Genetic and epigenetic analyses of IFN-γ gene proximal promoter region underlying positive correlation between persistently high anti-SARS-CoV-2 IgG and IFN-γ among COVID-19 vaccinated Bangladeshi adults

IFN-γ is an immunological modulator influencing IgG isotype and concentration, which present a correlate of protection to evaluate vaccine efficacy. As transiently expressed, stable genetic and epigenetic signatures of the cytokine's expression may exist. This study investigates correlation bet...

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Veröffentlicht in:	Vaccine 2024-08, Vol.42 (21), p.126157, Article 126157
Hauptverfasser:	Tahsin, Anika, Bhattacharjee, Piyash, Al Saba, Abdullah, Yasmin, Tahirah, Nabi, A.H.M. Nurun
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Adults Anti-SARS-CoV-2 IgG Antibodies Correlation analysis COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccines Cytokines DNA methylation Epigenetics Evaluation Gene polymorphism Gene sequencing genes Genetic analysis Genetic diversity Genetic polymorphism heterozygosity Humoral immunity IFN-γ IFN-γ proximal promoter Immunoglobulin G Immunology Infections Lymphocytes mRNA Nucleotides Plasma Plasma levels Population studies promoter regions Proteins seroprevalence Severe acute respiratory syndrome coronavirus 2 Statistical analysis vaccination Vaccine efficacy vaccines γ-Interferon
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