Construction with recombinant epitope-expressing baculovirus enhances protective effects of inactivated H9N2 vaccine against heterologous virus

Although the use of inactivated vaccines has kept avian influenza (AI) outbreaks largely under control, they fail to prevent virus shedding. To enhance the efficacy of inactivated H9N2 AIV vaccines (InV), we constructed a multi-epitope recombinant baculovirus (BV-BNT) containing two B cell epitopes...

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Veröffentlicht in:	Veterinary microbiology 2025-01, Vol.300, p.110337, Article 110337
Hauptverfasser:	Xie, Zimin, Chen, Yingyi, Xie, Jun, Du, Shanyao, Chen, Rongmao, Zheng, Yuqin, You, Bowen, Feng, Min, Liao, Ming, Dai, Manman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood avian influenza B cell epitopes B-lymphocytes Baculoviridae Baculoviridae - genetics Baculovirus CD8-Positive T-Lymphocytes - immunology Chickens cloaca Cytokines - metabolism epitopes Epitopes - immunology Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology H9N2 AIV immunization Inactivated vaccine Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - immunology Influenza in Birds - immunology Influenza in Birds - prevention & control Influenza in Birds - virology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology interleukin-13 interleukin-4 splenocytes T cell epitopes T-lymphocytes vaccines Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology viral load viruses
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