DESCRIPTION OF THE CLINICAL AND RADIOLOGICAL CHARACTERISTICS OF PULMONARY EMBOLISM IN COVID-19 VERSUS NON COVID-19 PATIENTS: A MULTICENTRIC CROSS-SECTIONAL STUDY OVER A 24-MONTH PERSPECTIVE
COVID-19 is associated with intense systemic inflammation and abnormal coagulation profile leading to an increased incidence of pulmonary embolism (PE). This study investigates whether PE in COVID-19 patients has different clinical, laboratory and radiological characteristics when compared to tradit...
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| Veröffentlicht in: | Journal of thrombosis and haemostasis 2025-01 |
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| creator | Sterpone, Paola Donadini, Marco Paolo Abatangelo, Irene Tofanelli, Laura Raza, Asim Piacentino, Filippo Vitale, Francesco Maria Ricapito, Francesco Venturini, Massimo Ageno, Walter Pavesi, Francesco Antonucci, Eleonora Cariati, Maurizio Podda, Gian Marco Birocchi, Simone |
| description | COVID-19 is associated with intense systemic inflammation and abnormal coagulation profile leading to an increased incidence of pulmonary embolism (PE). This study investigates whether PE in COVID-19 patients has different clinical, laboratory and radiological characteristics when compared to traditional PE in COVID negative patients.
We conducted an observational, multicentric, cross-sectional study on consecutive patients diagnosed with PE at admission or during hospital stay from February 21th 2019 to February 20th 2021. We compared clinical and laboratory data and Computer Tomography (CT) images between COVID-19 positive and COVID-19 negative patients. The extent of PE was evaluated using the Qanadli Index.
Among 771 enrolled patients with acute PE, 89 were COVID-19 positive. COVID-19 patients were predominantly male (59.6% vs. 41.5%; p=0.001) and exhibited fewer classic VTE risk factors, such as previous VTE (3.5% vs. 11.5%; p=0.02) and active cancer (4.7% vs. 24.2%; p |
| doi_str_mv | 10.1016/j.jtha.2024.12.037 |
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We conducted an observational, multicentric, cross-sectional study on consecutive patients diagnosed with PE at admission or during hospital stay from February 21th 2019 to February 20th 2021. We compared clinical and laboratory data and Computer Tomography (CT) images between COVID-19 positive and COVID-19 negative patients. The extent of PE was evaluated using the Qanadli Index.
Among 771 enrolled patients with acute PE, 89 were COVID-19 positive. COVID-19 patients were predominantly male (59.6% vs. 41.5%; p=0.001) and exhibited fewer classic VTE risk factors, such as previous VTE (3.5% vs. 11.5%; p=0.02) and active cancer (4.7% vs. 24.2%; p<0.0001). Additionally, these patients showed lower median Troponin-T and NT-proBNP levels (10 vs. 32 ng/L, p=0.0002; and 383 vs. 1448 pg/ml, p=0.004, respectively), a lower median Qanadli Index (4 vs. 7, p=0.0013), more distal PE obstructions (53.5% vs. 32.9%; p<0.001), and less frequent right ventricular dilatation (4.1% vs. 10.9%; p=0.09).
In COVID-19 patients, traditional VTE risk factors were less frequent, a possible role for in situ thrombo-inflammatory processes. The reduced radiological extent and severity of PE observed in COVID-19 patients may riflect an in situ thrombo-inflammatory process rather than classical embolization; however, this hypotesis need to be confirmed by other studies.</description><identifier>ISSN: 1538-7836</identifier><identifier>EISSN: 1538-7836</identifier><identifier>DOI: 10.1016/j.jtha.2024.12.037</identifier><identifier>PMID: 39800258</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Covid 19 ; immunothrombosis ; pulmonary embolism ; venous thromboembolism</subject><ispartof>Journal of thrombosis and haemostasis, 2025-01</ispartof><rights>2025</rights><rights>Copyright © 2025. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39800258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sterpone, Paola</creatorcontrib><creatorcontrib>Donadini, Marco Paolo</creatorcontrib><creatorcontrib>Abatangelo, Irene</creatorcontrib><creatorcontrib>Tofanelli, Laura</creatorcontrib><creatorcontrib>Raza, Asim</creatorcontrib><creatorcontrib>Piacentino, Filippo</creatorcontrib><creatorcontrib>Vitale, Francesco Maria</creatorcontrib><creatorcontrib>Ricapito, Francesco</creatorcontrib><creatorcontrib>Venturini, Massimo</creatorcontrib><creatorcontrib>Ageno, Walter</creatorcontrib><creatorcontrib>Pavesi, Francesco</creatorcontrib><creatorcontrib>Antonucci, Eleonora</creatorcontrib><creatorcontrib>Cariati, Maurizio</creatorcontrib><creatorcontrib>Podda, Gian Marco</creatorcontrib><creatorcontrib>Birocchi, Simone</creatorcontrib><title>DESCRIPTION OF THE CLINICAL AND RADIOLOGICAL CHARACTERISTICS OF PULMONARY EMBOLISM IN COVID-19 VERSUS NON COVID-19 PATIENTS: A MULTICENTRIC CROSS-SECTIONAL STUDY OVER A 24-MONTH PERSPECTIVE</title><title>Journal of thrombosis and haemostasis</title><addtitle>J Thromb Haemost</addtitle><description>COVID-19 is associated with intense systemic inflammation and abnormal coagulation profile leading to an increased incidence of pulmonary embolism (PE). This study investigates whether PE in COVID-19 patients has different clinical, laboratory and radiological characteristics when compared to traditional PE in COVID negative patients.
