Effects of blood pressure lowering in patients treated with intravenous thrombolysis before endovascular thrombectomy

The effects of blood pressure (BP) lowering in patients treated with intravenous tissue plasminogen activator (IV tPA) before endovascular thrombectomy (EVT) are unclear. This study aims to investigate whether intensive and conventional BP management affects outcomes differently, depending on IV tPA administration before EVT. In this subgroup analysis of the Outcome in Patients Treated with Intra-Arterial Thrombectomy-Optimal Blood Pressure Control (OPTIMAL-BP; ClinicalTrials.gov Identifier: NCT04205305) trial, patients were divided into groups based on IV tPA use before EVT. Clinical outcomes of intensive (systolic BP target