LncRNA USP2-AS1 facilitates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting KDM3A/ETS1/USP2 to activate the Wnt/β-catenin signaling pathway

Human bone marrow mesenchymal stem cells (HBMSCs) can promote new bone formation. Previous studies have proven the ability of long non-coding RNAs (lncRNAs) to modulate the osteogenic differentiation of mesenchymal stem cells. However, the molecular mechanism modulated by lncRNAs in affecting the os...

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Veröffentlicht in:	RNA biology 2024-12, Vol.21 (1), p.89-101
Hauptverfasser:	Luo, Wanxin, Zhang, Na, Wang, Ziping, Chen, Hao, Sun, Jie, Yao, Chen, Zhang, Yafeng
Format:	Artikel
Sprache:	eng
Schlagworte:	antisense RNA beta Catenin - genetics beta Catenin - metabolism bioinformatics bone formation bone marrow Bone Marrow Cells - metabolism Cell Differentiation - genetics Cells, Cultured Humans lysine Mesenchymal Stem Cells MicroRNAs - genetics Osteogenesis - genetics osteogenic differentiation Proto-Oncogene Protein c-ets-1 - metabolism proto-oncogenes Research Paper RNA, Antisense - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism transcription (genetics) transcription factors Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism USP2 USP2-AS1 Wnt Signaling Pathway Wnt/β-catenin signalling pathway
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