We conducted an observational, multicentric, cross-sectional study on consecutive patients diagnosed with PE at admission or during hospital stay from February 21th 2019 to February 20th 2021. We compared clinical and laboratory data and Computer Tomography (CT) images between COVID-19 positive and COVID-19 negative patients. The extent of PE was evaluated using the Qanadli Index.
Among 771 enrolled patients with acute PE, 89 were COVID-19 positive. COVID-19 patients were predominantly male (59.6% vs. 41.5%; p=0.001) and exhibited fewer classic VTE risk factors, such as previous VTE (3.5% vs. 11.5%; p=0.02) and active cancer (4.7% vs. 24.2%; p<0.0001). Additionally, these patients showed lower median Troponin-T and NT-proBNP levels (10 vs. 32 ng/L, p=0.0002; and 383 vs. 1448 pg/ml, p=0.004, respectively), a lower median Qanadli Index (4 vs. 7, p=0.0013), more distal PE obstructions (53.5% vs. 32.9%; p<0.001), and less frequent right ventricular dilatation (4.1% vs. 10.9%; p=0.09).
In COVID-19 patients, traditional VTE risk factors were less frequent, a possible role for in situ thrombo-inflammatory processes. The reduced radiological extent and severity of PE observed in COVID-19 patients may riflect an in situ thrombo-inflammatory process rather than classical embolization; however, this hypotesis need to be confirmed by other studies.</description><subject>Covid 19</subject><subject>immunothrombosis</subject><subject>pulmonary embolism</subject><subject>venous thromboembolism</subject><issn>1538-7836</issn><issn>1538-7836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNp9kcGO0zAURS0EYobCD7BAXrJJsJ04sRGbjJOhltI4ipNKs7LSxBWp2umQtEh8HP-GQwuaFfLC9tO59z37AvAeIx8jHH3a-bvTt9YniIQ-Jj4K4hfgFtOAeTELopfPzjfgzTTtEMKcEvQa3AScIUQouwW_0kyLSpa1VAVU97BeZlDkspAiyWFSpLBKUqly9fVPQSyTKhF1VkldS6FnQdnkK1Uk1QPMVncql3oFZQGFWsvUwxyus0o3GhbqWa1MapkVtf4ME7hqcufkbpUUUFRKa09nYp7GtdN1kz5A5TwcSULPNaqXsHSW5cyss7fg1bbdT_bddV-A5j6rxdK7Dux1mBLm0ditnuCQ0hBzjuOItxG3ASM85hHtLO7RhlAah9bhaMsQDqLtNt6gGGHc8mABPl58n8bj97OdTuYwTJ3d79tHezxPJsA0ZIwR99cLQC5oNx6nabRb8zQOh3b8aTAyc2xmZ-bYzBybwcS42Jzow9X_vDnY_p_kb04O-HIBrHvlj8GOZuoG-9jZfhhtdzL9cfif_28aOZf2</recordid><startdate>20250110</startdate><enddate>20250110</enddate><creator>Sterpone, Paola</creator><creator>Donadini, Marco Paolo</creator><creator>Abatangelo, Irene</creator><creator>Tofanelli, Laura</creator><creator>Raza, Asim</creator><creator>Piacentino, Filippo</creator><creator>Vitale, Francesco Maria</creator><creator>Ricapito, Francesco</creator><creator>Venturini, Massimo</creator><creator>Ageno, Walter</creator><creator>Pavesi, Francesco</creator><creator>Antonucci, Eleonora</creator><creator>Cariati, Maurizio</creator><creator>Podda, Gian Marco</creator><creator>Birocchi, Simone</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20250110</creationdate><title>DESCRIPTION OF THE CLINICAL AND RADIOLOGICAL CHARACTERISTICS OF PULMONARY EMBOLISM IN COVID-19 VERSUS NON COVID-19 PATIENTS: A MULTICENTRIC CROSS-SECTIONAL STUDY OVER A 24-MONTH PERSPECTIVE</title><author>Sterpone, Paola ; Donadini, Marco Paolo ; Abatangelo, Irene ; Tofanelli, Laura ; Raza, Asim ; Piacentino, Filippo ; Vitale, Francesco Maria ; Ricapito, Francesco ; Venturini, Massimo ; Ageno, Walter ; Pavesi, Francesco ; Antonucci, Eleonora ; Cariati, Maurizio ; Podda, Gian Marco ; Birocchi, Simone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1528-57575d2145541991769a69e38297965ce1d0b25574e5280f80136ff7b07011a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Covid 19</topic><topic>immunothrombosis</topic><topic>pulmonary embolism</topic><topic>venous thromboembolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sterpone, Paola</creatorcontrib><creatorcontrib>Donadini, Marco