Drug-linker constructs bearing unique dual-mechanism tubulin binding payloads tethered through cleavable and non-cleavable linkers

Antibody-drug conjugates (ADCs) have advanced as a mainstay among the most promising cancer therapeutics, offering enhanced antigen targeting and encompassing wide diversity in their linker and payload components. Small-molecule inhibitors of tubulin polymerization have found success as payloads in...

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Veröffentlicht in:	Tetrahedron 2025-02, Vol.171, p.134350, Article 134350
Hauptverfasser:	Ford, Jacob W., VanNatta, Jennifer M., Mondal, Deboprosad, Lin, Chen-Ming, Deng, Yuling, Bai, Ruoli, Hamel, Ernest, Trawick, Mary Lynn, Pinney, Kevin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cathepsin B cleavable linkers Dual mechanism payloads Inhibitors of tubulin polymerization Non-cleavable linkers Synthesis of drug-linker constructs Vascular disrupting agents
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