Systematic Profiling and Quantitative Comparison of Chemical Components in Fagopyri Dibotryis Rhizoma From Different Habitats and Growing Periods Based on Ultra‐High‐Performance Liquid Chromatography With Mass Spectrometry
ABSTRACT Fagopyri Dibotryis Rhizoma, a traditional Chinese medicine, is widely used to treat various ailments such as pulmonary abscesses, measles pneumonia, and swelling. Its notable therapeutic effects are closely related to the chemical constituents, making it crucial to conduct in‐depth research...
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| creator | Wu, Didi Qu, Cheng Yu, Daixin Yang, Fan Wu, Qinan |
| description | ABSTRACT
Fagopyri Dibotryis Rhizoma, a traditional Chinese medicine, is widely used to treat various ailments such as pulmonary abscesses, measles pneumonia, and swelling. Its notable therapeutic effects are closely related to the chemical constituents, making it crucial to conduct in‐depth research on the chemical components. In this study, a total of 209 compounds were preliminarily identified using ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry in Fagopyri Dibotryis Rhizoma. Subsequently, a method was established using ultra‐high‐performance liquid chromatography‐triple quadrupole/linear ion trap tandem mass spectrometry for the simultaneous determination of 24 main ingredients (flavonoids and phenolic acids) in Fagopyri Dibotryis Rhizoma from different habitats and growing periods. Quantitative results showed that different compounds displayed varying contents across different habitats, with catechin, epicatechin, procyanidin B2, and procyanidin C1 being relatively abundant. Principal component analysis and partial least squares discriminant analysis showed there were significant differences among Fagopyri Dibotryis Rhizoma from different habitats, and the quality from Yunnan was superior. Entropy weight TOPSIS analysis showed that Fagopyri Dibotryis Rhizoma grown until late October has better comprehensive quality, which is basically consistent with the traditional harvesting time. In summary, this study can provide reference methods for the comprehensive evaluation of the quality of Fagopyri Dibotryis Rhizoma. |
| doi_str_mv | 10.1002/jssc.70037 |
| format | Article |
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Fagopyri Dibotryis Rhizoma, a traditional Chinese medicine, is widely used to treat various ailments such as pulmonary abscesses, measles pneumonia, and swelling. Its notable therapeutic effects are closely related to the chemical constituents, making it crucial to conduct in‐depth research on the chemical components. In this study, a total of 209 compounds were preliminarily identified using ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry in Fagopyri Dibotryis Rhizoma. Subsequently, a method was established using ultra‐high‐performance liquid chromatography‐triple quadrupole/linear ion trap tandem mass spectrometry for the simultaneous determination of 24 main ingredients (flavonoids and phenolic acids) in Fagopyri Dibotryis Rhizoma from different habitats and growing periods. Quantitative results showed that different compounds displayed varying contents across different habitats, with catechin, epicatechin, procyanidin B2, and procyanidin C1 being relatively abundant. Principal component analysis and partial least squares discriminant analysis showed there were significant differences among Fagopyri Dibotryis Rhizoma from different habitats, and the quality from Yunnan was superior. Entropy weight TOPSIS analysis showed that Fagopyri Dibotryis Rhizoma grown until late October has better comprehensive quality, which is basically consistent with the traditional harvesting time. In summary, this study can provide reference methods for the comprehensive evaluation of the quality of Fagopyri Dibotryis Rhizoma.</description><identifier>ISSN: 1615-9306</identifier><identifier>ISSN: 1615-9314</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.70037</identifier><identifier>PMID: 39623563</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Catechin ; China ; Chromatography ; Chromatography, High Pressure Liquid ; different habitats ; Discriminant analysis ; Drugs, Chinese Herbal - analysis ; Drugs, Chinese Herbal - chemistry ; Ecosystem ; entropy ; epicatechin ; Fagopyri Dibotryis Rhizoma ; Fagopyrum - chemistry ; Flavonoids ; Flavonoids - analysis ; growing periods ; Habitats ; Liquid chromatography ; Mass spectrometry ; Mass Spectrometry - methods ; measles ; Oriental traditional medicine ; Phenolic acids ; pneumonia ; principal component analysis ; Principal components analysis ; Procyanidins ; Quadrupoles ; Rhizome - chemistry ; rhizomes ; Scientific imaging ; separation ; tandem mass spectrometry ; Tandem Mass Spectrometry - methods ; therapeutics ; Traditional Chinese medicine ; ultra-performance liquid chromatography</subject><ispartof>Journal of separation science, 2024-12, Vol.47 (23), p.e70037-n/a</ispartof><rights>2024 