPLC–MS/MS method for simultaneous quantification of polymyxins and caspofungin in human plasma for therapeutic drug monitoring

•An UPLC–MS/MS method for the simultaneous quantification of polymyxin (B or E) and caspofungin in human plasma.•This is the first report where the peptide substance bacitracin zinc was used as an internal standard.•This method is characterized by its rapid, convenient, accurate, and low-residual-ef...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2025-02, Vol.1252, p.124465, Article 124465
Hauptverfasser:	Wu, Tong, Pu, Libin, Liu, Wenqing, Bai, Yinliang, Ma, Jingjing, Song, Xia, Cao, Aijia, Pan, Shunli, Yang, Jiahui, Wang, Chang, Qiu, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Caspofungin acetate Colistin sulfate Polymyxin B sulfate Therapeutic drug monitoring UPLC–MS/MS
Online-Zugang:	Volltext
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