Exploring the Mechanisms of Indole-Oxadiazole Benzamide Hybrids as Tyrosinase Inhibitors: Insights from Lineweaver-Burk Plot Analysis and Computational Studies

Objective: This study aimed to synthesize hybrid compounds incorporating indole, oxadiazole, and benzamide moieties, leveraging their known biological activities, to evaluate their potential as tyrosinase inhibitors. Methods: A convergent synthetic approach was employed to develop the hybrid compoun...

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Veröffentlicht in:	Russian journal of bioorganic chemistry 2024-12, Vol.50 (6), p.2325-2343
Hauptverfasser:	Nazir, M., Khan, U., Jahangir, M., Hayat, K., Bokhari, S. A. R., Shakoor, A., Ahmad, E., Haider, H. M. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamide benzamides Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry carbon Chemical analysis Effectiveness Electrons energy Energy value Enzyme kinetics indoles Infrared analysis Infrared spectroscopy Inhibitors Life Sciences NMR Nuclear magnetic resonance nuclear magnetic resonance spectroscopy Organic Chemistry Oxadiazoles structure-activity relationships therapeutics Tyrosinase
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