Wiley‐VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2797-58cdfc12fee6e4737def92c9de2df15ef9917551f73f1a56fdb16b71b9e93b793</cites><orcidid>0009-0003-8332-6929</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.70037$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.70037$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39623563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Didi</creatorcontrib><creatorcontrib>Qu, Cheng</creatorcontrib><creatorcontrib>Yu, Daixin</creatorcontrib><creatorcontrib>Yang, Fan</creatorcontrib><creatorcontrib>Wu, Qinan</creatorcontrib><title>Systematic Profiling and Quantitative Comparison of Chemical Components in Fagopyri Dibotryis Rhizoma From Different Habitats and Growing Periods Based on Ultra‐High‐Performance Liquid Chromatography With Mass Spectrometry</title><title>Journal of separation science</title><addtitle>J Sep Sci</addtitle><description>ABSTRACT
Fagopyri Dibotryis Rhizoma, a traditional Chinese medicine, is widely used to treat various ailments such as pulmonary abscesses, measles pneumonia, and swelling. Its notable therapeutic effects are closely related to the chemical constituents, making it crucial to conduct in‐depth research on the chemical components. In this study, a total of 209 compounds were preliminarily identified using ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry in Fagopyri Dibotryis Rhizoma. Subsequently, a method was established using ultra‐high‐performance liquid chromatography‐triple quadrupole/linear ion trap tandem mass spectrometry for the simultaneous determination of 24 main ingredients (flavonoids and phenolic acids) in Fagopyri Dibotryis Rhizoma from different habitats and growing periods. Quantitative results showed that different compounds displayed varying contents across different habitats, with catechin, epicatechin, procyanidin B2, and procyanidin C1 being relatively abundant. Principal component analysis and partial least squares discriminant analysis showed there were significant differences among Fagopyri Dibotryis Rhizoma from different habitats, and the quality from Yunnan was superior. Entropy weight TOPSIS analysis showed that Fagopyri Dibotryis Rhizoma grown until late October has better comprehensive quality, which is basically consistent with the traditional harvesting time. In summary, this study can provide reference methods for the comprehensive evaluation of the quality of Fagopyri Dibotryis Rhizoma.</description><subject>Catechin</subject><subject>China</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>different habitats</subject><subject>Discriminant analysis</subject><subject>Drugs, Chinese Herbal - analysis</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Ecosystem</subject><subject>entropy</subject><subject>epicatechin</subject><subject>Fagopyri Dibotryis Rhizoma</subject><subject>Fagopyrum - chemistry</subject><subject>Flavonoids</subject><subject>Flavonoids - analysis</subject><subject>growing periods</subject><subject>Habitats</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>measles</subject><subject>Oriental traditional medicine</subject><subject>Phenolic acids</subject><subject>pneumonia</subject><subject>principal component analysis</subject><subject>Principal components analysis</subject><subject>Procyanidins</subject><subject>Quadrupoles</subject><subject>Rhizome - chemistry</subject><subject>rhizomes</subject><subject>Scientific imaging</subject><subject>separation</subject><subject>tandem mass spectrometry</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>therapeutics</subject><subject>Traditional Chinese medicine</subject><subject>ultra-performance liquid chromatography</subject><issn>1615-9306</issn><issn>1615-9314</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9u1DAQhyMEon_gwgMgS1xQpS12nMTrIwS2C1pEYak4Ro4z3vUqsVPboQonHoFn7JPg7JYeOCBOtmc-fTOWfknyjOBzgnH6aue9PGcYU_YgOSYFyWeckuzh_R0XR8mJ9zuMCZtz_Dg5orxIaV7Q4-R2PfoAnQhaoktnlW612SBhGvR5ECboEDvfAZW264XT3hpkFSq30Gkp2n3ZGjDBI23QQmxsPzqN3uraBjdqj75s9Q_bCbRwtotlpcBFGi1FPZn9ftCFszfT0Etw2jYevREeGhQnXbXBidufv5Z6s41H7CvrOmEkoJW-HnQTF4leEezGiX47om86bNFH4T1a9yBD7EFc40nySInWw9O78zS5Wrz7Wi5nq08X78vXq5lMGWezfC4bJUmqAArIGGUNKJ5K3kDaKJLHBycsz4liVBGRF6qpSVEzUnPgtGacniYvD97e2esBfKg67SW0rTBgB19RkmdpkbI5-w80wzylWZZH9MVf6M4OzsSPTBQtJmMWqbMDJZ313oGqeqc74caK4GoKSTWFpNqHJMLP75RD3UFzj_5JRQTIAbjRLYz_UFUf1uvyIP0NB5fOxg</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Wu, Didi</creator><creator>Qu, Cheng</creator><creator>Yu, Daixin</creator><creator>Yang, Fan</creator><creator>Wu, Qinan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0009-0003-8332-6929</orcidid></search><sort><creationdate>202412</creationdate><title>Systematic Profiling and Quantitative Comparison of Chemical Components in Fagopyri Dibotryis Rhizoma From Different Habitats and Growing Periods Based on Ultra‐High‐Performance Liquid Chromatography With Mass Spectrometry</title><author>Wu, Didi ; Qu, Cheng ; Yu, Daixin ; Yang, Fan ; Wu, Qinan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2797-58cdfc12fee6e4737def92c9de2df15ef9917551f73f1a56fdb16b71b9e93b793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Catechin</topic><topic>China</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>different habitats</topic><topic>Discriminant analysis</topic><topic>Drugs, Chinese Herbal - analysis</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Ecosystem</topic><topic>entropy</topic><topic>epicatechin</topic><topic>Fagopyri Dibotryis Rhizoma</topic><topic>Fagopyrum - chemistry</topic><topic>Flavonoids</topic><topic>Flavonoids - analysis</topic><topic>growing periods</topic><topic>Habitats</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>measles</topic><topic>Oriental traditional medicine</topic><topic>Phenolic acids</topic><topic>pneumonia</topic><topic>principal component analysis</topic><topic>Principal components analysis</topic><topic>Procyanidins</topic><topic>Quadrupoles</topic><topic>Rhizome - chemistry</topic><topic>rhizomes</topic><topic>Scientific imaging</topic><topic>separation</topic><topic>tandem mass spectrometry</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>therapeutics</topic><topic>Traditional Chinese medicine</topic><topic>ultra-performance liquid chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Didi</creatorcontrib><creatorcontrib>Qu, Cheng</creatorcontrib><creatorcontrib>Yu, Daixin</creatorcontrib><creatorcontrib>Yang, Fan</creatorcontrib><creatorcontrib>Wu, Qinan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Didi</au><au>Qu, Cheng</au><au>Yu, Daixin</au><au>Yang, Fan</au><au>Wu, Qinan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systematic Profiling and Quantitative Comparison of Chemical Components in Fagopyri Dibotryis Rhizoma From Different Habitats and Growing Periods Based on Ultra‐High‐Performance Liquid Chromatography With Mass Spectrometry</atitle><jtitle>Journal of separation science</jtitle><addtitle>J Sep Sci</addtitle><date>2024-12</date><risdate>2024</risdate><volume>47</volume><issue>23</issue><spage>e70037</spage><epage>n/a</epage><pages>e70037-n/a</pages><issn>1615-9306</issn><issn>1615-9314</issn><eissn>1615-9314</eissn><abstract>ABSTRACT
Fagopyri Dibotryis Rhizoma, a traditional Chinese medicine, is widely used to treat various ailments such as pulmonary abscesses, measles pneumonia, and swelling. Its notable therapeutic effects are closely related to the chemical constituents, making it crucial to conduct in‐depth research on the chemical components. In this study, a total of 209 compounds were preliminarily identified using ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry in Fagopyri Dibotryis Rhizoma. Subsequently, a method was established using ultra‐high‐performance liquid chromatography‐triple quadrupole/linear ion trap tandem mass spectrometry for the simultaneous determination of 24 main ingredients (flavonoids and phenolic acids) in Fagopyri Dibotryis Rhizoma from different habitats and growing periods. Quantitative results showed that different compounds displayed varying contents across different habitats, with catechin, epicatechin, procyanidin B2, and procyanidin C1 being relatively abundant. Principal component analysis and partial least squares discriminant analysis showed there were significant differences among Fagopyri Dibotryis Rhizoma from different habitats, and the quality from Yunnan was superior. Entropy weight TOPSIS analysis showed that Fagopyri Dibotryis Rhizoma grown until late October has better comprehensive quality, which is basically consistent with the traditional harvesting time. In summary, this study can provide reference methods for the comprehensive evaluation of the quality of Fagopyri Dibotryis Rhizoma.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39623563</pmid><doi>10.1002/jssc.70037</doi><tpages>14</tpages><orcidid>https://orcid.org/0009-0003-8332-6929</orcidid></addata></record> |
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| subjects | Catechin China Chromatography Chromatography, High Pressure Liquid different habitats Discriminant analysis Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - chemistry Ecosystem entropy epicatechin Fagopyri Dibotryis Rhizoma Fagopyrum - chemistry Flavonoids Flavonoids - analysis growing periods Habitats Liquid chromatography Mass spectrometry Mass Spectrometry - methods measles Oriental traditional medicine Phenolic acids pneumonia principal component analysis Principal components analysis Procyanidins Quadrupoles Rhizome - chemistry rhizomes Scientific imaging separation tandem mass spectrometry Tandem Mass Spectrometry - methods therapeutics Traditional Chinese medicine ultra-performance liquid chromatography |
| title | Systematic Profiling and Quantitative Comparison of Chemical Components in Fagopyri Dibotryis Rhizoma From Different Habitats and Growing Periods Based on Ultra‐High‐Performance Liquid Chromatography With Mass Spectrometry |
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