High-resolution targeted mass spectrometry for comprehensive quantification of sphingolipids: clinical applications and characterization of extracellular vesicles

Sphingolipids (SL), a class of membrane lipids, play important roles in numerous biological processes. Their significant structural diversity poses challenges for accurate quantification. To address this, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) has emerged as a powerfu...

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Veröffentlicht in:	Analytical biochemistry 2025-03, Vol.698, p.115732, Article 115732
Hauptverfasser:	Felippe, Thiago V.D., Toro, Diana M., de Carvalho, Jonatan C.S., Nobre-Azevedo, Pedro, Rodrigues, Luiz F.M., Oliveira, Bianca T.M., da Silva-Neto, Pedro V., Vilela, Adriana F.L., Almeida, Fausto, Faccioli, Lúcia H., Sorgi, Carlos A.
Format:	Artikel
Sprache:	eng
Schlagworte:	biomarkers class COVID-19 COVID-19 infection Extracellular vesicles LC-MS/MS liquid chromatography metabolism species Sphingolipids tandem mass spectrometry therapeutics
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