Three Novel Quinoline Alkaloids From Tetradium glabrifolium and Their Antibacterial Activities
Three novel quinoline alkaloids, tetradiunitiside A (1), tetradiunitiside B (2), and glycohaplopine-6-O-α-l-rhamnopyranoside (3), along with eight known ones (4-11), were isolated from the fruits of Tetradium glabrifolium. Their structures were inferred by IR, 1D NMR and 2D NMR, and HR-ESI-MS spectr...
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| creator | Luo, Li-Li Chen, Jun-Lei Du, Cai-Xia Huang, Lie-Jun Yuan, Chun-Mao Yang, Jue Hu, Zhan-Xing Hao, Xiao-Jiang Gu, Wei |
| description | Three novel quinoline alkaloids, tetradiunitiside A (1), tetradiunitiside B (2), and glycohaplopine-6-O-α-l-rhamnopyranoside (3), along with eight known ones (4-11), were isolated from the fruits of Tetradium glabrifolium. Their structures were inferred by IR, 1D NMR and 2D NMR, and HR-ESI-MS spectra. All the isolated compounds were evaluated for their antibacterial activities. Compounds 1-11 had potential antibacterial activities against Bacillus gasoformans, Bacillus subtilis, Pseudomonas solanacearum, and Pseudomonas aeruginosa, with minimum inhibitory concentration (MIC) values ranging from 100 to 3.125 µg/mL. Among them, compound 6 showed the most significant antibacterial activity against four strains of bacteria. These findings elucidated the pharmacological substance basis for the antibacterial activity of T. glabrifolium to some extent. |
| doi_str_mv | 10.1002/cbdv.202402980 |
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| title | Three Novel Quinoline Alkaloids From Tetradium glabrifolium and Their Antibacterial Activities |
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