Merged Red and NIR Light Sources for Photobiomodulation Therapy in Diabetic Wound Healing
Photobiomodulation (PBM) is considered an effective and safe therapeutic modality in supporting the treatment of complications from a global pandemic-diabetes. In this study, PBM therapy is investigated to accelerate wound healing in diabetic mice (DM), under the combined biological effects of red l...
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| Veröffentlicht in: | ACS applied materials & interfaces 2025-01, Vol.17 (4), p.5771-5783 |
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| container_title | ACS applied materials & interfaces |
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| creator | Thien Tri, Tran Nam, Nguyen Dang Lee, Tae Hyeong Shin, Haksup Lee, Hyun Jong Chae, Heeyeop Kim, Min Ji Jo, Deok Su Cho, Sung Min |
| description | Photobiomodulation (PBM) is considered an effective and safe therapeutic modality in supporting the treatment of complications from a global pandemic-diabetes. In this study, PBM therapy is investigated to accelerate wound healing in diabetic mice (DM), under the combined biological effects of red light from a red organic light-emitting diode (ROLED) and near-infrared (NIR) light from an NIR conversion film (NCF) with dispersed CuInS2/ZnS quantum dots (QDs). The QD concentration and the NCF structure were optimized to maximize the optical properties and mechanical stability. A merged red/NIR device (MRND) was produced by integrating the optimized NCF and ROLED for PBM therapy. As a result of irradiating DM with MRND at a dose of 2 J/cm2, after 10 days, the wounds recovered three times faster than DM without MRND. Additionally, MRND light not only restored the epidermal thickness to normal but also significantly reduced the levels of pro-inflammatory cytokines. The experimental results show that the proposed PBM therapy has the potential to improve the quality of life of diabetic patients by helping them with rapid wound healing. |
| doi_str_mv | 10.1021/acsami.4c16914 |
| format | Article |
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In this study, PBM therapy is investigated to accelerate wound healing in diabetic mice (DM), under the combined biological effects of red light from a red organic light-emitting diode (ROLED) and near-infrared (NIR) light from an NIR conversion film (NCF) with dispersed CuInS2/ZnS quantum dots (QDs). The QD concentration and the NCF structure were optimized to maximize the optical properties and mechanical stability. A merged red/NIR device (MRND) was produced by integrating the optimized NCF and ROLED for PBM therapy. As a result of irradiating DM with MRND at a dose of 2 J/cm2, after 10 days, the wounds recovered three times faster than DM without MRND. Additionally, MRND light not only restored the epidermal thickness to normal but also significantly reduced the levels of pro-inflammatory cytokines. The experimental results show that the proposed PBM therapy has the potential to improve the quality of life of diabetic patients by helping them with rapid wound healing.</description><identifier>ISSN: 1944-8244</identifier><identifier>ISSN: 1944-8252</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.4c16914</identifier><identifier>PMID: 39818728</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Biological and Medical Applications of Materials and Interfaces ; Diabetes Mellitus, Experimental ; Infrared Rays - therapeutic use ; Low-Level Light Therapy - methods ; Male ; Mice ; Quantum Dots - chemistry ; Quantum Dots - therapeutic use ; Wound Healing - drug effects ; Wound Healing - radiation effects ; Zinc Compounds - chemistry ; Zinc Compounds - therapeutic use</subject><ispartof>ACS applied materials & interfaces, 2025-01, Vol.17 (4), p.5771-5783</ispartof><rights>2025 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a215t-6ad4aacc91234737fd1fd8a16f5335cdbf94994d3f1acd49ddac7a34db97726e3</cites><orcidid>0009-0009-7587-6473 ; 0000-0001-5858-9725 ; 0009-0002-8811-6026 ; 0000-0002-6380-0414 ; 0000-0002-6443-0902</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.4c16914$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.4c16914$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39818728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thien Tri, Tran</creatorcontrib><creatorcontrib>Nam, Nguyen Dang</creatorcontrib><creatorcontrib>Lee, Tae Hyeong</creatorcontrib><creatorcontrib>Shin, Haksup</creatorcontrib><creatorcontrib>Lee, Hyun Jong</creatorcontrib><creatorcontrib>Chae, Heeyeop</creatorcontrib><creatorcontrib>Kim, Min Ji</creatorcontrib><creatorcontrib>Jo, Deok Su</creatorcontrib><creatorcontrib>Cho, Sung Min</creatorcontrib><title>Merged Red and NIR Light Sources for Photobiomodulation Therapy in Diabetic Wound Healing</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. Mater. Interfaces</addtitle><description>Photobiomodulation (PBM) is considered an effective and safe therapeutic modality in supporting the treatment of complications from a global pandemic-diabetes. In this study, PBM therapy is investigated to accelerate wound healing in diabetic mice (DM), under the combined biological effects of red light from a red organic light-emitting diode (ROLED) and near-infrared (NIR) light from an NIR conversion film (NCF) with dispersed CuInS2/ZnS quantum dots (QDs). The QD concentration and the NCF structure were optimized to maximize the optical properties and mechanical stability. A merged red/NIR device (MRND) was produced by integrating the optimized NCF and ROLED for PBM therapy. As a result of irradiating DM with MRND at a dose of 2 J/cm2, after 10 days, the wounds recovered three times faster than DM without MRND. Additionally, MRND light not only restored the epidermal thickness to normal but also significantly reduced the levels of pro-inflammatory cytokines. The experimental results show that the proposed PBM therapy has the potential to improve the quality of life of diabetic patients by helping them with rapid wound healing.