Investigating the stability of a cerebral vasodilator drug using chromatographic methods: Evaluation of methods’ practicality and environmental aspects

[Display omitted] •Studying vinburnine degradation undervariable ICH stress conditions.•The first developed stability indicating chromatographic methods.•Method greenness profile has been checkedand they were succeeded to be ecofriendly.•HPLC method has short analysis time (=5 min) and hence low sol...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2024-12, Vol.1249, p.124371, Article 124371
Hauptverfasser:	Al-Mohaimeed, Amal M., El-Tohamy, Maha F., Ali, Mohamed G.H., Habib, Neven M., Abdelwahab, Nada S., Abdelrahman, Maha M., Mahmoud, Hamada M., Emam, Aml A.
Format:	Artikel
Sprache:	eng
Schlagworte:	alkaloids carboxylic acids chromatography Chromatography, High Pressure Liquid - methods Chromatography, Reverse-Phase - methods Chromatography, Thin Layer - methods Densitometry - methods Drug Stability drugs environmental impact ethyl acetate Greenness profile Limit of Detection Linear Models methanol prediction Reproducibility of Results RP-HPLC silica gel Stability indicating methods TLC triethylamine Vasodilator Agents - analysis Vasodilator Agents - chemistry Vinburnine
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