Optimal chemokine receptors for enhancing immune cell trafficking in adoptive cell therapy

Recently, a strategy involving the engineering of chemokine receptors on immune cells was developed to optimize adoptive cell therapy (ACT) for solid tumors. Given the variability in chemokine secretion among different tumor types, identifying and modulating the appropriate chemokine receptors is cr...

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Veröffentlicht in:	Immunologic research 2025-12, Vol.73 (1), p.36, Article 36
Hauptverfasser:	Han, DoYeon, Jeong, Byung-Kwan, Hong, Jong Moo, Seo, Jeong-Han, Lee, GunHee, Kim, Kwanghee, Hong, Chorong, Lee, Hyeonjin, Cha, Su Min, Kim, Jong Hyeok, Park, Taehyun, Gong, Gyungyub, Lee, Hee Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Biomedical and Life Sciences Biomedicine Cancer therapies CC chemokine receptors Cell Line, Tumor Cell Movement Cell therapy Cell viability Chemokine receptors Chemokines Chimeric antigen receptors CXCR5 protein Cytotoxicity Genomic analysis Genotypes Humans Immunology Immunotherapy, Adoptive - methods Internal Medicine Leukocyte migration Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Medicine/Public Health Neoplasms - immunology Neoplasms - therapy Receptors, Chemokine - metabolism Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - immunology Receptors, Chimeric Antigen - metabolism Receptors, CXCR5 - metabolism Solid tumors Tumor-infiltrating lymphocytes
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