</description><subject>Animals</subject><subject>Biological and Medical Applications of Materials and Interfaces</subject><subject>Diabetes Mellitus, Experimental</subject><subject>Infrared Rays - therapeutic use</subject><subject>Low-Level Light Therapy - methods</subject><subject>Male</subject><subject>Mice</subject><subject>Quantum Dots - chemistry</subject><subject>Quantum Dots - therapeutic use</subject><subject>Wound Healing - drug effects</subject><subject>Wound Healing - radiation effects</subject><subject>Zinc Compounds - chemistry</subject><subject>Zinc Compounds - therapeutic use</subject><issn>1944-8244</issn><issn>1944-8252</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kElPwzAQRi0EoqVw5Yh8REgp8ZLFR1SWViqLShHiFE1sp3WVxMVODv33BKX0xmE0c3jfJ81D6JKEYxJScgvSQ2XGXJJYEH6EhkRwHqQ0oseHm_MBOvN-E4Yxo2F0igZMpCRNaDpEX8_arbTCi26gVvhltsBzs1o3-N22TmqPC-vw29o2Nje2sqotoTG2xsu1drDdYVPjewO5bozEn7btKqYaSlOvztFJAaXXF_s9Qh-PD8vJNJi_Ps0md_MAKImaIAbFAaQUhDKesKRQpFApkLiIGIukygvBheCKFQSk4kIpkAkwrnKRJDTWbISu-96ts9-t9k1WGS91WUKtbeszRqI44mFIow4d96h01nuni2zrTAVul5Ew-9WZ9Tqzvc4ucLXvbvNKqwP-568DbnqgC2abzljdvfpf2w9OO4AD</recordid><startdate>20250129</startdate><enddate>20250129</enddate><creator>Thien Tri, Tran</creator><creator>Nam, Nguyen Dang</creator><creator>Lee, Tae Hyeong</creator><creator>Shin, Haksup</creator><creator>Lee, Hyun Jong</creator><creator>Chae, Heeyeop</creator><creator>Kim, Min Ji</creator><creator>Jo, Deok Su</creator><creator>Cho, Sung Min</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0009-7587-6473</orcidid><orcidid>https://orcid.org/0000-0001-5858-9725</orcidid><orcidid>https://orcid.org/0009-0002-8811-6026</orcidid><orcidid>https://orcid.org/0000-0002-6380-0414</orcidid><orcidid>https://orcid.org/0000-0002-6443-0902</orcidid></search><sort><creationdate>20250129</creationdate><title>Merged Red and NIR Light Sources for Photobiomodulation Therapy in Diabetic Wound Healing</title><author>Thien Tri, Tran ; Nam, Nguyen Dang ; Lee, Tae Hyeong ; Shin, Haksup ; Lee, Hyun Jong ; Chae, Heeyeop ; Kim, Min Ji ; Jo, Deok Su ; Cho, Sung Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a215t-6ad4aacc91234737fd1fd8a16f5335cdbf94994d3f1acd49ddac7a34db97726e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Animals</topic><topic>Biological and Medical Applications of Materials and Interfaces</topic><topic>Diabetes Mellitus, Experimental</topic><topic>Infrared Rays - therapeutic use</topic><topic>Low-Level Light Therapy - methods</topic><topic>Male</topic><topic>Mice</topic><topic>Quantum Dots - chemistry</topic><topic>Quantum Dots - therapeutic use</topic><topic>Wound Healing - drug effects</topic><topic>Wound Healing - radiation effects</topic><topic>Zinc Compounds - chemistry</topic><topic>Zinc Compounds - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thien Tri, Tran</creatorcontrib><creatorcontrib>Nam, Nguyen Dang</creatorcontrib><creatorcontrib>Lee, Tae Hyeong</creatorcontrib><creatorcontrib>Shin, Haksup</creatorcontrib><creatorcontrib>Lee, Hyun Jong</creatorcontrib><creatorcontrib>Chae, Heeyeop</creatorcontrib><creatorcontrib>Kim, Min Ji</creatorcontrib><creatorcontrib>Jo, Deok Su</creatorcontrib><creatorcontrib>Cho, Sung Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thien Tri, Tran</au><au>Nam, Nguyen Dang</au><au>Lee, Tae Hyeong</au><au>Shin, Haksup</au><au>Lee, Hyun Jong</au><au>Chae, Heeyeop</au><au>Kim, Min Ji</au><au>Jo, Deok Su</au><au>Cho, Sung Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Merged Red and NIR Light Sources for Photobiomodulation Therapy in Diabetic Wound Healing</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. 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As a result of irradiating DM with MRND at a dose of 2 J/cm2, after 10 days, the wounds recovered three times faster than DM without MRND. Additionally, MRND light not only restored the epidermal thickness to normal but also significantly reduced the levels of pro-inflammatory cytokines. The experimental results show that the proposed PBM therapy has the potential to improve the quality of life of diabetic patients by helping them with rapid wound healing.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>39818728</pmid><doi>10.1021/acsami.4c16914</doi><tpages>13</tpages><orcidid>https://orcid.org/0009-0009-7587-6473</orcidid><orcidid>https://orcid.org/0000-0001-5858-9725</orcidid><orcidid>https://orcid.org/0009-0002-8811-6026</orcidid><orcidid>https://orcid.org/0000-0002-6380-0414</orcidid><orcidid>https://orcid.org/0000-0002-6443-0902</orcidid></addata></record> |
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| subjects | Animals Biological and Medical Applications of Materials and Interfaces Diabetes Mellitus, Experimental Infrared Rays - therapeutic use Low-Level Light Therapy - methods Male Mice Quantum Dots - chemistry Quantum Dots - therapeutic use Wound Healing - drug effects Wound Healing - radiation effects Zinc Compounds - chemistry Zinc Compounds - therapeutic use |
| title | Merged Red and NIR Light Sources for Photobiomodulation Therapy in Diabetic Wound Healing |
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