Aging and voluntary exercise’s effects on Aβ1-42 levels, endoplasmic reticulum stress factors, and apoptosis in the hippocampus of old male rats

[Display omitted] •Voluntary exercise reduces Aβ1-42 and inhibits apoptotic pathways in old rats.•Exercise reduces ATF6, CHOP, and p-PERK proteins while increasing Bcl-2 expression.•The impact of exercise on UPR signaling pathways in the hippocampus is shown.•Findings suggest exercise as a promising...

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Veröffentlicht in:	Brain research 2025-01, Vol.1850, p.149447, Article 149447
Hauptverfasser:	Derafshpour, Leila, Niazi, Mona, Pourheydar, Bagher, Roshan-Milani, Shiva, Asghariehahari, Morteza, Chodari, Leila
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Amyloid Beta1-42 Apoptosis Endoplasmic reticulum stress Voluntary exercise
Online-Zugang:	Volltext
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