Paolo</creatorcontrib><creatorcontrib>Abatangelo, Irene</creatorcontrib><creatorcontrib>Tofanelli, Laura</creatorcontrib><creatorcontrib>Raza, Asim</creatorcontrib><creatorcontrib>Piacentino, Filippo</creatorcontrib><creatorcontrib>Vitale, Francesco Maria</creatorcontrib><creatorcontrib>Ricapito, Francesco</creatorcontrib><creatorcontrib>Venturini, Massimo</creatorcontrib><creatorcontrib>Ageno, Walter</creatorcontrib><creatorcontrib>Pavesi, Francesco</creatorcontrib><creatorcontrib>Antonucci, Eleonora</creatorcontrib><creatorcontrib>Cariati, Maurizio</creatorcontrib><creatorcontrib>Podda, Gian Marco</creatorcontrib><creatorcontrib>Birocchi, Simone</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sterpone, Paola</au><au>Donadini, Marco Paolo</au><au>Abatangelo, Irene</au><au>Tofanelli, Laura</au><au>Raza, Asim</au><au>Piacentino, Filippo</au><au>Vitale, Francesco Maria</au><au>Ricapito, Francesco</au><au>Venturini, Massimo</au><au>Ageno, Walter</au><au>Pavesi, Francesco</au><au>Antonucci, Eleonora</au><au>Cariati, Maurizio</au><au>Podda, Gian Marco</au><au>Birocchi, Simone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DESCRIPTION OF THE CLINICAL AND RADIOLOGICAL CHARACTERISTICS OF PULMONARY EMBOLISM IN COVID-19 VERSUS NON COVID-19 PATIENTS: A MULTICENTRIC CROSS-SECTIONAL STUDY OVER A 24-MONTH PERSPECTIVE</atitle><jtitle>Journal of thrombosis and haemostasis</jtitle><addtitle>J Thromb Haemost</addtitle><date>2025-01-10</date><risdate>2025</risdate><issn>1538-7836</issn><eissn>1538-7836</eissn><abstract>COVID-19 is associated with intense systemic inflammation and abnormal coagulation profile leading to an increased incidence of pulmonary embolism (PE). This study investigates whether PE in COVID-19 patients has different clinical, laboratory and radiological characteristics when compared to traditional PE in COVID negative patients.
We conducted an observational, multicentric, cross-sectional study on consecutive patients diagnosed with PE at admission or during hospital stay from February 21th 2019 to February 20th 2021. We compared clinical and laboratory data and Computer Tomography (CT) images between COVID-19 positive and COVID-19 negative patients. The extent of PE was evaluated using the Qanadli Index.
Among 771 enrolled patients with acute PE, 89 were COVID-19 positive. COVID-19 patients were predominantly male (59.6% vs. 41.5%; p=0.001) and exhibited fewer classic VTE risk factors, such as previous VTE (3.5% vs. 11.5%; p=0.02) and active cancer (4.7% vs. 24.2%; p<0.0001). Additionally, these patients showed lower median Troponin-T and NT-proBNP levels (10 vs. 32 ng/L, p=0.0002; and 383 vs. 1448 pg/ml, p=0.004, respectively), a lower median Qanadli Index (4 vs. 7, p=0.0013), more distal PE obstructions (53.5% vs. 32.9%; p<0.001), and less frequent right ventricular dilatation (4.1% vs. 10.9%; p=0.09).
In COVID-19 patients, traditional VTE risk factors were less frequent, a possible role for in situ thrombo-inflammatory processes. The reduced radiological extent and severity of PE observed in COVID-19 patients may riflect an in situ thrombo-inflammatory process rather than classical embolization; however, this hypotesis need to be confirmed by other studies.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>39800258</pmid><doi>10.1016/j.jtha.2024.12.037</doi></addata></record> |
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| subjects | Covid 19 immunothrombosis pulmonary embolism venous thromboembolism |
| title | DESCRIPTION OF THE CLINICAL AND RADIOLOGICAL CHARACTERISTICS OF PULMONARY EMBOLISM IN COVID-19 VERSUS NON COVID-19 PATIENTS: A MULTICENTRIC CROSS-SECTIONAL STUDY OVER A 24-MONTH PERSPECTIVE |
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