Analysis of fibrinogenolytic activity of South American Bothrops and Crotalus venoms reveals widespread variation on human fibrinogen cleavage
Fibrinogen is a common target of SVMP and SVSP. These toxins can destructively cleave fibrinogen, leading to the depletion of its levels. Herein we comparatively describe the fibrinogenolytic activity of the venom of Bothrops and Crotalus snakes, viperids of high epidemiological importance in Brazil...
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| Veröffentlicht in: | Toxicon (Oxford) 2025-02, Vol.255, p.108236, Article 108236 |
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| container_title | Toxicon (Oxford) |
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| creator | Motta Soares, Maria Victória da Costa Galizio, Nathália Teixeira da Rocha, Marisa Maria Grego, Kathleen Fernandes Tanaka-Azevedo, Anita Mitico de Morais-Zani, Karen |
| description | Fibrinogen is a common target of SVMP and SVSP. These toxins can destructively cleave fibrinogen, leading to the depletion of its levels. Herein we comparatively describe the fibrinogenolytic activity of the venom of Bothrops and Crotalus snakes, viperids of high epidemiological importance in Brazil. Results emphasize species-specific differences in the degradation rate and the specificity of the preferentially degraded fibrinogen chains, reflecting the complexity of the coagulotoxic effects induced by envenomation.
[Display omitted]
•We comparatively describe the fibrinogenolytic activity of Bothrops and Crotalus snake venoms.•Data describe the specificity of the preferentially degraded fibrinogen chains.•Results highlight species-specific differences in the fibrinogen degradation rate.•This work emphasizes the complexity of the coagulotoxic effects induced by envenomation. |
| doi_str_mv | 10.1016/j.toxicon.2025.108236 |
| format | Article |
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[Display omitted]
•We comparatively describe the fibrinogenolytic activity of Bothrops and Crotalus snake venoms.•Data describe the specificity of the preferentially degraded fibrinogen chains.•Results highlight species-specific differences in the fibrinogen degradation rate.•This work emphasizes the complexity of the coagulotoxic effects induced by envenomation.</description><identifier>ISSN: 0041-0101</identifier><identifier>ISSN: 1879-3150</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/j.toxicon.2025.108236</identifier><identifier>PMID: 39793628</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><ispartof>Toxicon (Oxford), 2025-02, Vol.255, p.108236, Article 108236</ispartof><rights>2025 Elsevier Ltd</rights><rights>Copyright © 2025 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1588-a2924190fbeafa4ee0758d80126f468c490ba6bbc9cb44420cf1fa31069835d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041010125000108$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39793628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motta Soares, Maria Victória</creatorcontrib><creatorcontrib>da Costa Galizio, Nathália</creatorcontrib><creatorcontrib>Teixeira da Rocha, Marisa Maria</creatorcontrib><creatorcontrib>Grego, Kathleen Fernandes</creatorcontrib><creatorcontrib>Tanaka-Azevedo, Anita Mitico</creatorcontrib><creatorcontrib>de Morais-Zani, Karen</creatorcontrib><title>Analysis of fibrinogenolytic activity of South American Bothrops and Crotalus venoms reveals widespread variation on human fibrinogen cleavage</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Fibrinogen is a common target of SVMP and SVSP. These toxins can destructively cleave fibrinogen, leading to the depletion of its levels. Herein we comparatively describe the fibrinogenolytic activity of the venom of Bothrops and Crotalus snakes, viperids of high epidemiological importance in Brazil. Results emphasize species-specific differences in the degradation rate and the specificity of the preferentially degraded fibrinogen chains, reflecting the complexity of the coagulotoxic effects induced by envenomation.
