Integrated ecological-health risk assessment of ofloxacin
Antibiotics are emerging contaminants of significant concern, while previous research has mostly focused on their ecological or health impacts in isolation. This limited systematic research on its overall risk and the uncertainty relating to the risk evaluation is also unclear. This study addressed...
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Veröffentlicht in: | Journal of hazardous materials 2025-01, Vol.487, p.137178, Article 137178 |
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container_title | Journal of hazardous materials |
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creator | Wang, Jingyu Ma, Yukun Zhou, Xuehui Wang, Shuai Fu, Yijia Gao, Shenghan Meng, Xinyi Shen, Zhenyao Chen, Lei |
description | Antibiotics are emerging contaminants of significant concern, while previous research has mostly focused on their ecological or health impacts in isolation. This limited systematic research on its overall risk and the uncertainty relating to the risk evaluation is also unclear. This study addressed this gap by examining both ecological or health impacts by integrating interspecies correlation models, species sensitivity distribution curves, and health risk evaluation. Then comprehensive risk of antibiotics was calculated using economic approaches. The Wenyu River basin in China and ofloxacin were chosen as the study area and target antibiotic, respectively. The results indicate that both the ecological and health risk quotients for ofloxacin were manageable, and the level of urbanization was found to correlate with increased antibiotic risk. The economic impact on population health was greater than on ecosystems. The presence of ofloxacin in the watershed still resulted in more than $200,000 in annual economic losses, affecting both human society and the ecosystem. The assessment process, including the evaluation object, extrapolated data, and fitted curves, contributed to uncertainty in the results. These findings provide valuable insights for addressing the challenges in assessing the risks of antibiotics, emphasizing the need for integrated assessment frameworks.
[Display omitted]
•Both ecological and health risks of ofloxacin were evaluated in an urban watershed;•Integrated risk of ofloxacin were calculated using economic approaches;•The uncertainty relating to risk evaluation of antibiotics was analyzed;•The presence of ofloxacin resulted in more than $200,000 in annual economic losses;•The evaluation object, extrapolated data, and fitting curves cause uncertainty. |
doi_str_mv | 10.1016/j.jhazmat.2025.137178 |
format | Article |
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[Display omitted]
•Both ecological and health risks of ofloxacin were evaluated in an urban watershed;•Integrated risk of ofloxacin were calculated using economic approaches;•The uncertainty relating to risk evaluation of antibiotics was analyzed;•The presence of ofloxacin resulted in more than $200,000 in annual economic losses;•The evaluation object, extrapolated data, and fitting curves cause uncertainty.</description><identifier>ISSN: 0304-3894</identifier><identifier>ISSN: 1873-3336</identifier><identifier>EISSN: 1873-3336</identifier><identifier>DOI: 10.1016/j.jhazmat.2025.137178</identifier><identifier>PMID: 39808966</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Ecological risk ; Health risk ; Ofloxacin ; Uncertainty ; Urbanization</subject><ispartof>Journal of hazardous materials, 2025-01, Vol.487, p.137178, Article 137178</ispartof><rights>2025 Elsevier B.V.</rights><rights>Copyright © 2025 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1586-e7cd65f138aa0b75e6c28a5d506e52532b4f450cfe026b4ffccd73d8a15be5ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304389425000901$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39808966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jingyu</creatorcontrib><creatorcontrib>Ma, Yukun</creatorcontrib><creatorcontrib>Zhou, Xuehui</creatorcontrib><creatorcontrib>Wang, Shuai</creatorcontrib><creatorcontrib>Fu, Yijia</creatorcontrib><creatorcontrib>Gao, Shenghan</creatorcontrib><creatorcontrib>Meng, Xinyi</creatorcontrib><creatorcontrib>Shen, Zhenyao</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><title>Integrated ecological-health risk assessment of ofloxacin</title><title>Journal of hazardous materials</title><addtitle>J Hazard Mater</addtitle><description>Antibiotics are emerging contaminants of significant concern, while previous research has mostly focused on their ecological or health impacts in isolation. This limited systematic research on its overall risk and the uncertainty relating to the risk evaluation is also unclear. This study addressed this gap by examining both ecological or health impacts by integrating interspecies correlation models, species sensitivity distribution curves, and health risk evaluation. Then comprehensive risk of antibiotics was calculated using economic approaches. The Wenyu River basin in China and ofloxacin were chosen as the study area and target antibiotic, respectively. The results indicate that both the ecological and health risk quotients for ofloxacin were manageable, and the level of urbanization was found to correlate with increased antibiotic risk. The economic impact on population health was greater than on ecosystems. The presence of ofloxacin in the watershed still resulted in more than $200,000 in annual economic losses, affecting both human society and the ecosystem. The assessment process, including the evaluation object, extrapolated data, and fitted curves, contributed to uncertainty in the results. These findings provide valuable insights for addressing the challenges in assessing the risks of antibiotics, emphasizing the need for integrated assessment frameworks.
