Biodegradable iridium coordinated nanodrugs potentiate photodynamic therapy and immunotherapy of lung cancer

[Display omitted] Hypoxia, which is a common characteristic of most solid tumors, not only contributes to the immunosuppressive nature of the tumor microenvironment (TME) but also reduces the efficacy of many oxygen-depleting therapies, including photodynamic therapy (PDT). In this study, we develop...

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Veröffentlicht in:	Journal of colloid and interface science 2025-02, Vol.680 (Pt A), p.9-24
Hauptverfasser:	Li, Jingyao, Yi, Huixi, Fu, Yuanyuan, Zhuang, Jiani, Zhan, Zhixiong, Guo, Liyou, Zheng, Ji, Yu, Xiyong, Zhang, Dong-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology biodegradability cell death Cell Proliferation - drug effects Cell Survival - drug effects chlorins Chlorophyllides Drug Screening Assays, Antitumor glutathione Humans hydrogen peroxide Hypoxia immunosuppression Immunotherapy Iridium Iridium - chemistry Iridium - pharmacology irradiation lung neoplasms Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - therapy Mice Mice, Inbred BALB C Nanoparticles - chemistry oxygen Particle Size Photochemotherapy Photodynamic therapy photosensitizing agents Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology polyvinylpyrrolidone Porphyrins - chemistry Porphyrins - pharmacology Povidone - chemistry Povidone - pharmacology Reactive Oxygen Species - metabolism Self-assembly Surface Properties toxicity Tumor microenvironment Tumor Microenvironment - drug effects
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