[Display omitted]
•We comparatively describe the fibrinogenolytic activity of Bothrops and Crotalus snake venoms.•Data describe the specificity of the preferentially degraded fibrinogen chains.•Results highlight species-specific differences in the fibrinogen degradation rate.•This work emphasizes the complexity of the coagulotoxic effects induced by envenomation.</description><issn>0041-0101</issn><issn>1879-3150</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><recordid>eNqFkc2u0zAQhS0E4pYLjwDykk3KOHZSZ4VKxZ90JRbA2nKc8a2rxC62k0tfgmfGVQsskUayNP7OHM0cQl4yWDNg7ZvDOoefzgS_rqFuSk_WvH1EVkxuuoqzBh6TFYBgFRT8hjxL6QAAXHbtU3LDu03H21quyK-t1-MpuUSDpdb10flwjz6Mp-wM1Sa7xeXT-fNrmPOebieMzmhP34W8j-GYqPYD3cWQ9TgnuhTplGjEBfWY6IMbMB0j6oEuOjqdXfC01H6eyoh_dtSMqBd9j8_JE1uE-OL63pLvH95_232q7r58_Lzb3lWGNVJWuu5qwTqwPWqrBSJsGjlIYHVrRSuN6KDXbd-bzvRCiBqMZVZzBm0neTMAvyWvL3OPMfyYMWU1uWRwHLXHMCdVDigE8EaygjYX1MSQUkSrjtFNOp4UA3WOQh3UNQp1jkJdoii6V1eLuZ9w-Kv6c_sCvL0AWBZdHEaVjENvcHARTVZDcP-x-A0ZmqCH</recordid><startdate>202502</startdate><enddate>202502</enddate><creator>Motta Soares, Maria Victória</creator><creator>da Costa Galizio, Nathália</creator><creator>Teixeira da Rocha, Marisa Maria</creator><creator>Grego, Kathleen Fernandes</creator><creator>Tanaka-Azevedo, Anita Mitico</creator><creator>de Morais-Zani, Karen</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202502</creationdate><title>Analysis of fibrinogenolytic activity of South American Bothrops and Crotalus venoms reveals widespread variation on human fibrinogen cleavage</title><author>Motta Soares, Maria Victória ; da Costa Galizio, Nathália ; Teixeira da Rocha, Marisa Maria ; Grego, Kathleen Fernandes ; Tanaka-Azevedo, Anita Mitico ; de Morais-Zani, Karen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1588-a2924190fbeafa4ee0758d80126f468c490ba6bbc9cb44420cf1fa31069835d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motta Soares, Maria Victória</creatorcontrib><creatorcontrib>da Costa Galizio, Nathália</creatorcontrib><creatorcontrib>Teixeira da Rocha, Marisa Maria</creatorcontrib><creatorcontrib>Grego, Kathleen Fernandes</creatorcontrib><creatorcontrib>Tanaka-Azevedo, Anita Mitico</creatorcontrib><creatorcontrib>de Morais-Zani, Karen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motta Soares, Maria Victória</au><au>da Costa Galizio, Nathália</au><au>Teixeira da Rocha, Marisa Maria</au><au>Grego, Kathleen Fernandes</au><au>Tanaka-Azevedo, Anita Mitico</au><au>de Morais-Zani, Karen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of fibrinogenolytic activity of South American Bothrops and Crotalus venoms reveals widespread variation on human fibrinogen cleavage</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>2025-02</date><risdate>2025</risdate><volume>255</volume><spage>108236</spage><pages>108236-</pages><artnum>108236</artnum><issn>0041-0101</issn><issn>1879-3150</issn><eissn>1879-3150</eissn><abstract>Fibrinogen is a common target of SVMP and SVSP. These toxins can destructively cleave fibrinogen, leading to the depletion of its levels. Herein we comparatively describe the fibrinogenolytic activity of the venom of Bothrops and Crotalus snakes, viperids of high epidemiological importance in Brazil. Results emphasize species-specific differences in the degradation rate and the specificity of the preferentially degraded fibrinogen chains, reflecting the complexity of the coagulotoxic effects induced by envenomation.
[Display omitted]
•We comparatively describe the fibrinogenolytic activity of Bothrops and Crotalus snake venoms.•Data describe the specificity of the preferentially degraded fibrinogen chains.•Results highlight species-specific differences in the fibrinogen degradation rate.•This work emphasizes the complexity of the coagulotoxic effects induced by envenomation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39793628</pmid><doi>10.1016/j.toxicon.2025.108236</doi></addata></record> |
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| title | Analysis of fibrinogenolytic activity of South American Bothrops and Crotalus venoms reveals widespread variation on human fibrinogen cleavage |
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