Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4'-Fluorouridine

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that has re-emerged to cause large outbreaks of human infections worldwide. There are currently no approved antivirals for treatment of CHIKV infection. Recently, we reported that the ribonucleoside analog 4'-fluorouridine (4'-FlU) i...

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Veröffentlicht in:	PLoS pathogens 2025-01, Vol.21 (1), p.e1012859
Hauptverfasser:	Yin, Peiqi, Sobolik, Elizabeth B, May, Nicholas A, Wang, Sainan, Fayed, Atef, Vyshenska, Dariia, Drobish, Adam M, Parks, M Guston, Lello, Laura Sandra, Merits, Andres, Morrison, Thomas E, Greninger, Alexander L, Kielian, Margaret
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Chikungunya Fever - drug therapy Chikungunya Fever - virology Chikungunya virus - drug effects Chikungunya virus - genetics Genetic Fitness Humans Mice Mutation Uridine - analogs & derivatives Uridine - pharmacology Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virus Replication - drug effects
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