Radiosynthesis and evaluation of novel 18F labeled PET ligands for imaging monoacylglycerol lipase

Monoacylglycerol lipase (MAGL) is a 33 kDa cytosolic serine hydrolase that is widely distributed in the central nervous system and peripheral tissues. MAGL hydrolyzes monoacylglycerols into fatty acids and glycerol, playing a crucial role in endocannabinoid degradation. Inhibition of MAGL in the bra...

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Veröffentlicht in:	European journal of medicinal chemistry 2025-03, Vol.285, p.117246, Article 117246
Hauptverfasser:	Li, Yinlong, Mori, Wakana, Chaudhary, Ahmad, Zhao, Chunyu, Yamasaki, Tomoteru, Zhang, Zachary, Feng, Siyan, Ware, Tim, Rong, Jian, Fujinaga, Masayuki, Chen, Jiahui, Kumata, Katsushi, Zhang, Yiding, Hu, Kuan, Xie, Lin, Zhou, Xin, Song, Zhendong, Gao, Yabiao, Sun, Zhenkun, Patel, Jimmy S., Zhai, Chuangyan, Yuan, Katherine Y., Collier, Thomas L., Ran, Chongzhao, Collin, Ludovic, Haider, Achi, Grether, Uwe, Wittwer, Matthias B., Cravatt, Benjamin F., Zhang, Ming-Rong, Liang, Steven H.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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