Transcriptional regulation of multi-tissue mRNA expression by L-arabinose mitigates metabolic disorders in leptin receptor-deficient mice

L-arabinose, a sugar substitute, exhibits anti-diabetic effects due to its lower caloric content than conventional sugar. However, the comprehensive molecular mechanisms underlying its organ-to-organ interactions remain elusive in transgenic mouse models. Therefore, we investigated these anti-diabet...

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Veröffentlicht in:	Food bioscience 2024-10, Vol.61, p.104881, Article 104881
Hauptverfasser:	Han, Youngji, Jeong, Yuri, Lee, Jin Hyup, Pack, Seung Pil
Format:	Artikel
Sprache:	eng
Schlagworte:	arabinose beta oxidation blood glucose body fat diabetes diet energy content energy intake enzyme activity erythritol fatty acid metabolism gene expression genetically modified organisms glucose tolerance glycolysis inflammation Insulin receptor-deficient mice insulin resistance L-arabinose Leptin mice mRNA-sequencing muscle development sarcopenia sucrose Sugar substitute therapeutics transcription (genetics)
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