Stage-specific expression and divergent functions of two insulinase-like proteases associated with host infectivity in Cryptosporidium

The determinants of differences in host infectivity among Cryptosporidium species and subtypes are poorly understood. Results from recent comparative genomic studies suggest that gains and losses of multicopy subtelomeric genes encoding insulinase-like proteases (INS-19 and INS-20 in Cryptosporidium...

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Veröffentlicht in:	PLoS neglected tropical diseases 2025-01, Vol.19 (1), p.e0012777
Hauptverfasser:	Huang, Yue, Pei, Shifeng, Lv, Xin, Yang, Fuxian, Gong, Xiaoqing, Li, Na, Guo, Yaqiong, Feng, Yaoyu, Xiao, Lihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences CRISPR-Cas Systems Cryptosporidiosis - parasitology Cryptosporidium parvum - enzymology Cryptosporidium parvum - genetics Cryptosporidium parvum - pathogenicity Engineering and Technology Humans Insulysin - genetics Insulysin - metabolism Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Protozoan Proteins - genetics Protozoan Proteins - metabolism Research and Analysis Methods
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