[Display omitted]
•Both ecological and health risks of ofloxacin were evaluated in an urban watershed;•Integrated risk of ofloxacin were calculated using economic approaches;•The uncertainty relating to risk evaluation of antibiotics was analyzed;•The presence of ofloxacin resulted in more than $200,000 in annual economic losses;•The evaluation object, extrapolated data, and fitting curves cause uncertainty.</description><subject>Ecological risk</subject><subject>Health risk</subject><subject>Ofloxacin</subject><subject>Uncertainty</subject><subject>Urbanization</subject><issn>0304-3894</issn><issn>1873-3336</issn><issn>1873-3336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOwzAQRS0EoqXwCaAu2STYcfzICqGKR6VKbGBtOfakdUjiYqcI-HpSpbBFGmlmce6M5iB0SXBKMOE3dVpv9Her-zTDGUsJFUTIIzQlUtCEUsqP0RRTnCdUFvkEncVYY4yJYPkpmtBCYllwPkXFsuthHXQPdg7GN37tjG6SDeim38yDi29zHSPE2ELXz301VOM_tXHdOTqpdBPh4tBn6PXh_mXxlKyeH5eLu1ViCJM8AWEsZxWhUmtcCgbcZFIzyzAHljGalXmVM2wqwBkf5soYK6iVmrASmAE6Q9fj3m3w7zuIvWpdNNA0ugO_i4oSxkSGKRcDykbUBB9jgEptg2t1-FIEq701VauDNbW3pkZrQ-7qcGJXtmD_Ur-aBuB2BGB49MNBUNE46AxYF8D0ynr3z4kfiFiBAg</recordid><startdate>20250110</startdate><enddate>20250110</enddate><creator>Wang, Jingyu</creator><creator>Ma, Yukun</creator><creator>Zhou, Xuehui</creator><creator>Wang, Shuai</creator><creator>Fu, Yijia</creator><creator>Gao, Shenghan</creator><creator>Meng, Xinyi</creator><creator>Shen, Zhenyao</creator><creator>Chen, Lei</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20250110</creationdate><title>Integrated ecological-health risk assessment of ofloxacin</title><author>Wang, Jingyu ; Ma, Yukun ; Zhou, Xuehui ; Wang, Shuai ; Fu, Yijia ; Gao, Shenghan ; Meng, Xinyi ; Shen, Zhenyao ; Chen, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1586-e7cd65f138aa0b75e6c28a5d506e52532b4f450cfe026b4ffccd73d8a15be5ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Ecological risk</topic><topic>Health risk</topic><topic>Ofloxacin</topic><topic>Uncertainty</topic><topic>Urbanization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jingyu</creatorcontrib><creatorcontrib>Ma, Yukun</creatorcontrib><creatorcontrib>Zhou, Xuehui</creatorcontrib><creatorcontrib>Wang, Shuai</creatorcontrib><creatorcontrib>Fu, Yijia</creatorcontrib><creatorcontrib>Gao, Shenghan</creatorcontrib><creatorcontrib>Meng, Xinyi</creatorcontrib><creatorcontrib>Shen, Zhenyao</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hazardous materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jingyu</au><au>Ma, Yukun</au><au>Zhou, Xuehui</au><au>Wang, Shuai</au><au>Fu, Yijia</au><au>Gao, Shenghan</au><au>Meng, Xinyi</au><au>Shen, Zhenyao</au><au>Chen, Lei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integrated ecological-health risk assessment of ofloxacin</atitle><jtitle>Journal of hazardous materials</jtitle><addtitle>J Hazard Mater</addtitle><date>2025-01-10</date><risdate>2025</risdate><volume>487</volume><spage>137178</spage><pages>137178-</pages><artnum>137178</artnum><issn>0304-3894</issn><issn>1873-3336</issn><eissn>1873-3336</eissn><abstract>Antibiotics are emerging contaminants of significant concern, while previous research has mostly focused on their ecological or health impacts in isolation. This limited systematic research on its overall risk and the uncertainty relating to the risk evaluation is also unclear. This study addressed this gap by examining both ecological or health impacts by integrating interspecies correlation models, species sensitivity distribution curves, and health risk evaluation. Then comprehensive risk of antibiotics was calculated using economic approaches. The Wenyu River basin in China and ofloxacin were chosen as the study area and target antibiotic, respectively. The results indicate that both the ecological and health risk quotients for ofloxacin were manageable, and the level of urbanization was found to correlate with increased antibiotic risk. The economic impact on population health was greater than on ecosystems. The presence of ofloxacin in the watershed still resulted in more than $200,000 in annual economic losses, affecting both human society and the ecosystem. The assessment process, including the evaluation object, extrapolated data, and fitted curves, contributed to uncertainty in the results. These findings provide valuable insights for addressing the challenges in assessing the risks of antibiotics, emphasizing the need for integrated assessment frameworks.
[Display omitted]
•Both ecological and health risks of ofloxacin were evaluated in an urban watershed;•Integrated risk of ofloxacin were calculated using economic approaches;•The uncertainty relating to risk evaluation of antibiotics was analyzed;•The presence of ofloxacin resulted in more than $200,000 in annual economic losses;•The evaluation object, extrapolated data, and fitting curves cause uncertainty.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39808966</pmid><doi>10.1016/j.jhazmat.2025.137178</doi></addata></record> |
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subjects | Ecological risk Health risk Ofloxacin Uncertainty Urbanization |
title | Integrated ecological-health risk assessment of ofloxacin |
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