Triple-Negative Breast Cancer Aptamer-Targeting Porous Silicon Nanocarrier

Common treatment approaches for triple-negative breast cancer (TNBC) are associated with severe side effects due to the unfavorable biodistribution profile of potent chemotherapeutics. Here, we explored the potential of TNBC-targeting aptamer-decorated porous silicon nanoparticles (pSiNPs) as target...

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Veröffentlicht in:	ACS applied materials & interfaces 2025-01, Vol.17 (4), p.5955-5969
Hauptverfasser:	Malhotra, Ankit, Dehghankelishadi, Pouya, Kaur, Ishdeep, Marshall, Morgan, Rudd, David, Wojnilowicz, Marcin, Nowell, Cameron J., Fulcher, Alex J., Esser, Lars, Tong, Wing Yin, Cifuentes, Anna, Wagstaff, Kylie M., Voelcker, Nicolas H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aptamers, Nucleotide - chemistry Biological and Medical Applications of Materials and Interfaces Cell Line, Tumor Cell Survival - drug effects Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemistry Female Humans Lysosomes - metabolism Mice Nanoparticles - chemistry Porosity Silicon - chemistry Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology
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